Keywords: LLOQ، حد پایین تر از مقدار سنجی; BLM, bleomycin; LLOQ, lower limit of quantification; QTOF, hybrid quadrupole coupled to TOF MS; BLM-A2-Cu, bleomycin A2 fraction copper complex; BLM-B2-Cu, bleomycin B2 fraction copper complex; MeOH, methanol; ACN, acetonitrileBleomycin; Liquid chromatogr
مقالات ISI LLOQ، حد پایین تر از مقدار سنجی (ترجمه نشده)
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Keywords: LLOQ، حد پایین تر از مقدار سنجی; E1, estrone; E2, 17β-estradiol; G, β-glucuronide; GC, gas chromatography; LC, liquid chromatography; HQC, high quality control; LLE, liquid–liquid extraction; LLOQ, lower limit of quantification; LQC, low quality control; MQC, medium quality control; MS,
Keywords: LLOQ، حد پایین تر از مقدار سنجی; ABTS, 2,2′-azino-di-[3-ethylbenzthiazoine-sulfonate]; HRP, horseradish peroxidase; LLOD, lower limit of detection; LLOQ, lower limit of quantification; LOD, l-lactate oxidase; LA, l-lactate concentrationAutomated screening for lactic acid productionl-Lact
Keywords: LLOQ، حد پایین تر از مقدار سنجی; DBS, dried blood spot; EMA, European Medicines Agency; FDA, Food and Drug Administration; LLOQ, lower limit of quantification; ME, matrix effect; RSD, relative standard deviation; QC, quality control sample; QCl, quality control sample of 15 μg/L (low con
Keywords: LLOQ، حد پایین تر از مقدار سنجی; LC/MS/MS, liquid chromatography/tandem mass spectrometry; LLOQ, lower limit of quantification; OATP, organic anion transporting polypeptide; SLC, solute carrier; SRM, selected reaction monitoringDigoxin; Ouabain; LC/MS/MS; Intracellular measurement; Extra
Keywords: LLOQ، حد پایین تر از مقدار سنجی; Ganciclovir (PubChem CID: 3454)GCL, ganciclovir; API, active pharmaceutical ingredient; AQC, analytical quality control; CMV, cytomegalovirus; HPLC, high-performance liquid chromatography; LLOQ, lower limit of quantification; LoA, limits of acceptability;
Keywords: LLOQ، حد پایین تر از مقدار سنجی; UPLC, ultra-performance liquid chromatography; MS, mass spectrometry; MRM, multiple reaction monitoring; APCI, atmospheric pressure chemical ionization; HPLC, high performance liquid chromatography; LLOQ, lower limit of quantification; IS, internal standa
Keywords: LLOQ، حد پایین تر از مقدار سنجی; LOD, limit of detection; LOQ, limit of quantification; LLOQ, lower limit of quantification; THC, Δ9-tetrahydrocannabinol; THC-D3, Δ9-tetrahydrocannabinol-D3; THCCOOH, 11-nor-9-carboxy-Δ9-tetrahydrocannabinolCannabis; Breath drug testing; Marijuana smoking
LC–MS/MS determination and urinary excretion study of seven alkaloids in healthy Chinese volunteers after oral administration of Shuanghua Baihe tablets
Keywords: LLOQ، حد پایین تر از مقدار سنجی; SBT, Shuanghua Baihe tablets; IS, internal standard; LLOQ, lower limit of quantification; LQC, low QC; MQC, medium QC; HQC, high QC; MRM, multiple reaction monitoring; RE, relative errorBerberine; Berberrubine; LC–MS/MS; Magnoflorine; Shuanghua Baihe tabl
A sensitive high performance liquid chromatography assay for the quantification of doxorubicin associated with DNA in tumor and tissues
Keywords: LLOQ، حد پایین تر از مقدار سنجی; CV%, coefficient of variation; DNA, deoxyribonucleic acid; Dox, doxorubicin; dsDNA, double-stranded DNA; HPLC, high performance liquid chromatography; IV, intravenous; LLOQ, lower limit of quantification; NMR, nuclear magnetic resonance; PK, pharmacokinet
Development and validation of an HPLC–MS/MS method to determine clopidogrel in human plasma
Keywords: LLOQ، حد پایین تر از مقدار سنجی; ESI, electrospray ionization; IS, internal standard; LC–MS/MS, liquid chromatography tandem mass spectrometry; LLOQ, lower limit of quantification; MRM, multiple reaction monitoring; SPE, solid phase extraction; QC, quality controlClopidogrel; Online-SPE;
An improved microbore UHPLC method with electrochemical detection for the simultaneous determination of low monoamine levels in in vivo brain microdialysis samples
Keywords: LLOQ، حد پایین تر از مقدار سنجی; 5-HT, serotonin; DA, dopamine; DoE, design of experiments; ECD, electrochemical detection; LLOQ, lower limit of quantification; LOD, limit of detection; LOF, lack of fit; MS/MS, tandem mass spectrometry; NA, noradrenaline; POISe, performance optimizing in
Simultaneous determination of tazarotene and its active metabolite tazarotenic acid in minipig plasma by LC–MS/MS and its application in pharmacokinetic study after topical administration of tazarotene gel
Keywords: LLOQ، حد پایین تر از مقدار سنجی; LLOQ, lower limit of quantification; QC, quality control; BSA, body surface area; BW, body weight; LLE, liquid–liquid extractionTazarotene; Tazarotenic acid; LC–MS/MS; Systemic exposure; Transdermal administration
Determination of efonidipine in human plasma by LC–MS/MS for pharmacokinetic applications
Keywords: LLOQ، حد پایین تر از مقدار سنجی; DHP, dihydropyridine; HR, heart rate; CKD, chronic kidney disease; BP, blood pressure; IS, internal standard; LLOQ, lower limit of quantification; QC, quality control; ULOQ, upper limit of quantification; ESI, electrospray ionization; DP, declustering pot
Quantification of new antiepileptic drugs by liquid chromatography/electrospray ionization tandem mass spectrometry and its application to cellular uptake experiment using human placental choriocarcinoma BeWo cells
Keywords: LLOQ، حد پایین تر از مقدار سنجی; GBP, gabapentin; IS, internal standard; LC/MS/MS, liquid chromatography/tandem mass spectrometry; LEV, levetiracetam; LLOQ, lower limit of quantification; LTG, lamotrigine; R.E., relative error; R.S.D., relative standard deviation; SRM, selected reaction
Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies
Keywords: LLOQ، حد پایین تر از مقدار سنجی; UPLC, ultra-performance liquid chromatography; I.S., internal standard; DP, declustering potential; CE, collision energy; CXP, collision cell exit potential; AUC, area under the curve; QC, quality control; LLOQ, lower limit of quantification; MPA, mobile
Quantification of 5,7-dimethoxyflavone in mouse plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) and its application to a pharmacokinetic study
Keywords: LLOQ، حد پایین تر از مقدار سنجی; 5,7-DMF, 5,7-dimethoxyflavone; LC–MS/MS, liquid chromatography–tandem mass spectrometry; PK, pharmacokinetics; LLOQ, lower limit of quantification; HPLC, high performance liquid chromatography; GC, gas chromatography; TMF, 5,7,4′-trimethoxyflavone; ACN, a
Method development for quantification of the environmental neurotoxin annonacin in Rat plasma by UPLC–MS/MS and application to a pharmacokinetic study
Keywords: LLOQ، حد پایین تر از مقدار سنجی; AAG, Annonaceous acetogenin; amu, atomic mass unit; AUC, area under curve; Cl, clearance; EMA, Eropean Medicines Agency; F, obsapparent bioavailability; IS, internal standard; LLOQ, lower limit of quantification; MF, matrix factor; MQC, medium concentrati
Bio-analytical method based on MALDI-MS analysis for the quantification of CIGB-300 anti-tumor peptide in human plasma
Keywords: LLOQ، حد پایین تر از مقدار سنجی; MALDI-TOF MS, Matrix Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry; QCs, quality control samples; CSs, calibration standard samples; TFA, trifluoroacetic acid; IS, internal standard; LLOQ, lower limit of quantification; AUC, area u
LC-ESI–MS/MS method for bioanalytical determination of osteogenic phytoalexin, medicarpin, and its application to preliminary pharmacokinetic studies in rats
Keywords: LLOQ، حد پایین تر از مقدار سنجی; ESI, electrospray ionization; IS, internal standard; LC, liquid chromatography; LLOQ, lower limit of quantification; MRM, multiple reaction monitoring; SD, Sprague–Dawley; Vd, volume of distribution; Cl, clearanceBioavailability; Pharmacokinetics; Bioanal
On-cartridge derivatization coupled with solid-phase extraction for the ultra-sensitive determination of minodronic acid in human plasma by LC–MS/MS method
Keywords: LLOQ، حد پایین تر از مقدار سنجی; AA, alendronic acid; BP, bisphosphonate; D4-MA, D4-minodronic acid; HQC, high QC; IMF, IS-normalized matrix factor; IS, internal standard; LLOQ, lower limit of quantification; LQC, low QC; MA, minodronic acid; MQC, medium QC; MRM, multiple reaction monito
A semi-automated mass spectrometric immunoassay coupled to selected reaction monitoring (MSIA–SRM) reveals novel relationships between circulating PCSK9 and metabolic phenotypes in patient cohorts
Keywords: LLOQ، حد پایین تر از مقدار سنجی; PCSK9, proprotein convertase subtilisin/kexin type 9; LDL-C, low density lipoprotein cholesterol; PTM, posttranslational modification; MSIA–SRM, mass spectrometric immunoassay coupled to selected reaction monitoring; LLOQ, lower limit of quantification; L
Pharmacokinetic study of salvianolic acid D after oral and intravenous administration in rats
Keywords: LLOQ، حد پایین تر از مقدار سنجی; AUC, the area under curve; CI, confidence interval; CL, clearance; Cmax, peak plasma concentration; ECE-1, endothelin converting enzyme 1; ESI, electrospray ionization; IS, internal standard; LLOQ, lower limit of quantification; QC, quality control; R.E.,
Comparison of three quantitative HCV RNA assays in samples from HCV genotype 1- or 4-infected patients treated with the NS3/4A protease inhibitor simeprevir
Keywords: LLOQ، حد پایین تر از مقدار سنجی; ART, Abbott RealTime HCV; CAP, Roche AmpliPrep COBAS® TaqMan® HCV v2.0; DAA, direct-acting antiviral agent; GT, genotype; HCV, hepatitis C virus; HPS, Roche High-Pure-System COBAS® TaqMan® HCV v2.0; LLOQ, lower limit of quantification; LOD, limit of detec
Pharmacokinetics and tissue distribution study of Isovitexin in rats by HPLC-MS/MS
Keywords: LLOQ، حد پایین تر از مقدار سنجی; Isovitexin; HPLC-MS/MS; Pharmacokinetics; Tissue distributionIS, internal standard; MRM, multiple reaction monitoring; SD, Sprague Dawley; ESI, electrospray ionization; LLOQ, lower limit of quantification; QC, quality control; CE, collision energy; RSD, r
Validation of a UPLC–MS/MS method for the simultaneous determination of E6005, a phosphodiesterase 4 inhibitor, and its metabolite in human plasma
Keywords: LLOQ، حد پایین تر از مقدار سنجی; HQ, Chigh QC; IS, internal standard; LLOQ, lower limit of quantification; LQC, low QC; MQC, middle QC; PDE, phosphodiesterase; QC, quality control; RE, relative error; RSD, relative standard deviations; ULOQ, upper limit of quantification; UPLC–MS/MS, ult
Pharmacokinetics and tissue distribution of Aucubin, Ajugol and Catalpol in rats using a validated simultaneous LC–ESI-MS/MS assay
Keywords: LLOQ، حد پایین تر از مقدار سنجی; HPLC–ESI–MS/MS, high-performance liquid chromatography–electro spray ionization tandem mass spectrometry; MRM, multiple-reaction monitoring; LLOQ, lower limit of quantification; ULOQ, upper limit of quantification; TCM, traditional Chinese medicines; IS,
Highly sensitive method for simultaneous determination of nine alkaloids of Shuanghua Baihe tablets in human plasma by LC–MS/MS and its application
Keywords: LLOQ، حد پایین تر از مقدار سنجی; SBT, Shuanghua Baihe tablets; RAS, recurrent aphthous stomatitis; TCM, traditional Chinese medicine; TCMs, traditional Chinese medicines; LLOQ, lower limit of quantification; IS, internal standard; MRM, multiple reaction monitoring; PPT, protein precipita
Validation and clinical evaluation of a UHPLC method with fluorescence detector for plasma quantification of doxorubicin and doxorubicinol in haematological patients
Keywords: LLOQ، حد پایین تر از مقدار سنجی; DOX, doxorubicin; PK/PD, pharmacokinetic–pharmacodynamic; TDM, therapeutic drug monitoring; DOXol, doxorubicinol; DAU, daunorubicin; LLOQ, lower limit of quantification; CV, coefficient of variation; LQC, low-quality control; MQC, medium-quality control;
A sensitive and robust HPLC assay with fluorescence detection for the quantification of pomalidomide in human plasma for pharmacokinetic analyses
Keywords: LLOQ، حد پایین تر از مقدار سنجی; HPLC, high performance liquid chromatography; IMiD, immunomodulatory drug; QC, quality control; LLOQ, lower limit of quantification; IS, internal standard; MM, multiple myelomaPomalidomide; HPLC; Fluorescence; Pharmacokinetics; Liquid extraction
A quantitative LC–MS/MS method for determination of thiazolidinedione mitoNEET ligand NL-1 in mouse serum suitable for pharmacokinetic studies
Keywords: LLOQ، حد پایین تر از مقدار سنجی; %CV, percent coefficient of variation; IS, internal standard; LLOQ, lower limit of quantification; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MRM, multiple reaction monitoring; NL-1, 5-[3,5-di-tert-butyl-4-hydroxyphenyl)methyl]-1,3-thiazolidine-2
A liquid chromatography-mass spectrometry assay for quantification of Exendin[9-39] in human plasma
Keywords: LLOQ، حد پایین تر از مقدار سنجی; HI, Hyperinsulinism; GLP-R, Glucagon-like peptide-1 receptor; DPP-4, Dipeptidyl peptidase-4; SPE, Solid-phase extraction; SRM, Selected reaction monitoring; LLOQ, Lower limit of quantification; ULOQ, Upper limit of quantification; SD, Standard DeviationEx
A quantitative LC-MS/MS method for determination of SP-141, a novel pyrido[b]indole anticancer agent, and its application to a mouse PK study
Keywords: LLOQ، حد پایین تر از مقدار سنجی; %CV, percent coefficient of variation; RE, relative error; IS, internal standard; LLOQ, lower limit of quantification; MRM, multiple reaction monitoring; QC, quality control; SD, standard deviation; SP-141, 6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]in
Simultaneous determination of oxiracetam and its degraded substance in rat plasma by HPLC-MS/MS and its application to pharmacokinetic study after a single high-dose intravenous administration
Keywords: LLOQ، حد پایین تر از مقدار سنجی; HOPAA, 4-hydroxy-2-oxo-1-pyrrolidine acetic acid; IS, internal standard; MRM, multiple reaction monitoring; ESI, electrospray ionization; QC, quality control; LLOQ, lower limit of quantification; RE, relative error; RSD, relative standard deviation.Simult
Quantitative determination of mithramycin in human plasma by a novel, sensitive ultra-HPLC–MS/MS method for clinical pharmacokinetic application
Keywords: LLOQ، حد پایین تر از مقدار سنجی; UHPLC, ultra-high performance liquid chromatography; MS, mass spectrometry; MS/MS, tandem mass spectrometry; QC, quality control; LLOQ, lower limit of quantification; SPE, solid-phase extraction; NIH, National Institutes of Health; NCI, National Cancer In
In vitro permeability of a model protein across ocular tissues and effect of iontophoresis on the transscleral delivery
Keywords: LLOQ، حد پایین تر از مقدار سنجی; FD-150, fluorescein isothiocyanate dextran (MW 120 kDa); HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; EO, electroosmosis; ER, electrorepulsion; LOD, limit of detection; LLOQ, lower limit of quantification; EF, enhancement factor; IF, inhibit
Absolute quantification of podocin, a potential biomarker of glomerular injury in human urine, by liquid chromatography–multiple reaction monitoring cubed mass spectrometry
Keywords: LLOQ، حد پایین تر از مقدار سنجی; Protein; Biomarker; Quantification; Podocin; Urine; MRM3ELISA, enzyme-linked immuno sorbent assay; SRM, selected reaction monitoring; MRM3, multiple reaction monitoring cubed; LLOQ, lower limit of quantification; LC–MS, liquid chromatography–mass spectrom
Identification of urinary miRNA biomarkers for detecting cisplatin-induced proximal tubular injury in rats
Keywords: LLOQ، حد پایین تر از مقدار سنجی; miRNA, microRNA; mRNA, messenger RNA; BUN, blood urea nitrogen; CREA, creatinine; Kim-1, kidney injury molecule-1; TLDA A and B cards, TaqMan® MicroRNA Rodent A and B cards; LLOQ, lower limit of quantification; UVRQ, relative quantity normalized by urine
Liquid chromatography–tandem mass spectrometric assay for the mutated BRAF inhibitor dabrafenib in mouse plasma
Keywords: LLOQ، حد پایین تر از مقدار سنجی; AUC, area under the plasma concentration–time curve; LLOQ, lower limit of quantification; SRM, selected reaction monitoring; T1/2, elimination half-life; QC, quality controlDabrafenib; Mutated BRAF inhibitor; LC–MS/MS; plasma
Simultaneous quantification of individual intermediate steroids in silkworm ecdysone biosynthesis by liquid chromatography–tandem mass spectrometry with multiple reaction monitoring
Keywords: LLOQ، حد پایین تر از مقدار سنجی; 2dE, 2-deoxyecdysone; 20E, 20-hydroxyecdysone; 7dC, 7-dehydrocholesterol; C, cholesterol; E, ecdysone; LLOQ, lower limit of quantification; KD, 5β-ketodiol (2,22,25-trideoxyecdysone); KT, 5β-ketotriol (2,22-dideoxyecdysone); MRM, multiple reaction monitor
A rapid ultra HPLC–MS/MS method for the quantitation and pharmacokinetic analysis of 3-deazaneplanocin A in mice
Keywords: LLOQ، حد پایین تر از مقدار سنجی; DZNep, 3-deazaplanocin A; uHPLC, ultra-high performance liquid chromatography; MS, mass spectrometry; MS/MS, tandem mass spectrometry; QC, quality control; LLOQ, lower limit of quantification; IS, internal standard3-Deazaneplanocin; Ultra HPLC–MS/MS; Phar
Quantitative determination of human interleukin 22 (IL-22) in serum using Singulex-Erenna® Technology
Keywords: LLOQ، حد پایین تر از مقدار سنجی; IL-22, interleukin-22; Sera, human serum; LLOQ, lower limit of quantification; ULOQ, upper limit of quantification; CV, coefficient of variance; SD, standard deviation; MP, magnetic microparticles; STD, standard reference material; QC, quality controlBiom
Quantification of intact carboplatin in human plasma ultrafitrates using hydrophilic interaction liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study
Keywords: LLOQ، حد پایین تر از مقدار سنجی; HILIC, hydrophilic interaction chromatography; LLOQ, lower limit of quantification; SRM, selected reaction monitoringCarboplatin; Hydrophilic interaction liquid chromatography–tandem mass spectrometry; Plasma ultrafiltrates
In vivo disposition and metabolism of madecassoside, a major bioactive constituent in Centella asiatica (L.) Urb.
Keywords: LLOQ، حد پایین تر از مقدار سنجی; IS, Internal standard; P-gp, P-glycoprotein; MRP2, Multidrug resistance-associated protein; LC-TOF-MS, Liquid chromatography coupled with time-of-flight mass spectrometry; LLOQ, Lower limit of quantification; QC, Quality controlMadecassoside; Tissue distr
Development of an HPLC fluorescence method for determination of boldine in plasma, bile and urine of rats and identification of its major metabolites by LC–MS/MS
Keywords: LLOQ، حد پایین تر از مقدار سنجی; BOL, boldine; CID, collision induced dissociation; CV, coefficient of variation; DCM, dichloromethane; EMEA, European Medicines Agency; FLD, fluorescence detection; LLOQ, lower limit of quantification; MEOTA, 7-methoxytacrine; RE, relative error; RPM, rev
Ultra high performance liquid chromatography-quadrupole-time of flight analysis for the identification and the determination of resveratrol and its metabolites in mouse plasma
Keywords: LLOQ، حد پایین تر از مقدار سنجی; ACN, acetonitrile; CV, coefficient of variation; DEV, deviation; ESI, electrospray ionization; FA, formic acid; HPLC, high performance liquid chromatography; IS, internal standard; IV, intravenous; LLOQ, lower limit of quantification; MeOH, methanol; MRM,
Performance evaluation of canine-associated Bacteroidales assays in a multi-laboratory comparison study
Keywords: LLOQ، حد پایین تر از مقدار سنجی; Quantitative PCR; Microbial source tracking; Bacteroidales; Canine fecal pollutioncp, gene copy numbers; Ct, cycle threshold; DNQ, detected but not quantifiable; FIB, fecal indicator bacteria; LLOQ, lower limit of quantification; LOD, limit of detection;
Liquid chromatography–tandem mass spectrometric assay for therapeutic drug monitoring of the tyrosine kinase inhibitor pazopanib in human plasma
Keywords: LLOQ، حد پایین تر از مقدار سنجی; Pazopanib; VEGFR; LC–MS/MS; Human plasma; Therapeutic drug monitoringDMSO, dimethylsulfoxide; HESI, heated electrospray ionization; VEGF, vascular endothelial growth factor; LLOQ, lower limit of quantification; PP, polypropylene; SRM, selected reaction mo
Liquid chromatography–tandem mass spectrometric assay for the mutated BRAF inhibitor vemurafenib in human and mouse plasma
Keywords: LLOQ، حد پایین تر از مقدار سنجی; HESI, heated electrospray ionization; LLOQ, lower limit of quantification; SRM, selected reaction monitoring; QC, quality controlVemurafenib; Mutated BRAF inhibitor; LC–MS/MS; Plasma
Liquid chromatography–tandem mass spectrometric assay for the JAK2 inhibitor CYT387 in plasma
Keywords: LLOQ، حد پایین تر از مقدار سنجی; HESI, heated electrospray ionization; JAK, Janus kinase; LLOQ, lower limit of quantification; SRM, selected reaction monitoring; QC, quality controlCYT387; JAK2 inhibitor; LC–MS/MS; Human plasma; Mouse plasma