The role of choline in prostate cancer

► Choline is an essential nutrient with a potential role in prostate cancer. ► Choline uptake and turn over are increased in cancer cells. ► Choline is a source of methyl groups that contribute to carcinogenesis. ► Several enzymes in choline metabolism are overexpressed in cancer. ► Hormones and hypoxia contribute to altered choline metabolism in prostate cancer.