کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10872567 1074179 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Different activities of the largest subunit of replication protein A cooperate during SV40 DNA replication
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Different activities of the largest subunit of replication protein A cooperate during SV40 DNA replication
چکیده انگلیسی
Replication protein A (RPA) is a stable heterotrimeric complex consisting of p70, p32 and p14 subunits. The protein plays a crucial role in SV40 minichromosome replication. Peptides of p70 representing interaction sites for the smaller two subunits, DNA as well as the viral initiator protein large T-antigen (Tag) and the cellular DNA polymerase α-primase (Pol) all interfered with the replication process indicating the importance of the different p70 activities in this process. Inhibition by the peptide disrupting protein-protein interactions was observed only during the pre-initiation stage prior to primer synthesis, suggesting the formation of a stable initiation complex between RPA, Tag and Pol at the primer end.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 21, 21 August 2007, Pages 3973-3978
نویسندگان
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