Keywords: تلقیح پروتئین A; GO; Gene Ontology; EXP; Inferred from Experiment; IDA; Inferred from Direct Assay; IPI; Inferred from Physical Interaction; IMP; Inferred from Mutant Phenotype; IGI; Inferred from Genetic Interaction; IEP; Inferred from Expression Pattern; DEGs; different
مقالات ISI تلقیح پروتئین A (ترجمه نشده)
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Keywords: تلقیح پروتئین A; MMR; mismatch repair; MSI; microsatellite instability; PCNA; proliferating cellular nuclear antigen; RPA; replication protein A; RFC; replication factor C; EXO1; exonuclease 1; H3K36me3; histone H3 lysine 36 trimethylation; H3K36me3; Histone methylation;
Keywords: تلقیح پروتئین A; DIQ; 1,5-dihydroxyisoquinoline; 4-AN; 4-amino-1,8-naphthalimide; 6,4PPs; 6,4-photoproducts; 8-oxodG; 8-oxo-2â²-deoxyguanosine; OGG1; 8-oxoguanine glycosylase 1; APE1; AP-endonuclease; ATM; ataxia telangiectasia-mutated gene; BER; base excision repair; BR
Keywords: تلقیح پروتئین A; Crystalline lens; Ionizing radiation; DNA repair factors; Nontargeted effects; Inflammation; Tumor suppressors; A-bomb; atomic-bomb; Acvr1; activin A type 1 receptor; AP; apurinic/apyrimidinic; APE1; apurinic/apyrimidinic endonuclease 1; AQP; aquaporin; A
Keywords: تلقیح پروتئین A; 17-AAG; 17-(Allylamino)-17-demethoxygeldanamycin; 17-DMAG; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin; AKT; v-akt murine thymoma viral oncogene homolog; APC; antigen presenting cell; ATM; Ataxia telangiectasia mutated; ATR; Ataxia telangiectasia
Keywords: تلقیح پروتئین A; AD; Alzheimer's disease; AP site; apurinic/apyrimidinic site; APE1; apurinic/apyrimidinic endonuclease 1; Aβ; amyloid beta; BER; base excision repair; CaMKII; Ca2 +/Calmodulin-Dependent Protein Kinase II; CDK; cyclin-dependent kinase; CREB; cAMP respons
The binding efficiency of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units
Keywords: تلقیح پروتئین A; G-quadruplex; Telomere; Replication protein A; Fluorescence resonance energy transfer (FRET); Gel electrophoresis;
Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response
Keywords: تلقیح پروتئین A; APC/C; anaphase-promoting complex or cyclosome; ATM; ataxia-telangiectasia mutated protein; ATR; ataxia-telangiectasia- and rad3-related protein; CDC20; cell division cycle protein 20; CDK; cyclin-dependent kinase; CHK1; checkpoint kinase 1; CHK2; checkpo
Integrating plant and animal biology for the search of novel DNA damage biomarkers
Keywords: تلقیح پروتئین A; ARP; actin related protein; ASK; Arabidopsis SPK1-like; At; Arabidopsis thaliana; ATAF; arabidopsis transcription activation factor; ATM; ataxia telangiectasia mutated; ATR; ATM and Rad3-related; ATRIP; ATR-interacting protein; BARD; BRCA1-associated RING
The role of SMARCAL1 in replication fork stability and telomere maintenance
Keywords: تلقیح پروتئین A; SIOD; Schimke immune-osseous dysplasia; DSB; double-stranded break; ssDNA; single-stranded DNA; RPA; replication protein A; HU; hydroxyurea; BIR; break-induced replication; ALT; alternative lengthening of telomeres; DNA replication; DNA replication stress
DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD)
Keywords: تلقیح پروتئین A; 9-1-1 complex; complex of Rad9 Rad1 and Hus1 proteins; A2E; N-retinylidene-N-retinylethanol-amine; AtRal; all-trans retinal; AMD; age-related macular degeneration; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATM; ataxia-telangiectasia
Regulated expression of the lncRNA TERRA and its impact on telomere biology
Keywords: تلقیح پروتئین A; TERRA; telomere repeat-containing RNA; TRF1/2; telomeric repeat-binding factors 1 and 2; POT1; protection of telomeres 1; TIN2; TRF1-interacting nuclear factor 2; TPP1; adrenocortical dysplasia protein homologue (also called ACD, PTOP, PIP1 & TINT1); RAP1
Valproic acid sensitizes breast cancer cells to hydroxyurea through inhibiting RPA2 hyperphosphorylation-mediated DNA repair pathway
Keywords: تلقیح پروتئین A; VPA; valproic acid; HU; hydroxyurea; IR; ionizing radiation; DSBs; double-strand breaks; HR; homologous recombination; RPA; replication protein A; RPA2-p; hyperphosphorylation of RPA2; wtRPA2; wild-type RPA2; muRPA2; hyperphosphorylation mutant RPA2; HDAC
Cytotoxic platinum coordination compounds. DNA binding agents
Keywords: تلقیح پروتئین A; 1,0,1/t,c,t; [{trans-PtCl(NH3)2}2μ-cis-Pt(NH3)2{H2N(CH2)6NH2}2]4+; 1,0,1/t,t,t; trans-PtCl(NH3)2}2μ-trans-Pt(NH3)2{H2N(CH2)6NH2}2]4+ (BBR3464); 1,1/c,c; [{cis-PtCl(NH3)2}2µ-{H2N(CH2)6NH2}]2+; 1,1/c,c,prz; [{cis-Pt(NH3)2}2(µ-OH)(µ-pyrazolato)]2+; 1,1/
Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics
Keywords: تلقیح پروتئین A; 53BP1; tumor suppressor p53 binding protein 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related; Chk; checkpoint kinase; DSB; DNA double-strand break; DDR; DNA damage response; DNA-PKcs; DNA-dependent protein kinase, catalyt
XPA: A key scaffold for human nucleotide excision repair
Keywords: تلقیح پروتئین A; NER; nucleotide excision repair; XP; Xeroderma pigmentosum; TFIIH; transcription factor II H; RPA; replication protein A; WT; wild type; FL; full-length; AAF; N-(deoxyguanosin-8-yl)-2-acetylaminofluorene; (6-4)PP; (6-4)photoproduct; CPD; cyclobutane pyrim
C-termini are essential and distinct for nucleic acid binding of human NABP1 and NABP2
Keywords: تلقیح پروتئین A; CD; circular dichroism; dsDNA; double-stranded DNA; EMSA; electrophoretic mobility shift assay; HR; homologous recombination; ITC; isothermal titration calorimetry; MS; mass spectrometry; NABP1; nucleic acid binding protein 1; NABP2; nucleic acid binding
Targeting the replisome with transduced monoclonal antibodies triggers lethal DNA replication stress in cancer cells
Keywords: تلقیح پروتئین A; DDR; DNA damage response; DSB; double-strand break; CRISPR; clustered regularly interspaced short palindromic repeats; CSK; cytoskeletal; DTT; dithiothreitol; EdU; 5-ethynyl-2â²-deoxyuridine; EM-CCD; electron multiplying-charge coupled device; γ-H2AX; p
ATR-mediated regulation of nuclear and cellular plasticity
Keywords: تلقیح پروتئین A; ATR; Ataxia Telangiectasia and Rad3-related; PIKK; Phosphatidylinositol 3-Kinase-related Kinases; PTM; Post Translation Modification; ssDNA; single stranded DNA; ATRIP; ATR interacting protein; RPA; Replication Protein A; DDR; DNA damage response; HEAT; H
DNA repair targeted therapy: The past or future of cancer treatment?
Keywords: تلقیح پروتئین A; DNA damage; DNA repair; Cancer; Radiation; Replication protein A; NER; nucleotide excision repair; MMR; DNA mismatch repair; BER; base excision repair; HDR; homology directed repair; FA; Fanconi anemia; HR; homologous recombination; DDR; DNA damage respon
Cancer TARGETases: DSB repair as a pharmacological target
Keywords: تلقیح پروتئین A; DSB repair; Genome instability; Cancer; Kinases; Helicases; Nucleases; ALT; alternative telomere lengthening; AML; acute myeloid leukemia; A-T; ataxia-telangiectasia; ATM; ataxia-telangiectasia mutated; ATP; adenosine triphosphate; ATR; ataxia-tel
Emerging role of protein phosphatases changes the landscape of phospho-signaling in DNA damage response
Keywords: تلقیح پروتئین A; 53BP1; p53 binding protein 1; ATM; ataxia-telangiectasia mutated; ATR; ataxia telangiectasia and Rad3 related; BLM; blooms syndrome RecQ helicase-like, human homolog of SGS1; BRCA1; breast cancer 1, early onset; CDC; cell division cycle; CDK; cyclin depen
ATR signaling cooperates with ATM in the mechanism of low dose hypersensitivity induced by carbon ion beam
Keywords: تلقیح پروتئین A; IR; ionizing radiation; LET; linear energy transfer; HRS; hyper-radiosensitivity; IRR; induced radioresistance; DSB; DNA double strand break; ATM; ataxia telangiectasia mutated homolog; ATR; ataxia telangiectasia and Rad3 related; DNA-PKcs; DNA-dependent
APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER
Keywords: تلقیح پروتئین A; Sensory neuronal cultures; Cisplatin damage; APE1; Replication protein A; Nucleotide excision repair; Base excision repair;
Chemical inhibitor targeting the replication protein A–DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer
Keywords: تلقیح پروتئین A; DNA repair; Cisplatin; Combination therapy; Drug discovery; Replication protein A
Quality control mechanisms in cellular and systemic DNA damage responses
Keywords: تلقیح پروتئین A; DNA damage; Ageing; Ubiquitin proteasome system; DNA repair; Progeroid syndromes; Genome stability; ARF; adenosine diphosphate ribosylation factor; AT; ataxia telangiectasia; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; BER; base excis
Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
Keywords: تلقیح پروتئین A; DTT; dithiothreitol; EGTA; ethylene glycol tetraacetic acid; FACS; fluorescence-activated cell sorting; HA; human influenza hemagglutinin; HCD; higher-energy collisional dissociation; HPLC; high performance liquid chromatography; PCNA; proliferating cellu
TIPIN depletion leads to apoptosis in breast cancer cells
Keywords: تلقیح پروتئین A; Apoptosis; Basal-like; Replicative stress; Therapeutic target; TIPIN; Triple-negative breast cancer; 2D; 2-dimensional; 3D; 3-dimensional; BC; breast cancer; BrdU; 5-bromo-2â²-deoxyuridine; CldU; 5-chloro-2â²-deoxyuridine; CN; copy number; DSBs; DNA dou
Interplay of DNA damage and cell cycle signaling at the level of human replication protein A
Keywords: تلقیح پروتئین A; AT; ataxia telangiectasia; ATM; ataxia telangiectasia mutated kinase; ATR; ataxia telangiectasia and Rad3-related kinase; ATRIP; ATR-interacting protein; CDK; cyclin-dependent kinase; CIP; calf intestinal phosphatase; DDR; DNA damage response; DNA-PKcs; D
Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
Keywords: تلقیح پروتئین A; HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki
DNA doubleâstrand break response in stem cells: Mechanisms to maintain genomic integrity
Keywords: تلقیح پروتئین A; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; BRCA1; breast cancer type 1 susceptibility protein; CtBP; C-terminal binding protein; CtIP; CTBP interacting protein; DDR; DNA damage response; DNA-PK; DNA-dependent
DNA repair mechanisms in dividing and non-dividing cells
Keywords: تلقیح پروتئین A; DNA repair; Neural cells; Neurological disorder; Dividing and non-dividing; Endogenous DNA damage; AOA1; ataxia with ocular motor apraxia 1; AP; apurinic/apyrimidinic; APE1; AP endonuclease 1; APTX; aprataxin; ATM; ataxia telangiectasia mutated; CPDs; cyc
Studying the protein expression in human B lymphoblastoid cells exposed to 1.8-GHz (GSM) radiofrequency radiation (RFR) with protein microarray
Keywords: تلقیح پروتئین A; Apoptosis; DNA repair; Radiofrequency radiation; Replication Protein A; p73; Protein microarray
RPA provides checkpoint-independent cell cycle arrest and prevents recombination at uncapped telomeres of Saccharomyces cerevisiae
Keywords: تلقیح پروتئین A; Budding yeast; cdc13-1 mutation; Checkpoint-mediated cell cycle control; Replication Protein A; Telomeric DNA damage
Implication of RPA32 phosphorylation in S-phase checkpoint signalling at replication forks stalled with aphidicolin in Xenopus egg extracts
Keywords: تلقیح پروتئین A; ATR; Replication stress; Chk1; Replication protein A;
The BRCA1 alternative splicing variant Î14-15 with an in-frame deletion of part of the regulatory serine-containing domain (SCD) impairs the DNA repair capacity in MCF-7 cells
Keywords: تلقیح پروتئین A; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related; AURKA; Aurora kinase A; BC; breast cancer; BRCA1/2; breast cancer-associated gene 1/2; BRCT; BRCA1 C-terminal domain; B2M; beta-2-microglobulin; Cdk2; cyclin-dependent kinase
Purification of replication factors using insect and mammalian cell expression systems
Keywords: تلقیح پروتئین A; ORC; origin recognition complex; Mcm; minichromosome maintenance; Cdc45; cell division cycle 45; RPA; replication protein A; Tipin; tim-interacting protein; pre-RC; pre-replicative complex; ssDNA; single-stranded DNA; dsDNA; double-stranded DNA; DNA repli
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA
Keywords: تلقیح پروتئین A; AID; activation-induced cytidine deaminase; AP; apurinic/apyrimidinic; BER; base excision repair; CSR; class-switch recombination; ESI-MS; electrospray ionization mass spectrometry; HIGM syndrome; hyper-IgM syndrome; LCL; lymphoblastoid cell line; MALDI-T
DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease
Keywords: تلقیح پروتئین A; RPA; replication protein A; WRN; Werner syndrome protein; WS; Werner syndrome; dsDNA; double-stranded DNA; WRN helicases; DNA secondary structure; DNA unwinding;
Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods
Keywords: تلقیح پروتئین A; Replication Protein A; Inhibitors; High-throughput screen; EMSA; DockingDNA, deoxyribonucleic acid; DDR, DNA damage response; BER, base excision repair; HRR, homologous recombination repair; SMI, small molecule inhibitor; RPA, Replication Protein A; kDa,
IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest
Keywords: تلقیح پروتئین A; APC; adenomatous polyposis coli; DMSO; dimethyl sulphoxide; GFP; green fluorescent protein; GSK-3β; glycogen synthase kinase-3β; IQGAP1; IQ-domain GTPase activating protein 1; PCNA; proliferating cell nuclear antigen; RNA Polymerase II; RNA Pol II; RPA;
Regulation of homologous recombination at telomeres in budding yeast
Keywords: تلقیح پروتئین A; Homologous recombination (HR); Recombinational telomere elongation (RTE); Replicative senescence; Rad52; Replication protein A; Cdc13;
Roles of Werner syndrome protein in protection of genome integrity
Keywords: تلقیح پروتئین A; γ-H2AX; phosphorylated histone H2AX; 4-NQO; 4-nitroquinoline 1-oxide; 5-OHdC; 5-hydroxycytidine; 5-OHU; 5-hydroxyuracil; 8-oxodA; 8-oxoadenine; 8-oxodG; 8-oxoguanine; ALT; alternative lengthening of telomeres; APE1; apurinic/apyrimidinic endonuclease 1;
RPA nucleic acid-binding properties of IFI16-HIN200
Keywords: تلقیح پروتئین A; Oligonucleotide/oligosaccharide binding fold; Replication protein A; HIN200; IFI16; EMSA; Circular dichroism; FRET
Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase η-deficient human cells treated with cisplatin and oxaliplatin
Keywords: تلقیح پروتئین A; ICL; interstrand crosslink; ATM; ataxia telangiectasia mutated; ATR; ATM and Rad3-related; ATRIP; ATR interacting protein; PIKK; PI-3 kinase-related protein kinase; DNA-PK; DNA-dependent protein kinase; Polη; DNA polymerase η; RPA; replication protein A
Different activities of the largest subunit of replication protein A cooperate during SV40 DNA replication
Keywords: تلقیح پروتئین A; SV40 DNA replication; Replication protein A; Protein-protein interaction;
Distinct activities of the related protein kinases Cdk1 and Ime2
Keywords: تلقیح پروتئین A; Cyclin-dependent kinase; G1 cyclin; Meiosis; Phosphorylation; Replication protein A; Sic1
Mobility and distribution of replication protein A in living cells using fluorescence correlation spectroscopy
Keywords: تلقیح پروتئین A; Genome stability; DNA replication; DNA repair; Replication protein A; Green fluorescent protein; Fluorescence correlation spectroscopy (FCS); Laser scanning microscopy (LSM)
The nuclear DNA deaminase AID functions distributively whereas cytoplasmic APOBEC3G has a processive mode of action
Keywords: تلقیح پروتئین A; AID; activation induced cytidine deaminase; hAID; human activation induced cytidine deaminase; Ig; immunoglobulin; SHM; somatic hypermutation; CSR; class-switch recombination; GC; gene conversion; ung; uracil N-glycosylase; MBP; maltose binding protein; W
Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A
Keywords: تلقیح پروتئین A; Differential scanning calorimetry; Xeroderma pigmentosum group A protein; Replication protein A; Cisplatin; DNA adducts; DNA distortion; Electrophoretic mobility shift assay; Thermodynamic stability;