کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2147246 1548403 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bleomycin-induced double-strand breaks in mitochondrial DNA of Drosophila cells are repaired
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Bleomycin-induced double-strand breaks in mitochondrial DNA of Drosophila cells are repaired
چکیده انگلیسی

Mitochondrial DNA lesions cause numerous human diseases, and it is therefore important to identify the mechanisms whereby the mitochondrion repairs the damage. We have studied in cultured Drosophila cells the repair of bleomycin-induced double-strand breaks (DSBs) in mitochondrial DNA. Our results show that DSBs are repaired as rapidly and effectively in the mitochondria as in the nucleus. DNA repair is complete within 2 h following bleomycin treatment, showing that Drosophila mitochondria have an effective system of DSB repair. The mechanism and mitochondrial proteins involved remain to be identified.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 637, Issues 1–2, 1 January 2008, Pages 111–117
نویسندگان
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