Keywords: GO; Gene Ontology; EXP; Inferred from Experiment; IDA; Inferred from Direct Assay; IPI; Inferred from Physical Interaction; IMP; Inferred from Mutant Phenotype; IGI; Inferred from Genetic Interaction; IEP; Inferred from Expression Pattern; DEGs; different
مقالات ISI (ترجمه نشده)
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Keywords: ALDH; aldehyde dehydrogenase; CSCs; cancer stem cells; Cis; cisplatin; DEAB; N,N-diethylaminobenzaldehyde; DCFAB; 2â²,7â²-dichlorofluorescin diacetate; Dox; doxorubicin; DSBs; DNA double strand breaks; DLL4; delta-like 4; EGF; epidermal growth factor; E
Keywords: Cancer; Phytochemical; Radiotherapy; Radioprotection; Side effects; AP-1; activator protein-1; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; CAPE; caffeic acid phenylethylester; CAT; chloramphenicol acetyltransferase; CBMN; cytokinesis block
Keywords: Arsenic; Inorganic arsenic; Carcinogenesis; Epidemiology; Methylation; Signal transduction; As3MT; arsenic-3-methyl transferase enzyme; BER; base excision repair; CA; chromosomal aberration; DAPK; death-associated protein kinase; DMA; dimethylarsinous aci
Keywords: Phytol nanoemulsion; Toxicogenetic effect; Adaptive response; ATM; ataxia telangiectasia-mutated; ATR; ataxia telangiectasia-mutated-Rad3-related kinase; Casp; caspase; CYP-c; cytochrome-c; DSBs; double strand breaks; EOs; essential oils; ERK; extracellul
Keywords: AgNPs; silver nanoparticles; cit; citrate; PVP; polyvinylpyrrolidone; AgOAc; silver acetate; Ag+;  silver ions; 8-oxoG; 7,8-dihydro-8-oxoguanine; γ-H2AX; phosphorylated histone 2AX; DSBs; double strand breaks; MN; micronuclei; SPR; surface plasmon reson
Keywords: ATIR; anti-tumor immune response; ATM; ataxia telangiectasia mutated; CDK; cyclin-dependent kinase; CGH; comparative genomic hybridization; CHK1; checkpoint kinase 1; CHK2; checkpoint kinase 2; DDAs; DNA-damaging agents; DDR; DNA damage response; DSBs; do
Keywords: ATP; adenosine triphosphate; DSBs; double strand breaks; MMR; mismatch repair; PCGs; pairing control genes; ROS; reactive oxygen species; WGD; whole genome duplication; Gene conversion; Homoeolog; Hybrid; Meiosis; Polyploid; Recombination;
Keywords: HPCs; hepatic progenitor cells; mtROS; mitochondrial reactive oxygen species; DEN; diethylnitrosamine; SPCs; stem/progenitor cells; HSCs; hematopoietic stem cells; NSCs; neural stem cells; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum;
Keywords: DSBs; double strand breaks; SSBs; single strand breaks; HR; homologous recombination; NHEJ; non-homologous end-joining; CSA; Cockayne syndrome protein A; CSB; Cockayne syndrome protein B; TC-NER; transcription-coupled nucleotide excision repair; TC-DSBR;
Keywords: ADH; alcohol dehydrogenase; BSA; bovine serum albumin; C60HyFn; hydrated C60 fullerene; CNTs; carbon nanotubes; DF-1; dendro[C60]fullerene-1; DRF; dose reducing factor; DSBs; DNA double-strand breaks; DU145; prostatic adenocarcinoma cell line; ESR; electr
Keywords: Nitric oxide; H2O2; SNAP; Oxidative/nitrosative stress; Antioxidant; Neuron; 3-NT; 3-nitrotyrosine; ANOVA; one-way analysis of variance; CAT; catalase; CBA; Coumarin boronic acid; CNS; central nervous system; COH; hydroxycoumarin; DCFH-DA; 2â²,7'-dichlor
Keywords: AAV; Adeno-associated virus; ARHL; age-related hearing loss; Cas9; CRISPR-associated nuclease 9; CRISPR; clustered, regularly interspaced, short palindromic repeat; crRNA; CRISPR RNA; dCas9; defective Cas9; DSBs; double-strand breaks; gRNA; guide RNA; HDR
Keywords: ATM; ataxia telangiectasia-mutated kinase; ATR; ataxia telangiectasia and Rad3-related kinase; CI; combination index; CLL; chronic lymphocytic leukemic cells; DNA-PK; DNA-dependent protein kinase; DNA-PKcs; DNA-dependent protein kinase catalytic subunit;
Keywords: CNS; central nervous system; DAPI; 4,6-diamidin-2-phenylindol; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; DSBs; double strand breaks; EDTA; ethylenediaminetetraacetic acid; eNOS; endothelial NOS; ERK; extracellular-signal-regu
Keywords: Boron neutron capture therapy; High LET radiation; DSBs; γH2AX foci
Keywords: γ-H2AX; DSBs; Peripheral lymphocytes; Obesity; HMGB1
Impact of DNA polymerase ζ mutations on genotoxic thresholds of oxidative mutagens
Keywords: TLS; translesion DNA synthesis; Pol; DNA polymerase; KBrO3; potassium bromate; Na2Cr2O7; sodium dichromate; 8-oxo-dG; 7,8-dihydro-8-oxo-2â²-deoxyguanosine; D2781N; a human cell line that expresses a variant form of Pol ζ having asparagine instead of asp
Synthesis and biological evaluation of 4β-(thiazol-2-yl)amino-4â²-O-demethyl-4-deoxypodophyllotoxins as topoisomerase-II inhibitors
Keywords: Podophyllotoxin; Topo-II inhibitors; DSBs; Cell cycle arrest;
The functional roles of PML nuclear bodies in genome maintenance
Keywords: PML-NB; promyelocytic leukemia nuclear body; DSBs; DNA double-strand breaks; HR; homologous recombination; APL; acute promyelocytic leukemia; ALT; alternative lengthening of telomere; APB; ALT-associated PML bodies; PML nuclear body; SUMOylation; DNA repa
Isoorientin triggers apoptosis of hepatoblastoma by inducing DNA double-strand breaks and suppressing homologous recombination repair
Keywords: Isoorientin; ATM; MRN complex; DSBs; HR;
hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells
Keywords: ATC; anaplastic thyroid cancer; BER; base excision repair; CREB; cAMP response element binding protein; DAPI; 4â²,6-diamidine-2-phenylindole dihydrochloride; DDR; DNA damage response; dNTP; deoxynucleoside triphosphate; DSBs; double-stand breaks; DTC; di
Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA
Keywords: A-EJ; alternative end joing; APH; aphidicolin; BIR; break induced replication; BTRR; BLM helicase/topoisomerase IIIa (TOPOIIIa)/RMI1 and RMI2 cofactors; CFS; common fragile sites; Cis; cisplatin; DEB; diepoxybutane; DSBs; double strand breaks; DSEs; one e
Targeting Long Noncoding RNA HMMR-AS1 Suppresses and Radiosensitizes Glioblastoma
Keywords: GBM; glioblastoma; HMMR; hyaluronan-mediated motility receptor; lncRNA; long noncoding RNA; HMMR-AS1; HMMR antisense RNA 1; DSBs; double-strand breaks; ATM; ataxia telangiectasia mutated kinase; HR; homologous repair;
Caspase-mediated cleavage of X-ray repair cross-complementing group 4 promotes apoptosis by enhancing nuclear translocation of caspase-activated DNase
Keywords: XRCC4; X-ray repair cross-complementing group 4; STS; staurosporine; CAD; caspase-activated DNase; ICAD; inhibitor of CAD; SRSF; serine/arginine-rich splicing factor; SRPK; SR protein kinase; Bcl; B-cell lymphoma; CLK; Cdc2-like kinase; Lig4; DNA ligase I
Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation
Keywords: 2-MeOE1/E2; 4-MeOE1/E2, methoxyestrogens; 2-OHE1/E2; 4-OHE1/E2, hydroxyestrogens; 53BP1; tumor protein p53 binding protein 1; DMBA; 7,12-dimethylbenz(a)anthracene; DSBs; DNA double-strand breaks; E1; estrone; E2; estradiol; E2-3G; E2-3-glucuronide; E2-17G
Telomeric Recombination Induced by DNA Damage Results in Telomere Extension and Length Heterogeneity
Keywords: ALT; Alternative lengthening of telomeres; APBs; ALT-associated PML bodies; BIR; Break-induced replication; CO-FISH; Chromosome orientation fluorescence in situ hybridization; DDR; DNA damage response; DOX; Doxycycline; DSBs; Double-strand breaks; HR; Hom
Breast cancer susceptibility protein 1 (BRCA1) rescues neurons from cerebral ischemia/reperfusion injury through NRF2-mediated antioxidant pathway
Keywords: ARE; antioxidative response element; AD; Alzheimer disease; ALS; amyotrophic lateral sclerosis; BRCA1; breast cancer susceptibility protein 1; BRCT; BRCA1 C-terminal; BER; base excision repair; CaMKII; calcium/calmodulin-dependent protein kinase II; CNS;
A cardiac glycoside HTF-1 isolated from Helleborus thibetanus Franch displays potent in vitro anti-cancer activity via caspase-9, MAPK and PI3K-Akt-mTOR pathways
Keywords: Cardiac glycoside; Anti-Cancer; Helleborus thibetanus Franch.; Apoptosis; ERK and JNK pathways; PI3K-Akt-mTOR pathway; CGs; cardiac glycosides; FEN1; flap endonuclease 1; PARP; (poly (ADP-ribose) polymerase; MAPK; mitogen-activated protein kinase; ERK1/2;
Two Weeks of Variable Stress Increases Gamma-H2AX Levels in the Mouse Bed Nucleus of the Stria Terminalis
Keywords: BNST; bed nucleus of the stria terminalis; DSBs; double-strand breaks; GSK3β; glycogen synthase kinase 3 β; MAPK; mitogen-activated protein kinase; mPFC; medial prefrontal cortex; PBS; phosphate-buffered saline; γH2AX; Histone H2A-X phosphorylated at s
Identification of rare heterozygous missense mutations in FANCA in esophageal atresia patients using next-generation sequencing
Keywords: EA; esophageal atresia; TEF; tracheoesophageal fistula; FANCA; Fanconi anemia complementation group A; AEG syndrome; anophthalmia-esophageal-genital syndrome; VACTERL syndrome; vertebral, anal, cardiac, tracheo-esophageal, renal, limb syndrome; CADD score
Chemical characterization and cytotoxic, genotoxic, and mutagenic properties of Baccharis trinervis (Lam, Persoon) from Colombia and Brazil
Keywords: CHO; Chinese Hamster Ovary; AE; Aqueous extracts; B; Brazil; C; Colombia; EAF; Ethyl Acetate Fraction; BF; Butanol Extract; ARF; Aqueous Residue Fraction; HPLC; High Performance Liquid Chromatography; HRMS; High Resolution Mass Spectrometry; MTT; 3-(4.5-d
Uncharacterized ORF HUR1 influences the efficiency of non-homologous end-joining repair in Saccharomyces cerevisiae
Keywords: DDA; DNA damage array; DSBs; DNA double stranded breaks; GI; genetic interaction; HR; homologous recombination; HU; hydroxyurea; MMEJ; micro-homology mediated end joining; NHEJ; non-homologous end joining; PPI; protein-protein interaction; c-NHEJ; classic
Tumor-promoting cyanotoxin microcystin-LR does not induce procarcinogenic events in adult human liver stem cells
Keywords: HL1-hT1; Microcystin-LR; Adult liver stem cells; Liver tumor-promotion; OATP; Multidrug resistance proteins; AB; Alamar Blue; AFP; α-fetoprotein; ALB; albumin; BCRP; breast cancer resistance protein; BSP; bromosulfophthalein; CFDA-AM; 5-carboxyfluorescei
ROS signalling in the biology of cancer
Keywords: AEJ; alternative end joining; ALL; acute lymphoblastic leukaemia; AML; acute myeloid leukaemia; Apaf-1; apoptotic protein activating factor 1; APL; acute promyelocytic leukaemia; ASK1; apoptosis signal regulating kinase 1; Bcr-Abl; breakpoint cluster-Abel
The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance
Keywords: ABCB1; ATP-binding cassette sub-family B member 1; AML; acute myeloid leukaemia; AMPK; adenosine monophosphate-activated protein kinase; ATM; Ataxia-telangiectasia mutated; AURKA; aurora kinase A; BER; base excision repair; Bim; B-cell lymphoma 2 interact
Impact of obesity and overweight on DNA stability: Few facts and many hypotheses
Keywords: AGEs; advanced glycation end products; AP-1; activating protein -1; APE1; apurinic/apyrimidinic endonuclease 1; BER; base excision repair; BMI; body mass index; CAF; cafeteria diet; CAT; Catalase; CBMN-Cyt; cytokinesis block micronucleus cytome assay; CEL
Measurement of DNA damage in peripheral blood by the γ-H2AX assay as predictor of colorectal cancer risk
Keywords: DSBs; DNA double-strand breaks; PBLs; peripheral blood lymphocytes; CRC; colorectal cancer; IR; ionizing radiation; ORs; odds ratios; BMI; body mass index; HR; homologous recombination; NHEJ; non-homologous end joining; Gamma H2AX; Colorectal cancer risk;
Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome
Keywords: CPC; choroid plexus carcinoma; DSBs; double-strands breaks; LFS; Li-Fraumeni syndrome; mFISH; multicolour fluorescence in-situ hybridization; NHEJ; non-homologous end-joining; SEM; scanning electron microscopy; TEM; transmission electron microscopy; γH2A
DNA damage, repair monitoring and epigenetic DNA methylation changes in seedlings of Chernobyl soybeans
Keywords: CNPP; Chernobyl nuclear power plant; IR; ionizing radiation; ROS; reactive oxygen species; SSBs; single strand breaks; DSBs; double strand breaks; R-C; radio-contaminated; DMSO; dimethyl sulfoxide; N/N; neutral unwinding/neutral electrophoresis; A/N; alka
Multiple repair pathways mediate cellular tolerance to resveratrol-induced DNA damage
Keywords: HR; homologous recombination; TLS; translesion DNA synthesis; SSBR; single-strand break repair; BER; base excision repair; NER; nucleotide excision repair; NHEJ; non-homologous end joining; PPR; postreplication repair; DSBs; double- strand breaks; WT; wil
Original ArticleThe depletion of ATM inhibits colon cancer proliferation and migration via B56γ2-mediated Chk1/p53/CD44 cascades
Keywords: ATM; Colon cancer; B56γ2; CD44; Tumorigenic potential; ATM; Ataxia-telangiectasia mutated; PIKK; phosphatidylinositol-3 kinase related kinase; FAT; FRAP-ATM-TRRAP domain; FATC; FAT-C-terminal domain; DDR; DNA damage response; DSBs; double strand breaks;
Interaction of Quindoline derivative with telomeric repeat-containing RNA induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2
Keywords: ALT; alternative lengthening of telomeres; ATM; ataxia telangiectasia mutated; CD; circular dichroism; ChIP; chromatin immunoprecipitation; DAPI; 4â²,6-diamidino-2-phenylindole; DDR; DNA damage response; DMSO; dimethyl sulfoxide; DSBs; DNA double-strand
Original ArticleHDAC4 and HDAC6 sustain DNA double strand break repair and stem-like phenotype by promoting radioresistance in glioblastoma cells
Keywords: HDAC4; HDAC6; Glioblastoma; Radiotherapy; Radioresistance; GBM; glioblastoma; TMZ; temozolomide; RT; radiotherapy; HDACs; Histone deacetylases; HATs; Histone acetyltransferases; DSBs; DNA double-strand breaks; OS; Overall survival; shRNA; short hairpin RN
ReviewTranscription and DNA Damage: Holding Hands or Crossing Swords?
Keywords: DSBs; DNA double-strand breaks; DDR; DNA damage response; MRN; MRE11-RAD50-NBS1; ATM; ataxia telangiectasia mutated; MDC1; mediator of DNA-damage checkpoint; 53BP1; p53-binding protein; NHEJ; non-homologous end joining; ncRNA; non-coding RNA; HR; homo
Fragile sites, dysfunctional telomere and chromosome fusions: What is 5S rDNA role?
Keywords: 5S rDNA; 5S ribosomal DNA; 5S rRNA; 5S ribosomal RNA; a; acrocentric; DSBs; double strand breaks; FISH; fluorescence in situ hybridization; ITS; interstitial telomeric sites; LINE; long interspaced nuclear element; LTR; long terminal repeat; m; metacentri
Valproic acid sensitizes breast cancer cells to hydroxyurea through inhibiting RPA2 hyperphosphorylation-mediated DNA repair pathway
Keywords: VPA; valproic acid; HU; hydroxyurea; IR; ionizing radiation; DSBs; double-strand breaks; HR; homologous recombination; RPA; replication protein A; RPA2-p; hyperphosphorylation of RPA2; wtRPA2; wild-type RPA2; muRPA2; hyperphosphorylation mutant RPA2; HDAC
Experimental evidence of oxidative stress in patients with l-2-hydroxyglutaric aciduria and that l-carnitine attenuates in vitro DNA damage caused by d-2-hydroxyglutaric and l-2-hydroxyglutaric acids
Keywords: L-2-HGA; l-2-hydroxyglutaric aciduria; L-2-HG; l-2-hydroxyglutaric acid; D-2-HGA; d-2-hydroxyglutaric aciduria; D-2-HG; d-2-hydroxyglutaric acid; 2-HG; 2-hydroxyglutaric acid; LC; l-carnitine; L2HGDH; l-2-hydroxyglutarate dehydrogenase gene; D2HGDH; d-2-h
The roles of subcellularly located EGFR in autophagy
Keywords: AMPK; AMP-activated protein kinase; ATG; autophagy-related; BCL2; B-cell lymphoma 2; BCL2L1; BCL2 like 1; BNIP3; BCL2/Adenovirus E1B-binding protein Nip3; CME; clathrin-mediated endocytosis; cytoSTAT3; cytoplasmic STAT3; Dsbs; double strand breaks; ECD; e
Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts
Keywords: Pancreatic cancer; Mitotic arrest; DNA damage; Apoptosis; c-Jun N-terminal kinase; Trichodermin; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra long; CDK; cyclin-dependent kinase; Cdc; cell division cycle; DSBs; double-strand breaks; DUSP1; dual