کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1980985 | 1061892 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The DNA damage response during an unperturbed S-phase
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کلمات کلیدی
Mitomycin CATR-interacting proteinAtaxia–TelangiectasiaFANCMre11-Rad50-Nbs1APHmDC1FHAMCMssDNAMRNDSBsBLMCDKORCATRRDSMMCSingle strand DNA - DNA تک رشته ایSingle-stranded DNA - DNA تک رشته ایPIKK - LIKKUltraviolet - اشعه فرابنفشionizing radiation - تابش یوننده یا پرتوهای یونیزانATM - خودپردازATRIP - سفرdouble-strand breaks - شکست دو ردیفBloom - شکوفهCheckpoints - نقاط بازرسیReplication - همانندسازی Hydroxyurea - هیدروکسی اورهChk - چاکcyclin-dependent kinase - کییناز وابسته به سیکلین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
DNA replication is a highly conserved and controlled process. To maintain genome integrity, the DNA must be faithfully duplicated once before chromosomes are segregated to daughter cells. Experimental insults to cells during DNA replication trigger an array of responses to help cells cope with DNA damage and replication stress. This has been coined the DNA damage response. During an unperturbed S-phase, DNA lesions and aberrant DNA structures arise as a consequence of normal DNA replication. Recent data suggest that the same pathways regulating the response to acute DNA damage also operate during normal S-phase to maintain genome integrity in the face of low levels of damage. This review will focus on the role of key proteins and signaling pathways, originally identified by their requirement to maintain genome stability during DNA replication following experimental insults, in the regulation of progression through normal S-phase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 6, Issue 7, 1 July 2007, Pages 914-922
Journal: DNA Repair - Volume 6, Issue 7, 1 July 2007, Pages 914-922
نویسندگان
Merav Ben-Yehoyada, Jean Gautier, Aude Dupré,