کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1968448 1538860 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Δ9-Tetrahydrocannabinol concentrations in exhaled breath and physiological effects following cannabis intake – A pilot study using illicit cannabis
ترجمه فارسی عنوان
غلظت های Δ9-Tetrahydrocannabinol در نفس کشنده و اثرات فیزیولوژیکی پس از مصرف شاهدانه؛ یک مطالعه آزمایشی با استفاده از شاهنامه غیرقانونی
کلمات کلیدی
LOD، محدودیت تشخیص؛ LOQ، محدودیت اندازه گیری؛ LLOQ، حد پایین تر از مقدار سنجی؛ THC، Δ9-tetrahydrocannabinol؛ THC-D3، Δ9-tetrahydrocannabinol-D3؛ THCCOOH، 11-nor-9-carboxy-Δ9-tetrahydrocannabinolCannabis؛ تست داروی تنفس؛ سیگار کشیدن ماریجوانا
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• THC breath concentration was higher than before smoking for up to 120 min
• Breath THC remained detectable for at least 3 h after smoking in all participants
• The pulse rate was increased and the pupil diameter decreased for 30 minutes after smoking
• There was a high inter-individual variability in the breath THC concentrations
• The presence of THC in the samples before smoking needs to be investigated further

ObjectivesΔ9-Tetrahydrocannabinol (THC) can be measured in exhaled breath by using an aerosol particle collection device. The sampling procedure is simple, non-invasive and takes only 2–3 min. In the present study we measured the amount of THC in exhaled breath of cannabis users at specific time intervals up to 3 h after smoking one cannabis cigarette.Design and methodsThe breath concentration-effect relationship was studied by measuring the pulse rate and the pupil diameter to assess physiological changes. THC and the main metabolite 11-nor-9-carboxy-Δ9-tetrahydrocannabinol were analyzed in exhaled breath by a liquid chromatography-tandem mass spectrometry method. Thirteen subjects (9 males and 4 females, aged 23–24 years) participated. Five of those were using cannabis more frequently than monthly.ResultsTHC was detected in most subjects already at baseline, concentrations increased following smoking and remained detectable for over 3 h (mean THC concentration in breath at 3 h: 1479 pg/sample). Pulse rate (p = 0.015) and pupil diameter (p = 0.044) were significantly altered up to 30 min after smoking. The detection window of cannabis in breath after smoking one cannabis cigarette in occasional and chronic smokers was at least 3 h. Only THC was detected, and not the metabolite. The THC concentration in exhaled breath was related to the physiological changes that occur over time.ConclusionsExhaled breath can be used to detect recent cannabis exposure.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 49, Issues 13–14, September 2016, Pages 1072–1077
نویسندگان
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