Keywords: شکست دو ردیف; Anticancer activity; Apoptosis; DNA repair; Glioblastoma; Seaweed compounds; Temozolomide; AIC; 5-aminoimidazole-4-carboxamide; Akt; Protein kinase B (PKB); AP site; apurinic/apyrimidinic site; AP-1; activator protein-1; APE-1; AP endonuclease; Bax; Bcl-2
مقالات ISI شکست دو ردیف (ترجمه نشده)
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Keywords: شکست دو ردیف; Breast cancer; Normal-tissue reaction; Individual radiosensitivity; Double-strand breaks; 53BP1; p53;
Keywords: شکست دو ردیف; HPCs; hepatic progenitor cells; mtROS; mitochondrial reactive oxygen species; DEN; diethylnitrosamine; SPCs; stem/progenitor cells; HSCs; hematopoietic stem cells; NSCs; neural stem cells; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum;
Keywords: شکست دو ردیف; DSB; double-strand breaks; HR; homologous recombination; ssDNA; single-stranded DNA; NAHR; non-allelic homologous recombination; SSA; single-strand annealing; VDE; VMA1-derived homing endonuclease; NHEJ; nonhomologous end joining; MMEJ; microhomology-medi
Keywords: شکست دو ردیف; AAV; Adeno-associated virus; ARHL; age-related hearing loss; Cas9; CRISPR-associated nuclease 9; CRISPR; clustered, regularly interspaced, short palindromic repeat; crRNA; CRISPR RNA; dCas9; defective Cas9; DSBs; double-strand breaks; gRNA; guide RNA; HDR
Keywords: شکست دو ردیف; antibiotics; E. coli, metabolomics; oxidative stress; reactive oxygen species; lipid peroxidation; protein carbonylation DNA damage; double-strand breaks
Keywords: شکست دو ردیف; Helicobacter pylori; Reactive oxidative species; Double-strand breaks; Genetic recombination; Genome rearrangement; Antigenic variation
Keywords: شکست دو ردیف; ABR; Auditory Brainstem Response; DNA; deoxyribonucleic acid; DSB; double-strand breaks; Gy; Gray; kHz; kilohertz; mtDNA; mitochondrial DNA; MV; megavolt; RISNHL; radiation-induced sensorineural hearing loss; RNS; reactive nitrogen species; ROS; reactive
Keywords: شکست دو ردیف; microhomology; double-strand breaks; structural variation; genomic disorders; microhomology-mediated end joining; microhomology-mediated break-induced replication;
Keywords: شکست دو ردیف; AA; L-ascorbic acid; BSO; buthionine sulfoximine; carboxy-H2DCFDA; 6-carboxy-2â²,7â²-dichlorodihydrofluorescein diacetate; DCF; dichlorofluorescein; DEM; diethyl maleate; DSB; double-strand breaks; DTNB; dithiobis-2-nitrobenzoic acid; MTT; 3-(4,5-dimeth
Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination
Keywords: شکست دو ردیف; DSB; double-strand breaks; HR; homologous recombination; NHEJ; non-homologous end-joining; PARP; poly(ADP-ribose) polymerase; PAR; poly(ADP-ribose); MTT; methyl thiazolyl; PI; propidium iodide; SD; standard deviations; SSB; single strand break; γH2AX; ph
Impact of DNA polymerase ζ mutations on genotoxic thresholds of oxidative mutagens
Keywords: شکست دو ردیف; TLS; translesion DNA synthesis; Pol; DNA polymerase; KBrO3; potassium bromate; Na2Cr2O7; sodium dichromate; 8-oxo-dG; 7,8-dihydro-8-oxo-2â²-deoxyguanosine; D2781N; a human cell line that expresses a variant form of Pol ζ having asparagine instead of asp
Genotoxicity analysis of five particle matter toxicants from cigarette smoke based on γH2AX assay combined with Hill/Two-component model
Keywords: شکست دو ردیف; DSB; double-strand breaks; ELISA; enzyme-linked immunosorbent assay; WB; western blot; FC; flow cytometry; HCS; high content screening; PAHs; polyaromatic hydrocarbons; WHO FCTC; World Health Organization Framework Convention on Tobacco Control; CCK8; cel
DNA damage, metabolism and aging in pro-inflammatory T cells
Keywords: شکست دو ردیف; EC; endothelial cell; ROS; reactive oxygen species; ATP; adenosine 5â²-triphosphate; ER; endoplasmic reticulum; mtDNA; mitochondrial DNA; ETC; electron transport chain; mROS; mitochondrial ROS; NADPH; nicotinamide adenine dinucleotide phosphate; TNF-α;
Targeting Long Noncoding RNA HMMR-AS1 Suppresses and Radiosensitizes Glioblastoma
Keywords: شکست دو ردیف; GBM; glioblastoma; HMMR; hyaluronan-mediated motility receptor; lncRNA; long noncoding RNA; HMMR-AS1; HMMR antisense RNA 1; DSBs; double-strand breaks; ATM; ataxia telangiectasia mutated kinase; HR; homologous repair;
Telomeric Recombination Induced by DNA Damage Results in Telomere Extension and Length Heterogeneity
Keywords: شکست دو ردیف; ALT; Alternative lengthening of telomeres; APBs; ALT-associated PML bodies; BIR; Break-induced replication; CO-FISH; Chromosome orientation fluorescence in situ hybridization; DDR; DNA damage response; DOX; Doxycycline; DSBs; Double-strand breaks; HR; Hom
γH2AX is increased in peripheral blood lymphocytes of Alzheimer's disease patients in the South Australian Neurodegeneration, Nutrition and DNA Damage (SAND) study of aging
Keywords: شکست دو ردیف; Double-strand breaks; DNA damage; Mild cognitive impairment;
Double-strand breaks in genome-sized DNA caused by mechanical stress under mixing: Quantitative evaluation through single-molecule observation
Keywords: شکست دو ردیف; Double-strand breaks; Mixing procedure; Genome-sized DNA; Mechanical agitation; Single-molecule observation;
Integrating plant and animal biology for the search of novel DNA damage biomarkers
Keywords: شکست دو ردیف; ARP; actin related protein; ASK; Arabidopsis SPK1-like; At; Arabidopsis thaliana; ATAF; arabidopsis transcription activation factor; ATM; ataxia telangiectasia mutated; ATR; ATM and Rad3-related; ATRIP; ATR-interacting protein; BARD; BRCA1-associated RING
DNA damage and repair proteins in cellular response to sulfur mustard in Iranian veterans more than two decades after exposure
Keywords: شکست دو ردیف; CHK1; checkpoint kinase 1 human protein; CHK2; checkpoint kinase 2 human protein; COPD; chronic obstructive pulmonary disease; DSB; double-strand breaks; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSH; glutathione; γH2AX; phosphorylated H2AX; MRN;
Two Weeks of Variable Stress Increases Gamma-H2AX Levels in the Mouse Bed Nucleus of the Stria Terminalis
Keywords: شکست دو ردیف; BNST; bed nucleus of the stria terminalis; DSBs; double-strand breaks; GSK3β; glycogen synthase kinase 3 β; MAPK; mitogen-activated protein kinase; mPFC; medial prefrontal cortex; PBS; phosphate-buffered saline; γH2AX; Histone H2A-X phosphorylated at s
Identification of rare heterozygous missense mutations in FANCA in esophageal atresia patients using next-generation sequencing
Keywords: شکست دو ردیف; EA; esophageal atresia; TEF; tracheoesophageal fistula; FANCA; Fanconi anemia complementation group A; AEG syndrome; anophthalmia-esophageal-genital syndrome; VACTERL syndrome; vertebral, anal, cardiac, tracheo-esophageal, renal, limb syndrome; CADD score
Uncharacterized ORF HUR1 influences the efficiency of non-homologous end-joining repair in Saccharomyces cerevisiae
Keywords: شکست دو ردیف; DDA; DNA damage array; DSBs; DNA double stranded breaks; GI; genetic interaction; HR; homologous recombination; HU; hydroxyurea; MMEJ; micro-homology mediated end joining; NHEJ; non-homologous end joining; PPI; protein-protein interaction; c-NHEJ; classic
Inhibition of Rad51 sensitizes breast cancer cells with wild-type PTEN to olaparib
Keywords: شکست دو ردیف; PTEN; Phosphatase and tensin homologue; PARP; poly(ADP-ribose) polymerase; PI3K; PI3 kinase; RPA1; replication protein A1; DSB; double-strand breaks; HR; homologous recombination; SSB; single strand breaks; γH2AX; Phospho-histone H2AX; PMSF; phenylmethyl
Induction of the chromosomal translocation t(14;18) by targeting the BCL-2 locus with specific binding I-125-labeled triplex-forming oligonucleotides
Keywords: شکست دو ردیف; DSB; double-strand breaks; DTT; dithiothreitol; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid; FBS; fetal bovine serum; FISH; fluorescence in situ hybridization; mbr; major breakage re
Differences in the recruitment of DNA repair proteins at subtelomeric and interstitial I-SceI endonuclease-induced DNA double-strand breaks
Keywords: شکست دو ردیف; DNA repair; Double-strand breaks; Telomere;
Human NEIL1 DNA glycosylase: Structure, function and polymorphisms
Keywords: شکست دو ردیف; 8-oxoG; 8-dihydro-2â²-deoxyguanosine; 5-OHU; 5-hydroxyuracil; AP; apurinic/apyrimidinic; BER; base excision repair; CCA; cholangiocarcinoma; DHU; 5,6 dihydrouracil; DSB; double-strand breaks; dRP; deoxyribose phosphate; Fapy-A; 4,6-diamino-5-formamidopyr
EJC Biennial ReportGenomic signatures as predictive biomarkers of homologous recombination deficiency in ovarian cancer
Keywords: شکست دو ردیف; Ovarian cancer; Double-strand breaks; DNA repair; Homologous recombination; Alternative end joining; Non-homologous end joining; PARP inhibitor; Whole-genome sequencing; Mutational signatures; Rearrangement signatures;
Lemna minor plants chronically exposed to ionising radiation: RNA-seq analysis indicates a dose rate dependent shift from acclimation to survival strategies
Keywords: شکست دو ردیف; GO; gene ontology; IR; ionising radiation; ROS; reactive oxygen species; Sr; strontium; UV-B; ultraviolet-B; DSB; double-strand breaks; SSB; single-strand breaks; RGR; relative growth rate; β; beta; γ; gamma; Duckweed; Ionising radiation; Radiation effe
Functional relevance of miRNAs in premature ageing
Keywords: شکست دو ردیف; CRP; C-reactive protein; DDR; DNA damage response; DSB; double-strand breaks; HATs; histone acetyltransferases; HDACs; histone deacetylases; hMSCs; human mesenchymal stem cells; HRR; homologous recombination repair; MEFs; mouse embryonic fibroblast; ROS;
Experimental evidence of oxidative stress in patients with l-2-hydroxyglutaric aciduria and that l-carnitine attenuates in vitro DNA damage caused by d-2-hydroxyglutaric and l-2-hydroxyglutaric acids
Keywords: شکست دو ردیف; L-2-HGA; l-2-hydroxyglutaric aciduria; L-2-HG; l-2-hydroxyglutaric acid; D-2-HGA; d-2-hydroxyglutaric aciduria; D-2-HG; d-2-hydroxyglutaric acid; 2-HG; 2-hydroxyglutaric acid; LC; l-carnitine; L2HGDH; l-2-hydroxyglutarate dehydrogenase gene; D2HGDH; d-2-h
Valproic acid sensitizes breast cancer cells to hydroxyurea through inhibiting RPA2 hyperphosphorylation-mediated DNA repair pathway
Keywords: شکست دو ردیف; VPA; valproic acid; HU; hydroxyurea; IR; ionizing radiation; DSBs; double-strand breaks; HR; homologous recombination; RPA; replication protein A; RPA2-p; hyperphosphorylation of RPA2; wtRPA2; wild-type RPA2; muRPA2; hyperphosphorylation mutant RPA2; HDAC
Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts
Keywords: شکست دو ردیف; Pancreatic cancer; Mitotic arrest; DNA damage; Apoptosis; c-Jun N-terminal kinase; Trichodermin; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra long; CDK; cyclin-dependent kinase; Cdc; cell division cycle; DSBs; double-strand breaks; DUSP1; dual
Common and unique genetic interactions of the poly(ADP-ribose) polymerases PARP1 and PARP2 with DNA double-strand break repair pathways
Keywords: شکست دو ردیف; PARP1; PARP2; H2AX; DNA-PKcs; Ku80; Double-strand breaks;
Deletion of NAD(P)H:quinone oxidoreductase 1 represses Mre11-Rad50-Nbs1 complex protein expression in cisplatin-induced nephrotoxicity
Keywords: شکست دو ردیف; AKI; acute kidney injury; ATM; ataxia telangiectasia mutated; DSBs; double-strand breaks; MRN; Mre11, Rad50, and Nbs1; NQO1; NAD(P)H:quinone oxidoreductase 1; NAD; nicotinamide adenine dinucleotide; NQO1; NAD(P)H:quinone oxidoreductase 1; PARP1; poly[ADP-
Nuclear PTEN interferes with binding of Ku70 at double-strand breaks through post-translational poly(ADP-ribosyl)ation
Keywords: شکست دو ردیف; PTEN; Double-strand breaks; Non-homologous end-joining; Homologous recombination; Ku70; Poly(ADP-ribosyl)ation;
Human circulating ribosomal DNA content significantly increases while circulating satellite III (1q12) content decreases under chronic occupational exposure to low-dose gamma- neutron and tritium beta-radiation
Keywords: شکست دو ردیف; RFNC-VNIIEF; Russian Federal Nuclear Center - All-Russian Research Institute of Experimental Physics; IR; ionizing radiation; cfDNA; cell-free DNA; cfrDNA; cell-free rDNA; DSB; double-strand breaks; gDNA; genomic DNA; PBS; phosphate buffer saline; bp; b
Advances in therapeutic CRISPR/Cas9 genome editing
Keywords: شکست دو ردیف; Cas9; CRISPR-associated protein 9; cccDNA; covalently closed circular DNA; CCR5; chemokine receptor 5; CFTR; cystic fibrosis transmembrane conductance regulator; CRISPRs; clustered regularly interspaced short palindromic repeats; crRNA; CRISPR RNA; Crygc;
The Caenorhabditis elegans Werner syndrome protein participates in DNA damage checkpoint and DNA repair in response to CPT-induced double-strand breaks
Keywords: شکست دو ردیف; CPT; camptothecin; DSB; double-strand breaks; HU; hydroxyurea; IR; ionizing irradiation; C. elegans; DNA damage response; DNA damage checkpoint; Werner syndrome protein;
Meiotic recombination and the crossover assurance checkpoint in Caenorhabditis elegans
Keywords: شکست دو ردیف; Meiosis; Recombination; Double-strand breaks; Chromatin; Cell cycle; Feedback control; Chromosome structure;
Current status of potential applications of repurposed Cas9 for structural and functional genomics of plants
Keywords: شکست دو ردیف; CRISPR; Crop improvement; dCas9; Epigenetics; Gene editing; Gene regulation; CRISPRa; CRISPR activation; CRISPR-Cas; Clustered Regularly Interspaced Short Palindromic Repeats - CRISPR associated proteins; CRISPRi; CRISPR interference; crRNA; CRISPR RNA; D
TDP-43/FUS in motor neuron disease: Complexity and challenges
Keywords: شکست دو ردیف; AD; Alzheimer's disease; Ago2; Argonaute 2; ALS; Amyotrophic lateral sclerosis; ALS/PD; amyotrophic lateral sclerosis and Parkinsonism-dementia complex; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATF3; activating transcription factor 3
Mapping of genomic double-strand breaks by ligation of biotinylated oligonucleotides to forum domains: Analysis of the data obtained for human rDNA units
Keywords: شکست دو ردیف; Forum domains; Double-strand breaks; Fragile sites; rDNA; Bioinformatics; HEK293T
Genome-wide mapping of hot spots of DNA double-strand breaks in human cells as a tool for epigenetic studies and cancer genomics
Keywords: شکست دو ردیف; Double-strand breaks; Fragile sites; H3K4me3 marks; Bioinformatics; HEK293T
Biochemical mechanism of DSB end resection and its regulation
Keywords: شکست دو ردیف; DSB, double-strand break; HR, homologous recombination; NHEJ, nonhomologous end joining; MMEJ, microhomolgy-mediated end joining; MRN, MRE11–RAD50–NBS1 complex; RPA, replication protein AResection; Recombination; Double-strand breaks; Nucleases; Helicases
BLM protein mitigates formaldehyde-induced genomic instability
Keywords: شکست دو ردیف; 53BP1; p53 binding protein; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related; CGRP; calcitonin gene-related peptide; BLM; bloom protein; CHO; Chinese Hamster Ovary; DSB; double-strand break; DPC; DNA-protein crosslink; ATM;
Alleles of newly identified barley gene HvPARP3 exhibit changes in efficiency of DNA repair
Keywords: شکست دو ردیف; Barley; DNA repair; Double-strand breaks; PARP3; Mutagenesis; Telomere; TILLING
Human circulating plasma DNA significantly decreases while lymphocyte DNA damage increases under chronic occupational exposure to low-dose gamma-neutron and tritium β-radiation
Keywords: شکست دو ردیف; AbDNA; antibodies to DNA; IR; ionizing radiation; cfDNA; cell free DNA; ecDNA; extra-cellular DNA; DDR; DNA damage response; DSB; double-strand breaks; LMA; low-melting-point agarose; NMA; normal-melting-point agarose; NPP; nuclear power plant; PBS; phosp
The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining
Keywords: شکست دو ردیف; CTR, C-terminal region; DAPI, 4′,6-diamidino-2-phenylindole; DSBs, double-strand breaks; NHEJ, non-homologous end-joining; PBS, phosphate buffered saline; UTR, untranslated regionDNA repair; Nej1p; Lif1p; Non-homologous end-joining; Double-strand breaks
Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunction
Keywords: شکست دو ردیف; ROS; reactive oxygen species; H2O2; hydrogen peroxide; NAC; N-acetylcysteine; MN; micronuclei; DSBs; double-strand breaks; MSF; primary mouse skin fibroblasts; Micronuclei; Genomic instability; p53; Oxidative stress; Replication stress;