کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6287390 1615588 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of radiation-induced sensorineural hearing loss and radioprotection
ترجمه فارسی عنوان
مکانیسم کاهش شنوایی حسگر نورونی و حفاظت از رادیواکتیو ناشی از تابش اشعه
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
چکیده انگلیسی
Patients that receive radiotherapy are at risk of late sensorineural hearing loss when the inner ear is included within the radiation field. Preclinical and human temporal bone studies have shown that there is differential damage to cochlear structures depending on the amount of dose delivered to the inner ear. In vitro studies have suggested that reactive oxygen species (ROS) are the main initial actors in radiation-induced damage. The interaction of ROS with different cellular components can result in different apoptotic pathways. Therefore, approaches to radioprotection are mainly aimed to reduce ROS production through antioxidants. This review summarizes recent research in the field that can improve the understanding and boost preventive efforts of this adverse effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 312, June 2014, Pages 60-68
نویسندگان
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