Methodological considerations for mutagen exposure in C. elegans
Keywords: شکست دو ردیف; DNA damage repair; Mutagen; Double-strand breaks
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The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability
Keywords: شکست دو ردیف; R-loops; Genome instability; Double-strand breaks; G-quadruplex; Topoisomerase; THO/TREX complex; THSC/TREX-2; ASF splicing factor; mRNP biogenesis; RNA processing factors; RNase H; RNA:DNA helicases; Senataxin; Activation-induced deaminase (AID); APOBEC
Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells
Keywords: شکست دو ردیف; CRC; colorectal cancer; CPT; camptothecin; DSBs; double-strand breaks; DDR; DNA damage response; γ-H2AX; phosphorylated histone H2AX; ATM; ataxia telangiectasia mutated; Chk2; check-point kinase; AMPK; AMP-activated protein kinase; TSC2; tuberous scleros
A highly efficient site-specific integration strategy using combination of homologous recombination and the ΦC31 integrase
Keywords: شکست دو ردیف; Site-specific integration; ΦC31 integrase; Double-strand breaks; Homologous recombination; Pseudo-attP site;
Ionizing radiation-induced gene expression changes in TP53 proficient and deficient glioblastoma cell lines
Keywords: شکست دو ردیف; GBM; glioblastoma; MT; mutated; WT; wild type; SAM; significance analysis of microarray; FDR; false discovery rate; qPCR; quantitative real-time PCR; SSBs; single-strand breaks; DSBs; double-strand breaks; HRR; homologous recombination repair; NHEJ; non-h
Nanoneedle insertion into the cell nucleus does not induce double-strand breaks in chromosomal DNA
Keywords: شکست دو ردیف; Nanoneedle; Atomic force microscope; Cell nucleus; γ-H2AX; UV-irradiation; Double-strand breaks
The catalytic subunit of DNA-dependent protein kinase is downstream of ATM and feeds forward oxidative stress in the selenium-induced senescence response
Keywords: شکست دو ردیف; ATM; ataxia-telangiectasia mutated; CM-H2DCFDA; 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate, acetyl ester; DAPI; 4,6-diamidino-2-phenylindole; DNA-PKcs; the catalytic subunit of DNA-dependent protein kinase; DSBs; double-strand bre
Alteration of the DNA damage response in colorectal tumor progression
Keywords: شکست دو ردیف; DSB(s), DNA double-strand break(s); DDR, DNA damage response; 53BP1, p53-binding protein 1; LI, labeling indexColorectal carcinoma; Double-strand breaks; DNA damage response; γH2AX; p53-binding protein 1
Enigmatic roles of Mcm10 in DNA replication
Keywords: شکست دو ردیف; Mcm10; DNA replication; double-strand breaks; genome integrity; replication forks; OB-fold; Zn-finger domains
Trapping and breaking of in vivo nicked DNA during pulsed field gel electrophoresis
Keywords: شکست دو ردیف; Field strength; Time of electrophoresis; DNA trapping; Single-strand breaks; Double-strand breaks
The spatial regulation of meiotic recombination hotspots: Are all DSB hotspots crossover hotspots?
Keywords: شکست دو ردیف; Meiosis; Hotspots; Homologous recombination; Double-strand breaks; Chromosome features
O-GlcNAc modification affects the ATM-mediated DNA damage response
Keywords: شکست دو ردیف; ATM; ataxia telangiectasia mutated; O-GlcNAc; O-linked β-N-acetylglucosamine; DSBs; double-strand breaks; SMC1; structural maintenance of chromosomes 1; OGT; O-linked β-N-acetylglucosamine transferase; OGA; O-linked β-N-acetylglucosaminidase; PP2A; pro
AIDing antibody diversity by error-prone mismatch repair
Keywords: شکست دو ردیف; Mismatch repair; Class switch recombination; Somatic hypermutation; Activation-induced deaminase; Double-strand breaks; Cytosine deamination; Epigenetic; Antibody diversity
Telomere dysfunction and chromosome instability
Keywords: شکست دو ردیف; A-NHEJ; alternative nonhomologous end joining; B/F/B; breakage/fusion/bridge; C-NHEJ; classical nonhomologous end joining; DSBs; double-strand breaks; GCRs; gross chromosome rearrangements; HSV-tk; herpes simplex thymidine kinase; NHEJ; nonhomologous end
Anaphase DNA bridges induced by lack of RecQ5 in Drosophila syncytial embryos
Keywords: شکست دو ردیف; DSBs; double-strand breaks; Mnk; maternal nuclear kinase; PH3; phosphorylated histone H3; His2Av-mRFP1; monomeric red fluorescent protein 1-tagged histone 2AvD; DAPI; 4â²,6-diamidino-2-phenylindole; PI; propidium iodide; RecQ; DNA repair; Double-strand b
Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4â²-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents
Keywords: شکست دو ردیف; Anticancer drugs; Cancer therapeutics; Cytotoxicity; Double-strand breaks; Apoptosis; Cell death;
Diepoxybutane induces the formation of DNA-DNA rather than DNA-protein cross-links, and single-strand breaks and alkali-labile sites in human hepatocyte L02 cells
Keywords: شکست دو ردیف; AGT; O6-alkylguanine DNA-alkyl transferase; ALS; alkali-labile sites; BD; 1,3-butadiene; BDD; 3-butene-1,2-diol; DEB; 1,2,3,4-diepoxybutane; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; DPC; DNA-protein cross-links; DSB; double-st
Novel rhodanine derivatives induce growth inhibition followed by apoptosis
Keywords: شکست دو ردیف; Chemotherapy; Double-strand breaks; Cytotoxicity; DNA damage; 5-Benzilidene-3-ethyl rhodanine
Resveratrol induces DNA double-strand breaks through human topoisomerase II interaction
Keywords: شکست دو ردیف; RSV, resveratrol; TOPO II, topoisomerase II; DSBs, double-strand breaksγH2AX; Cell cycle; Topoisomerase II; Double-strand breaks; Cytofluorimetric assay
HMGNs, DNA repair and cancer
Keywords: شکست دو ردیف; HMGN proteins; Nucleotide excision repair; Transcription coupled repair; Double-strand breaks; DNA damage response; Histone H1
Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break
Keywords: شکست دو ردیف; Activation-induced deaminase; AID; Base excision repair; Somatic hypermutation; Double-strand breaks; Mutagenesis
Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks
Keywords: شکست دو ردیف; PARP-1; PARP inhibitor; Methyl methanesulfonate; Cell cycle; Double-strand breaks; γ-H2A.X
Variant base excision repair proteins: Contributors to genomic instability
Keywords: شکست دو ردیف; BER; base excision repair; ROS; reactive oxygen species; SAM; S-adenosylmethionine; APE1; apurimidinic endonuclease I; MTH; MutT homolog; OGG1; DNA glycosylase 8-oxoguanine glycosylase; FapyG; 2,6-diamino-4-hydroxy-5-formamidopyrimidine; 5-meC; 5-methylcy
Animal models of mitochondrial DNA transactions in disease and ageing
Keywords: شکست دو ردیف; mtDNA replication; mtDNA repair and recombination; Mitochondrial transcription; Animal models; Mouse; Drosophila; mtDNA; mitochondrial DNA; OXPHOS; oxidative phosphorylation system; ROS; reactive oxygen species; COX; cytochrome c oxidase; PD; Parkinson'
TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations
Keywords: شکست دو ردیف; TREX2; Exonuclease; Double-strand breaks; Robertsonian translocations; Genomic stability
Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence
Keywords: شکست دو ردیف; Ionizing radiation; DNA repair; Non-homologous end joining (NHEJ); Homologous recombination; Double-Strand Breaks; DNA-PK; DNA ligase III; Histone H1; PARP-1
The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair
Keywords: شکست دو ردیف; Squamous cell carcinoma; Tumour radiosensitivity; Double-strand breaks; Repair; Prediction
Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage
Keywords: شکست دو ردیف; Berberine; p53; Genotoxicity; Cell cycle arrest; Apoptosis; Double-strand breaks
DNA breakage associated with targeted gene alteration directed by DNA oligonucleotides
Keywords: شکست دو ردیف; Single-stranded oligonucleotides; Targeted gene alteration; Double-strand breaks
DNA double-strand breaks in meiosis: Checking their formation, processing and repair
Keywords: شکست دو ردیف; Double-strand breaks; Meiosis; Checkpoint; CDK; Mek1; Rad53
DNA-repair-deficient Rad54/Rad54B mice are more sensitive to clastogens than wild-type mice
Keywords: شکست دو ردیف; DNA-repair; Double-strand breaks; Clastogens; LacZ mutant frequencies; Chromosomal rearrangements
Ku, Artemis, and ataxia-telangiectasia-mutated: Signalling networks in DNA damage
Keywords: شکست دو ردیف; AT; ataxia-telangiectasia; ATM; ataxia-telangiectasia-mutated; ATR; ataxia-telangiectasia and Rad3-related; DNA-PK; DNA-dependent protein kinase; DNA-PKcs; catalytic subunit of DNA-dependent protein kinase; DSBs; double-strand breaks; ROS; reactive oxygen
Bleomycin-induced double-strand breaks in mitochondrial DNA of Drosophila cells are repaired
Keywords: شکست دو ردیف; Bleomycin; Drosophila; Mitochondrial DNA repair; Double-strand breaks
DNA damage in peripheral blood lymphocytes in patients during combined chemotherapy for breast cancer
Keywords: شکست دو ردیف; SSB; DNA single-strand breaks; DSB; double-strand breaks; PBLs; peripheral blood lymphocytes; AP; apurinic sites; ROS; reactive oxygen species; TM; tail moment; FAP; 5-fluorouracil, adriamycin and cisplatin; FEC; 5-fluorouracil, epirubicin and cyclophosph
DNA mismatch repair-induced double-strand breaks
Keywords: شکست دو ردیف; DNA mismatch repair; Double-strand breaks; Recombination; Cisplatin; MNNG
DNA double-strand breaks: A potential causative factor for mammalian aging?
Keywords: شکست دو ردیف; Double-strand breaks; Nonhomologous end joining; DNA damage response; Cellullar senescence; Apoptosis
Organization and evolution of mitochondrial gene clusters in human
Keywords: شکست دو ردیف; NEMP; nuclear-encoded mitochondrial protein; ppNEMP; processed pseudogene of NEMP; mtDNA; mitochondrial DNA; NHEJ; nonhomologous end-joining; DSB; double-strand breaks; Endosymbiosis; Evolutionary pocket; Gene cluster; Nuclear-encoded mitochondrial protei
Mouse models of DNA double-strand break repair and neurological disease
Keywords: شکست دو ردیف; DNA repair; Double-strand breaks; Homologous recombination; Non-homologous end-joining; Neurodegeneration; Nervous system
RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites
Keywords: شکست دو ردیف; Double-strand breaks; RAP80; RNF8; Ubiquitination; CCDC98/Abraxas; BRCA1; UIM; MDC1
Interplay of two major repair pathways in the processing of complex double-strand DNA breaks
Keywords: شکست دو ردیف; Clustered DNA damage; Base excision repair; Double-strand breaks; Ligation; Oxidised guanine
RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae
Keywords: شکست دو ردیف; Homologous recombination; Double-strand breaks; Single-strand annealing; Translocation; Repetitive sequences
Surveillance mechanisms monitoring chromosome breaks during mitosis and meiosis
Keywords: شکست دو ردیف; Checkpoint; Double-strand breaks; Mitosis; Meiosis; Rad53; Mek1
DNA triple helices: Biological consequences and therapeutic potential
Keywords: شکست دو ردیف; Triplex DNA; DNA triple helices; Triplex-forming oligonucleotides; H-DNA; Unusual DNA structures; Genetic instability; 2â²-OMe; 2â²-O-methylribose; 2â²-AE; 2â²-O-aminoethylribose; ADPKD; autosomal dominant polycystic kidney disease; BePI; benzo[e]pyri
Transforming growth factor beta-1 enhances cytotoxic effect of doxorubicin in human lung adenocarcinoma cells of A549 line
Keywords: شکست دو ردیف; Doxorubicin; TGFbeta-1; Apoptosis; Human lung adenocarcinoma A549 cells; DSB; double-strand breaks; PARP; poly(ADP-ribose)polymerase; TGFbeta-1; transforming growth factor beta-1;
Activation of Telomerase by Ionizing Radiation: Differential Response to the Inhibition of DNA Double-Strand Break Repair by Abrogation of Poly(ADP-ribosyl)ation, by LY294002, or by Wortmannin
Keywords: شکست دو ردیف; Telomerase; Irradiation; Double-strand breaks; LY294002; Wortmannin;
The DNA damage response during an unperturbed S-phase
Keywords: شکست دو ردیف; A-T; Ataxia-Telangiectasia; ATM; Ataxia-Telangiectasia Mutated; ATR; ATM and Rad3 related (mec1); DSBs; double-strand breaks; ssDNA; single strand DNA; PIKK; phosphoinositol kinase like kinase; IR; ionizing radiation; UV; ultraviolet; HU; hydroxyure
Dual activity of nitroxides as pro- and antioxidants: Catalysis of copper-mediated DNA breakage and H2O2 dismutation
Keywords: شکست دو ردیف; OP; o-phenanthroline; RNO; nitroxide; RNO-H; hydroxylamine; RN+O; oxoammonium cation; 3-CP; 3-carbamoylproxyl; TPO; 2,2,6,6-tetramethylpiperidine-N-oxyl; PB; phosphate buffer; ssb; single-strand breaks; dsb; double-strand breaks; Copper; o-Phenanthroline;
Activation-induced cytidine deaminase acts on double-strand breaks in vitro
Keywords: شکست دو ردیف; Somatic hypermutation; Activation-induced cytidine deaminase; Double-strand breaks
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain
Keywords: شکست دو ردیف; Double-strand breaks; Ataxia telangiectasia; Cerebellum; TDP1; Bergmann glia; Golgi neuron;
The novel gene mus7+ is involved in the repair of replication-associated DNA damage in fission yeast
Keywords: شکست دو ردیف; Mus7; DNA repair; Replication-associated DNA damage; Double-strand breaks; Homologous recombination; MMS;