کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8284727 | 1535585 | 2017 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional relevance of miRNAs in premature ageing
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کلمات کلیدی
DSBSASPMEFsshRNAhMSCsDDRmiRNAsHRRHDACssmall hairpin RNA - RNA کوچک موی سرROS - ROSsiRNA - siRNAsmall interference RNA - تداخل کوچک RNAHomologous recombination repair - تعمیر مجدد هومولوگAgeing - سالخوردهhuman mesenchymal stem cells - سلول های بنیادی مزانشیمی انسانیProgeroid syndromes - سندرم پروگروئیدdouble-strand breaks - شکست دو ردیفSenescence-associated secretory phenotype - فنوتیپ ترشحی مرتبط با سن زاییmouse embryonic fibroblast - موش فیبروبلاست جنینیhistone deacetylases - هیستون deacetylaseshistone acetyltransferases - هیستون استیل ترانسفرازDNA damage response - واکنش به آسیب DNA C-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی HATs - کلاهReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ageing is a complex biological process characterized by the progressive loss of biological fitness due to the accumulation of macromolecular and cellular damage that affects most living organisms. Moreover, ageing is an important risk factor for many pathologies, including cardiovascular diseases, neurological disorders, and cancer. However, the ageing rate can be modulated by genetic, nutritional, and pharmacological factors, highlighting the concept of “ageing plasticity”. Progeroid syndromes are a group of rare genetic diseases that resemble many characteristics of physiological ageing. Accordingly, studies on these diseases have been very useful for gaining mechanistic insights in ageing biology. In recent years, a great effort has been made in ageing research and several works have confirmed that geromiRs, the growing subgroup of miRNAs implicated in ageing, are able to modulate organismal lifespan. However, very little is still known about the impact of miRNA in premature ageing. In this review, we will address the functional relevance of this class of small non-coding RNAs in the regulation of the hallmarks of progeroid syndromes. In addition, we will discuss the potential strategies for managing progeria based on geromiR modulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 168, December 2017, Pages 10-19
Journal: Mechanisms of Ageing and Development - Volume 168, December 2017, Pages 10-19
نویسندگان
Xurde M. Caravia, David Roiz-Valle, Alba Morán-Álvarez, Carlos López-OtÃn,