کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7803087 | 1501176 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4â²-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
⺠Levamisole, derivatives has been reported as potential antitumor agent in patients with small tumor burdens. We synthesized and evaluated biological activity of novel analogues of levamisole on leukemia cells. ⺠The cytotoxicity was studied using trypan blue and MTT assays and found that 3a, 4a, and 4c exhibited strong cytotoxicity. ⺠Among these we chose 4a (IC50, 8 μM) for understanding the mechanism of cytotoxicity. ⺠FACS analysis in conjunction with mitochondrial membrane potential and DNA fragmentation studies suggested that 4a induced apoptosis, but not cell cycle arrest.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 6, June 2011, Pages 2109-2116
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 6, June 2011, Pages 2109-2116
نویسندگان
Subhas S. Karki, Kuppusamy Panjamurthy, Sujeet Kumar, Mridula Nambiar, Sureshbabu A. Ramareddy, Kishore K. Chiruvella, Sathees C. Raghavan,