دانلود مقالات ISI درباره چاک + ترجمه فارسی

تتراندرین و سرطان - یک مروری بر رویکرد مولکولی

Tetrandrine and cancer - An overview on the molecular approach

Keywords: چاک; ADAM; a disintegrin and metalloproteinase; AKT; protein kinase B; APAF 1; apoptotic protease activating factor 1; APC; adenomatous polyposis coli; ATG; autophagy protein; BAK; Bcl 2 homologous antagonist/killer; BAX; Bcl-2 associated -X protein; Bcl-2; B-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

مکانیزم های زنده ماندن سلول های یوکاریوتی: ارتباط بیماری و مداخلات درمانی

Eukaryotic cell survival mechanisms: Disease relevance and therapeutic intervention

Keywords: چاک; ATM; ataxia telangiectasia mutated; ATR; ATM-Rad3-related; AMPK; AMP-activated protein kinase; AD; Alzheimer's disease; ARE; antioxidant response element; ATF6; activating transcription factor 6; BiP; binding immunoglobulin protein; BRAC1; Breast cancer 1

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

تاثیر پیری سلولی در پیری پوست: مفهوم استراتژی های موزاییک و درمانی

The impact of cellular senescence in skin ageing: A notion of mosaic and therapeutic strategies

Keywords: چاک; 53BP1; 53-binding protein 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia mutated and Rad3-related; AURKA; aurora kinase A; CDK; cyclin-dependent kinase; Chk; checkpoint kinase; DDR; DNA damage response; DNA-SCARS; DNA segments with chro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

فلاونوئیدهای گیاهی در شیمیدرمانی سرطان: نقش در پایداری ژنوم

Plant flavonoids in cancer chemoprevention: role in genome stability

Keywords: چاک; Cancer; Flavonoids; Chemoprevention; Dietary antioxidants; DNA damage signaling and repair; Polyphenols; DNA damage detection; Genome stability; ATM; ataxia telangiectasia mutated; ATR; ATM-Rad3-related; BRCA; breast cancer proteins; CHK; checkpoint kinas

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

پایداری ژنوم محصولات برنامه ریزی شده سلول های بنیادی

Genome stability of programmed stem cell products

Keywords: چاک; ATM; ataxia-telangiectasia mutated; BCL2L1; BCL2 like 1; CGH; comparative genomic hybridization; CHK; checkpoint kinase 1; CIN; chromosomal instability; CNVs; copy number variations; DNMT3B; DNA methyltransferase 3B; DPPA3; developmental pluripotency asso

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

الکل، میکروبیوم، سبک زندگی تاثیر الکل و آسیب اعصاب غیر الکلی

Alcohol, microbiome, life style influence alcohol and non-alcoholic organ damage

Keywords: چاک; ADH; alcohol dehydrogenase; AH; acute alcoholic hepatitis; ALD; alcoholic liver disease; ALT; alanine aminotransferase; ARIC; Atherosclerosis Risk in Communities; ASH; alcoholic steato-hepatitis; AST; aspartate aminotransferase; ATM; ataxia-telangiectasis

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2017 سفارش ترجمه

شگفتی های جدید از علاقه های قدیمی: ظهور تلومراز به عنوان یک بازیکن کلیدی در تنظیم سلول های سرطانی

New surprises from an old favourite: The emergence of telomerase as a key player in the regulation of cancer stemness

Keywords: چاک; Telomerase; TERT; Cancer stemness; CSCs; Positive feedback loops; Targeted anticancer therapy; ABC; ATP-binding cassette; Akt; protein kinase B; ALDH1; aldehyde dehydrogenase 1; BAX; BCL-2-associated protein X; BCL; B-cell lymphoma family protein; BMI-1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

جوان سازی سلولهای پیری - جاده ای که مانع از پیری انسان و بیماری های مرتبط با سن می شود؟

Rejuvenation of senescent cells-The road to postponing human aging and age-related disease?

Keywords: چاک; ATM; ataxia telangiectasia mutated; ATR; ATM and Rad3-related; BMP-2; bone morphogenetic protein-2; Cdk; cyclin-dependent kinase; CESP; cell-type exclusive senescence phenotype; CHK; check point kinase; DDR; DNA damage response; DSBs; double-strand DNA br

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Strategies of biochemical adaptation for hibernation in a South American marsupial, Dromiciops gliroides: 3. Activation of pro-survival response pathways

Keywords: چاک; ATR; ataxia telangiectasia and Rad3 related; Chk; checkpoint kinase; HSP; heat shock protein; H2A.X; histone 2A member X; MDM2; mouse double minute 2; Monito del monte; Hibernation; Metabolic rate depression; Stress response; Cell cycle regulation; Heat s

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

Expression, activation and clinical relevance of CHK1 and CHK2 in metastatic high-grade serous carcinoma

Keywords: چاک; CHK; High-grade serous carcinoma; Effusions; Chemotherapy response; Survival;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Threonine 454 phosphorylation in Grainyhead-like 3 is important for its function and regulation by the p38 MAPK pathway

Keywords: چاک; ATF-2; activating transcription factor 2; BLNK; B-cell linker; CaMK; calcium/calmodulin-dependent protein kinase; CDK; cyclin-dependent kinase; CHK; checkpoint kinase; CK; casein kinase; DNAPK; DNA-dependent protein kinase; EPHX3; epoxide hydrolase 3; ERK

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Integrating plant and animal biology for the search of novel DNA damage biomarkers

Keywords: چاک; ARP; actin related protein; ASK; Arabidopsis SPK1-like; At; Arabidopsis thaliana; ATAF; arabidopsis transcription activation factor; ATM; ataxia telangiectasia mutated; ATR; ATM and Rad3-related; ATRIP; ATR-interacting protein; BARD; BRCA1-associated RING

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments

Keywords: چاک; ABCG2; cATP-binding cassette sub-family G member 2; ALDH1A1; aldehyde dehydrogenase 1A1; ATM; ataxia telangiectasia mutated protein kinase; ATR; ATM-Rad-3-related protein kinase; CD; cluster of differentiation; CSC(s); cancer stem cell(s); Chk; checkpoint

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewChloroethylating nitrosoureas in cancer therapy: DNA damage, repair and cell death signaling

Keywords: چاک; ACNU; 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)- 3-nitrosourea; BCNU; 1,3-bis(2-chloroethyl)-1-nitrosourea; BRCA; breast cancer protein; CCNU; 1-(2-chloroethyl)-3-cyclohexyl-L-nitrosourea; CHK; checkpoint kinase; CNU; chloroethylnitrosour

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD)

Keywords: چاک; 9-1-1 complex; complex of Rad9 Rad1 and Hus1 proteins; A2E; N-retinylidene-N-retinylethanol-amine; AtRal; all-trans retinal; AMD; age-related macular degeneration; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATM; ataxia-telangiectasia

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Src-family tyrosine kinases and the Ca2 + signal

Keywords: چاک; 5-HT6; serotonin receptor 6; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid; ADPR; ADP-ribose; AMPA; α-amino-3-hydr

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2017 سفارش ترجمه

Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics

Keywords: چاک; 53BP1; tumor suppressor p53 binding protein 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related; Chk; checkpoint kinase; DSB; DNA double-strand break; DDR; DNA damage response; DNA-PKcs; DNA-dependent protein kinase, catalyt

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Comprehensive analysis of chemokine-induced cAMP-inhibitory responses using a real-time luminescent biosensor

Keywords: چاک; AC; adenylate cyclase; APC; allophycocyanin; AUC; area under curve; CHK; chemokine; EPAC; exchange protein directly activated by cAMP; FSK; forskolin; HEKgloCX3CR1; HEK293 clone stably expressing CX3CR1 and the GloSensor™ F-22; PDE; phosphodiesterase; P

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

DNA repair targeted therapy: The past or future of cancer treatment?

Keywords: چاک; DNA damage; DNA repair; Cancer; Radiation; Replication protein A; NER; nucleotide excision repair; MMR; DNA mismatch repair; BER; base excision repair; HDR; homology directed repair; FA; Fanconi anemia; HR; homologous recombination; DDR; DNA damage respon

دانلود رایگان متن کامل مقاله ISI 64 صفحه سال انتشار : 2016 سفارش ترجمه

Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis

Keywords: چاک; CHK; CSK (C-terminal Src kinase)-homologous kinase; CLK; Cdc2-like kinase; HIPK; homeodomain-interacting protein kinase; PIM; proviral integration of moloney murine leukemia virus; PKD; protein kinase D; FLT; Fms-like tyrosine kinase; CDK; cyclin-dependen

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Proteomic analysis of cell proliferation in a human hepatic cell line (HL-7702) induced by perfluorooctane sulfonate using iTRAQ

Keywords: چاک; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; iTRAQ; isobaric tags for relative and absolute quantitation; Cdks; cyclin-dependent kinases; Myc; myelocytomatosis oncogene; Myt1; myelin transcription factor 1; Wee1; G2 checkpoint kinase

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Inhibition of C-terminal truncated PPM1D enhances the effect of doxorubicin on cell viability in human colorectal carcinoma cell line

Keywords: چاک; PPM1D; protein phosphatase magnesium-dependent 1, delta; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; Chk; check-point kinase; ARF; alternative reading frame; MTS; 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethox

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Chk1, but not Chk2, is responsible for G2/M phase arrest induced by diallyl disulfide in human gastric cancer BGC823 cells

Keywords: چاک; ATM; ataxia-telangiectasia mutated kinase; ATR; ATM-related protein kinase; Cdc 2; cell division cycle 2; CDK; cyclin-dependent kinase; Chk; checkpoint kinase; DADS; diallyl disulfide; ERK; extracellular signal-regulated kinase; MAPK; mitogen activated pr

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Cetuximab Induces Eme1-Mediated DNA Repair: a Novel Mechanism for Cetuximab Resistance

Keywords: چاک; BRCA1; breast cancer tumor suppressor 1; BrdU; bromodeoxyuridine (5-bromo-2'-deoxyuridine); Chk; checkpoint kinase; DDR; DNA damage response; EGFR; epidermal growth factor receptor; Eme1; essential meiotic endonuclease 1 homolog 1; Erk; extracellular sign

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2014 سفارش ترجمه

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

Keywords: چاک; HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2014 سفارش ترجمه

Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration

Keywords: چاک; MDA; malondialdehyde; 4-HNE; 4-hydroxynonenal; EAE; experimental allergic encephalomyelitis; MS; mutiple sclerosis; SSB; single strand break; DSB; double strand break; 8-OxoG; 8-hydroxyguanosine; 8-NO(2)-G; 8-nitroguanine; AP; apurinic/apyrmidinic; OGG1;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

HMGA2 Inhibits Apoptosis through Interaction with ATR-CHK1 Signaling Complex in Human Cancer Cells

Keywords: چاک; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related kinase; CHK; checkpoint kinase; CICs; cancer-initiating cells; DDR; DNA damage response; DNA-PKc; DNA-dependent protein kinase catalytic subunit; FLICA; Fluorescent Labeled In

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2013 سفارش ترجمه

The role of choline in prostate cancer

Keywords: چاک; CCT; CTP-phosphocholine cytidylyltransferase; CDP-Cho; cytidine diphosphate choline; CHK; choline kinase; CHTs; high-affinity choline transporters; CPT1; diacylglycerol cholinephosphotransferase 1; CTLs; choline transporter-like proteins; CTP; cytidine tr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Channel catfish leukocyte immune-type receptor mediated inhibition of cellular cytotoxicity is facilitated by SHP-1-dependent and -independent mechanisms

Keywords: چاک; IpLITRs; Ictalurus punctatus leukocyte immune-type receptors; SH2; Src homology 2; SHP; Src homology 2 domain-containing cytoplasmic phosphatase; Csk; C-terminal Src kinase; ITAM; immune receptor tyrosine-based activation motif; SFK; Src-family protein ty

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

A novel protein kinase C target site in protein kinase D is phosphorylated in response to signals for cardiac hypertrophy

Keywords: چاک; CHK; checkpoint kinase; CRD; cysteine rich domain; DAG; diacylglycerol; ET-1; endothelin-1; GPCR; G-protein-coupled receptor; GSK-3β; glycogen synthase kinase-3β; HDAC; histone deacetylase; IKK; IκB kinase; ISO; isoproterenol; MARK; microtubule associa

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of novel, selective and potent Chk2 inhibitors

Keywords: چاک; Protein kinase inhibitor; Chk2 inhibitor; Chk; Chk2; DNA damage

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

The DNA damage response during an unperturbed S-phase

Keywords: چاک; A-T; Ataxia-Telangiectasia; ATM; Ataxia-Telangiectasia Mutated; ATR; ATM and Rad3 related (mec1); DSBs; double-strand breaks; ssDNA; single strand DNA; PIKK; phosphoinositol kinase like kinase; IR; ionizing radiation; UV; ultraviolet; HU; hydroxyure

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Csk homologous kinase (CHK), unlike Csk, enhances MAPK activation via Ras-mediated signaling in a Src-independent manner

Keywords: چاک; CHK; Csk; Tyrosine kinase; PC12 cells; Src-family kinases; Neurite outgrowth; NGF; EGF

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases

Keywords: چاک; SFK; Src-family protein tyrosine kinases; CSK; C-terminal Src kinase; CHK; CSK-homologous kinase; SH2 and SH3 domains; Src-homology 2 and Src-homology 3 domains; YT; C-terminal tail regulatory tyrosine of SFKs; YA; autophosphorylated tyrosine in the activ

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه