کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5843895 | 1560945 | 2016 | 64 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DNA repair targeted therapy: The past or future of cancer treatment?
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کلمات کلیدی
HDRRPAMMRPARPBERDNA-PKcsMDSNHEJGG-NERTC-NERDDRERCCPI3Kataxia telangiectasia mutated kinaseAMLFDAATR interacting proteincis-diamminedichloroplatinum (II)SARHTSMre11-Rad50-Nbs1PARPiATRNER - DOWNFpA - FPANAD+ - NAD +xeroderma pigmentosum - pigmentosum xerodermaSSBs - SSBDNA damage - آسیبDNAoligonucleotide/oligosaccharide binding - اتصال الیگونوکلئوتید / اولیگوساکاریدUltraviolet - اشعه فرابنفشcheckpoint kinase - بازرسی کینازionizing radiation - تابش یوننده یا پرتوهای یونیزانDNA repair - ترمیم DNAexcision repair cross-complementing - تعمیر مجدد متقابل مکملnucleotide excision repair - تعمیر مجدد نوکلئوتیدیDNA mismatch repair - تعمیر ناسازگاری DNAbase excision repair - تعمیر پایه پایهreplication protein A - تلقیح پروتئین AATM - خودپردازStructure activity relationship - رابطه فعالیت ساختاریFood and Drug Administration - سازمان غذا و داروCancer - سرطانATRIP - سفرmyelodysplastic syndrome - سندرم میلودیسپلاستیکcisplatin - سیس پلاتینsingle strand breaks - شکاف تک رشته ایHigh throughput screen - صفحه نمایش قدرت بالاnon-homologous end joining - عدم پیوستن انتهای غیر همولوگacute myeloid leukemia - لوسمی حاد میلوئیدی یا به اختصار AMLMRN complex - مجتمع MRNPARP inhibitors - مهار کننده های PARPHomologous recombination - نوترکیبی همولوگNAD, nicotinamide adenine dinucleotide - نیکوتینامید آدنین دینوکلئوتیدhomology directed repair - هماهنگی کارگردانی تعمیرDNA-dependent protein kinase catalytic subunit - وابسته به DNA وابسته به پروتئین کیناز کاتالیزوریDNA damage response - واکنش به آسیب DNA pADPr - پدریRadiation - پرتوPoly(ADP-ribose) - پلی (ADP-ribose)Poly(ADP-ribose) polymerase - پلیمر (ADP-ribose) پلیمرازChk - چاکFanconi anemia - کم خونی Fanconi
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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چکیده انگلیسی
The repair of DNA damage is a complex process that relies on particular pathways to remedy specific types of damage to DNA. The range of insults to DNA includes small, modest changes in structure including mismatched bases and simple methylation events to oxidized bases, intra- and interstrand DNA crosslinks, DNA double strand breaks and protein-DNA adducts. Pathways required for the repair of these lesions include mismatch repair, base excision repair, nucleotide excision repair, and the homology directed repair/Fanconi anemia pathway. Each of these pathways contributes to genetic stability, and mutations in genes encoding proteins involved in these pathways have been demonstrated to promote genetic instability and cancer. In fact, it has been suggested that all cancers display defects in DNA repair. It has also been demonstrated that the ability of cancer cells to repair therapeutically induced DNA damage impacts therapeutic efficacy. This has led to targeting DNA repair pathways and proteins to develop anti-cancer agents that will increase sensitivity to traditional chemotherapeutics. While initial studies languished and were plagued by a lack of specificity and a defined mechanism of action, more recent approaches to exploit synthetic lethal interaction and develop high affinity chemical inhibitors have proven considerably more effective. In this review we will highlight recent advances and discuss previous failures in targeting DNA repair to pave the way for future DNA repair targeted agents and their use in cancer therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 160, April 2016, Pages 65-83
Journal: Pharmacology & Therapeutics - Volume 160, April 2016, Pages 65-83
نویسندگان
Navnath S. Gavande, Pamela S. VanderVere-Carozza, Hilary D. Hinshaw, Shadia I. Jalal, Catherine R. Sears, Katherine S. Pawelczak, John J. Turchi,