دانلود مقالات ISI درباره LLOQ، حد پایین تر از مقدار سنجی + ترجمه فارسی

Liquid chromatography–tandem mass spectrometric assay for the VEGFR inhibitor cediranib and its primary human metabolite cediranib-N+-glucuronide in plasma

Keywords: LLOQ، حد پایین تر از مقدار سنجی; HESI, heated electrospray ionization; LLOQ, lower limit of quantification; SRM, selected reaction monitoring; QC, quality control; VEGFR, vascular endothelial growth factor receptorCediranib; Cediranib-N+-glucuronide; VEGF inhibitor; LC–MS/MS; Human plasm

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Liquid chromatography–tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma

Keywords: LLOQ، حد پایین تر از مقدار سنجی; ALK, anaplastic lymphoma kinase; AUC, area-under-the-plasma-time curve; HESI, heated electrospray ionization; ka, absorption rate; LLOQ, lower limit of quantification; NSCLC, non-small cell lung cancer; SRM, selected reaction monitoring; T1/2, elimination

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

A rapid and sensitive LC/ESI–MS/MS method for quantitative analysis of docetaxel in human plasma and its application to a pharmacokinetic study

Keywords: LLOQ، حد پایین تر از مقدار سنجی; LC/MS/MS, liquid chromatography/tandem mass spectrometry; LLOQ, lower limit of quantification; MRM, multiple reaction monitoringDocetaxel; LC/ESI–MS/MS; Rapid and sensitive analysis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmacokinetics of protocatechuic acid in mouse and its quantification in human plasma using LC–tandem mass spectrometry

Keywords: LLOQ، حد پایین تر از مقدار سنجی; PCA, protocatechuic acid; NHBC, 3-nitro-4-hydroxybenzoic acid; BRB, black raspberry; ACN, acetonitrile; FA, Formic acid; QC, quality control; LLOQ, lower limit of quantification; HPLC, high performance liquid chromatography; LC–MS, liquid chromatography–m

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Therapeutic chaperone effect of N-Octyl 4-Epi-β-valienamine on murine GM1-gangliosidosis

Keywords: LLOQ، حد پایین تر از مقدار سنجی; β-gal, β-galactosidase; NOEV, N-octyl 4-epi-β-valienamine; DGJ, 1-deoxygalactonojirimycin; WT, wild type; KO, knockout; Tg, transgenic; LC, liquid chromatography; MS/MS, tandem mass spectrometry; LLOQ, lower limit of quantification; GOT, glutamic-oxalacet

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Direct measurement of free estradiol in human serum by equilibrium dialysis–liquid chromatography–tandem mass spectrometry and reference intervals of free estradiol in women

Keywords: LLOQ، حد پایین تر از مقدار سنجی; ED, equilibrium dialysis; LC, liquid chromatography; MS/MS, tandem mass spectrometry; MRM, multiple reaction monitoring; LLOQ, lower limit of quantification; ULOQ, upper limit of quantification; SHBG, sex-hormone binding globulinEquilibrium dialysis; Free

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Development and full validation of an UPLC-MS/MS method for the determination of an anti-allergic indolinone derivative in rat plasma, and application to a preliminary pharmacokinetic study

Keywords: LLOQ، حد پایین تر از مقدار سنجی; CV, coefficient of variation; UPLC-MS/MS, Ultra performance liquid chromatography with tandem mass spectrometric detection; LLOQ, lower limit of quantification; ULOQ, upper limit of quantification; RE, relative error; ca. (circa), about; Cal, calibrator;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Validation of a gyrolab™ assay for quantification of rituximab in human serum

Keywords: LLOQ، حد پایین تر از مقدار سنجی; PK, pharmacokinetics; ELISA, enzyme-linked immunosorbent assay; CD, compact disk; PBS, phosphate buffered saline; HABA, 4′-hydroxyazobenzene-2-carboxylic acid; QC, quality control; LLOQ, lower limit of quantification; ULOQ, upper limit of quantification;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Determination of reboxetine in rat brain microdialysates and plasma samples using liquid chromatography coupled to fluorescence detection

Keywords: LLOQ، حد پایین تر از مقدار سنجی; ACN, acetonitrile; BBB, blood–brain barrier; CNS, central nervous system; ECF, extracellular fluid; FMOC-Cl, 9-fluorenylmethyl chloroformate; i.p., intraperitoneal; LC, liquid chromatography; LLOQ, lower limit of quantification; LOD, limit of detection; N

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Liquid chromatography–tandem mass spectrometric assay for the PARP-1 inhibitor olaparib in combination with the nitrogen mustard melphalan in human plasma

Keywords: LLOQ، حد پایین تر از مقدار سنجی; BRCA, BReast CAncer gene; HESI, heated electrospray ionization; LLOQ, lower limit of quantification; PARP, poly(ADP-ribose) polymerase; SRM, selected reaction monitoring; QC, quality controlOlaparib; Melphalan; PARP inhibitor; LC–MS/MS; Human plasma

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Quantitative determination of methylnaltrexone in human serum using liquid chromatography–tandem mass spectrometry

Keywords: LLOQ، حد پایین تر از مقدار سنجی; LC–MS/MS, liquid chromatography–tandem mass spectrometry; LLOQ, lower limit of quantification; MNTX, methylnaltrexone; MRM, multiple reaction monitoringMethylnaltrexone; Naltrexone; LC–MS/MS; Serum; Quantification

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Rapid simultaneous analysis of cyclooxygenase, lipoxygenase and cytochrome P-450 metabolites of arachidonic and linoleic acids using high performance liquid chromatography/mass spectrometry in tandem mode

Keywords: LLOQ، حد پایین تر از مقدار سنجی; AA, arachidonic acid; COX, cyclooxygenase; CYP, cytochrome P450; DHET, dihydroxyeicosatrienoic acid; EET, epoxyeicosatrienoic acid; HETE, hydroxyeicosatrienoic acid; 13-HODE, 13-hydroxyoctadecadienoic acid; LLOQ, lower limit of quantification; LOD, limit

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

LC–MS/MS method for the simultaneous determination of clarithromycin, rifampicin and their main metabolites in horse plasma, epithelial lining fluid and broncho-alveolar cells

Keywords: LLOQ، حد پایین تر از مقدار سنجی; BAC, broncho-alveolar cells; BAL, broncho-alveolar lavage; CL, Aclarithromycin; DAc-RIF, 25-O-desacetylrifampicin; ELF, epithelial lining fluid; LC–MS/MS, liquid chromatography tandem mass spectrometry; LLOQ, lower limit of quantification; MRM, multiple r

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

LC–ESI-MS/MS method for the quantification of entecavir in human plasma and its application to bioequivalence study

Keywords: LLOQ، حد پایین تر از مقدار سنجی; LC–ESI-MS/MS, liquid chromatography–electro spray ionization-tandem mass spectrometry; MRM, multiple reaction monitoring; EV, entecavir; LM, lamivudine; LLOQ, lower limit of quantification; LOQ, limit of quantification; LQC, low quality control; MQC, medi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Quantification of intracellular and extracellular prostanoids stimulated by A23187 by liquid chromatography/electrospray ionization tandem mass spectrometry

Keywords: LLOQ، حد پایین تر از مقدار سنجی; COX, cyclooxygenase; IS, internal standard; LC/MS/MS, liquid chromatography/tandem mass spectrometry; LLOQ, lower limit of quantification; MRM, multiple reaction monitoring; PG, prostaglandin; TX, thromboxaneProstanoid; LC/MS/MS; Intracellular measurement

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Validation of immunoassay for protein biomarkers: Bioanalytical study plan implementation to support pre-clinical and clinical studies

Keywords: LLOQ، حد پایین تر از مقدار سنجی; AAPS, American association of pharmaceutical scientists; ACC, accuracy; STD, calibration standard; LLOQ, lower limit of quantification; MRD, minimum required dilution; CV, precision; QC, quality control; ULOQ, upper limit of quantificationImmunoassay; End

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Rapid quantification of mirtazapine and desmethyl mirtazapine in human plasma by LC–ESI-MS/MS: Application to a bioequivalence study

Keywords: LLOQ، حد پایین تر از مقدار سنجی; CS, calibration standard; CID, collision induced dissociation; DMRT, desmethyl mirtazapine; ESI, electrospray ionization; HQC, high quality control; IS, internal standard; LQC, low quality control; LLOQ, lower limit of quantification; LLE, liquid–liquid e

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Efficacy of the Protease Inhibitor BI 201335, Polymerase Inhibitor BI 207127, and Ribavirin in Patients With Chronic HCV Infection

Keywords: LLOQ، حد پایین تر از مقدار سنجی; Drug; Clinical Trial; Direct-Acting Antivirals; Peginterferon-FreeAE, adverse event; DAA, direct-acting antiviral agent; GT, genotype; LLOD, lower limit of detection; LLOQ, lower limit of quantification; NI, nucleoside polymerase inhibitor; NNI, non-nucle

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents

Keywords: LLOQ، حد پایین تر از مقدار سنجی; CAR, conditioned avoidance response; DOI, (±)-2,5-Dimethoxy-4-iodoamphetamine-HCl; HPLC, high performance liquid chromatography; LC, liquid chromatography; LLOQ, lower limit of quantification; MS, mass spectrometry; NMDA, N-methyl-d-aspartate; PCP, phency

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Quantification of nortriptyline in plasma by HPLC and fluorescence detection

Keywords: LLOQ، حد پایین تر از مقدار سنجی; Fmoc-Cl, 9H-fluoren-9-ylmethyl chloroformate; LOD, limit of detection; LLOQ, lower limit of quantification; NT, nortriptyline; RSD, relative standard deviationDerivatization; Fmoc chloride; Nortriptyline; HPLC

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Liquid chromatography–tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis

Keywords: LLOQ، حد پایین تر از مقدار سنجی; CID, collision induced dissociation; LLOQ, lower limit of quantification; SRM, selected reaction monitoring; QC, quality controlClobetasol propionate; Clobetasone butyrate; Topical corticosteroid; LC–MS/MS; Human serum; Atopic dermatitis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

An efficient HPLC method for the quantitative determination of atazanavir in human plasma suitable for bioequivalence and pharmacokinetic studies in healthy human subjects

Keywords: LLOQ، حد پایین تر از مقدار سنجی; ATV, atazanavir; PI, protease inhibitor; ARVs, antiretrovirals; DIAZ, diazepam; IS, internal standard; QC, quality control; LLOQ, lower limit of quantification; % RSD, percentage relative standard deviation; % RE, percentage relative errorHPLC-UV; Atazana

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

ESI-MS/MS quantification of 7α-hydroxy-4-cholesten-3-one facilitates rapid, convenient diagnostic testing for cerebrotendinous xanthomatosis

Keywords: LLOQ، حد پایین تر از مقدار سنجی; CTX, cerebrotendinous xanthomatosis; CA, cholic acid; CDCA, chenodeoxycholic acid; ESI, electrospray ionization; MS/MS, tandem mass spectrometry; GirP, Girard P; CID, collision induced dissociation; LLOQ, lower limit of quantification; SPE, solid-phase ex

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Simultaneous measurement of amiodarone and desethylamiodarone in human plasma and serum by stable isotope dilution liquid chromatography–tandem mass spectrometry assay

Keywords: LLOQ، حد پایین تر از مقدار سنجی; LC–MS/MS, liquid chromatography–tandem mass spectrometry; LOD, limit of detection; LLOQ, lower limit of quantification; PBS, phosphate buffered saline; SPE, solid phase extractionAmiodarone; Desethylamiodarone; Drug monitoring; Liquid chromatography; Mass

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

HPLC determination of novel dithiolethione containing drugs and its application for in vivo studies in rats

Keywords: LLOQ، حد پایین تر از مقدار سنجی; ADTOH, 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione; ACN, acetonitrile; LLOQ, lower limit of quantification; TFA, trifluoroacetic acid; QC, quality controls; RE, relative error; RSD, relative standard deviationDithiolethione; Diclofenac; Valproic acid; Si

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Development and validation of a Sensitive bioanalytical method for the quantitative estimation of Pantoprazole in human plasma samples by LC–MS/MS: Application to bioequivalence study

Keywords: LLOQ، حد پایین تر از مقدار سنجی; LC–MS/MS, liquid chromatography–tandem mass spectrometry; MRM, multiple reaction monitoring; PS, pantoprazole sodium; PSD3, pantoprazole D3; PPIs, proton pump inhibitors; LLOQ, lower limit of quantification; LOQ, Limit of Quantification; LQC, Lower Qualit

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Quantification of lysophosphatidic acids in rat brain tissue by liquid chromatography–electrospray tandem mass spectrometry

Keywords: LLOQ، حد پایین تر از مقدار سنجی; BSA, bovine serum albumin; FWHM, full-width at half-maximum; IS, internal standard; LLOQ, lower limit of quantification; LPA, lysophosphatidic acid; LPC, lysophosphatidylcholine; QC, quality control; TEA, triethylamineLysophosphatidic acid (LPA); Lysophos

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis of the flavonoid 3′,4′,5′-trimethoxyflavonol and its determination in plasma and tissues of mice by HPLC with fluorescence detection

Keywords: LLOQ، حد پایین تر از مقدار سنجی; TMFol, 3′,4′,5′-trimethoxyflavonol; HPLC, high performance liquid chromatography; PMF, 3′,4′,5′,5,7-pentamethoxyflavone; DMSO, dimethyl sulfoxide; LLOQ, lower limit of quantification; LoQC, low quality control sample; MeQC, medium quality control sample;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

A high-throughput test to detect C.E.R.A. doping in blood

Keywords: LLOQ، حد پایین تر از مقدار سنجی; C.E.R.A., continuous erythropoietin receptor activator; DIG, digoxigenin; ELISA, enzyme-linked immunosorbent assay; EPO, erythropoietin; ESA, erythropoiesis-stimulating agent; IEF, isoelectric focusing; LLOQ, lower limit of quantification; LLQC, lower lim

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

High-throughput quantification of a novel thiazolidinedione MCC-555 in rat plasma by ultra-fast liquid chromatography and its application in pharmacokinetic studies

Keywords: LLOQ، حد پایین تر از مقدار سنجی; UFLC, ultra-fast liquid chromatography; HPLC, high-performance liquid chromatography; LC-MS, liquid chromatography tandem mass spectrometry; LLOQ, lower limit of quantification; TZDs, thiazolidinediones; NIDDM, non-insulin-dependent diabetes mellitus; PPA

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

In vivo pharmacokinetics comparisons of icariin, emodin and psoralen from Gan-kang granules and extracts of Herba Epimedii, Nepal dock root, Ficus hirta yahl

Keywords: LLOQ، حد پایین تر از مقدار سنجی; GKG, Gan-kang granules; ICH, International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use; IS, internal standard; LLOQ, lower limit of quantification; QC, quality control; RE, relative deviation; RS

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Analytical validation of a highly sensitive microparticle-based immunoassay for the quantitation of IL-13 in human serum using the Erenna® immunoassay system

Keywords: LLOQ، حد پایین تر از مقدار سنجی; IL-13, Interleukin-13; PD, pharmacodynamic; AHR, airway hyperresponsiveness; BAL, bronchial lavage fluid; LoD, limit of detection; LLoQ, lower limit of quantification; ULoQ, upper limit of quantification; CV, coefficient of variance; SD, standard deviatio

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Simultaneous determination of multiple angiotensin type 1 receptor antagonists and its application to high-throughput pharmacokinetic study: Cassette dosing versus cassette analysis

Keywords: LLOQ، حد پایین تر از مقدار سنجی; AT1RAs, angiotensin type 1 receptor antagonists; LC–MS/MS, high performance liquid chromatography-electrospray tandem mass spectrometry; QC, quality control; LLOQ, lower limit of quantification; SRM; selective reaction monitoring; LLE, liquid–liquid extra

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Quantitative determination of trans-polydatin, a natural strong anti-oxidative compound, in rat plasma and cellular environment of a human colon adenocarcinoma cell line for pharmacokinetic studies

Keywords: LLOQ، حد پایین تر از مقدار سنجی; HPLC, high performance liquid chromatography; IS, internal standard; QC, quality control; LLOQ, lower limit of quantification; RE, relative error; RSD, relative standard deviation; CV, coefficient of variation; AE, absolute recovery; Caco-2, human colon a

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه