Keywords: تعمیر مجدد هومولوگ; ALT; alternative lengthening of telomeres; CDK; cyclin-dependent kinase; DDR; DNA damage response; dNTP; deoxyriboNucleotide TriPhosphate; DPC; DNA-protein crosslink; DSB; double-strand break; FDA; Food and Drug Administration; HRR; homologous recombinati
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Keywords: تعمیر مجدد هومولوگ; LS; Lynch syndrome; CRC; colorectal cancer; HNPCC; hereditary non-polyposis colon cancer; MMR; mismatch repair; FAP; familial adenomatous polyposis; CFS; cancer family syndrome; MSI; microsatellite instability; IDL; insertion/deletion loop; MSH2; human mu
Keywords: تعمیر مجدد هومولوگ; PARP inhibitors; DNA repair; Homologous recombination repair; HRD; Homologous recombination deficiency; BRCA1; BRCA2; Ovarian cancer; Olaparib;
Keywords: تعمیر مجدد هومولوگ; DNA double strand breaks; Ionizing radiation; Homologous recombination repair; Alternative end-joining; Non-homologous end-joining; Chromosome translocations;
Keywords: تعمیر مجدد هومولوگ; 17-AAG; 17-(Allylamino)-17-demethoxygeldanamycin; 17-DMAG; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin; AKT; v-akt murine thymoma viral oncogene homolog; APC; antigen presenting cell; ATM; Ataxia telangiectasia mutated; ATR; Ataxia telangiectasia
The radiotherapy-sensitization effect of cantharidin: Mechanisms involving cell cycle regulation, enhanced DNA damage, and inhibited DNA damage repair
Keywords: تعمیر مجدد هومولوگ; Pancreatic cancer; Cantharidin; Cell cycle; DNA damage repair; Radiotherapy; PP2A; protein phosphatase 2A; MTT; methyl thiazolyl tetrazolium; DMSO; dimethyl sulfoxide; NER; nucleotide excision repair; BER; base excision repair; MMR; mismatch repair; DSB;
Irradiation by γ-rays reduces the level of H3S10 phosphorylation and weakens the G2 phase-dependent interaction between H3S10 phosphorylation and γH2AX
Keywords: تعمیر مجدد هومولوگ; Mass spectrometry; Histones H3 and H4; γH2AX; DNA damage; Embryonic stem cells; Epigenetics; FLIM; Fluorescence lifetime image microscopy; FRET; Förster resonance energy transfer; H3; histone H3; H4; histone H4; me1; monomethylated histones; me2; dimeth
Prolonged particulate chromate exposure does not inhibit homologous recombination repair in North Atlantic right whale (Eubalaena glacialis) lung cells
Keywords: تعمیر مجدد هومولوگ; Hexavalent chromium; Homologous recombination repair; Genomic instability; North Atlantic right whale lung fibroblasts; Rad51;
The impact of the IGF-1 system of cancer cells on radiation response - An in vitro study
Keywords: تعمیر مجدد هومولوگ; IGF-1R; insulin-like growth factor 1 receptor; SF; surviving fractions; IGF-1R/KR; kinase-deficient IGF-1R; Caco-2-KR4; IGF-1R/KR clone number 4; IRS-1; insulin receptor substrate 1; HRR; homologous recombination repair; NHEJ; non-homologous end joining;
Germline mutations in DNA repair genes predispose asbestos-exposed patients to malignant pleural mesothelioma
Keywords: تعمیر مجدد هومولوگ; Mesothelioma; Asbestos exposure; Germline mutation; DNA repair genes; Homologous recombination repair;
Original ArticlePoly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells
Keywords: تعمیر مجدد هومولوگ; Acute lymphoblastic leukemia; TCF3-HLF; Homologous recombination repair; PARP inhibitor;
Functional relevance of miRNAs in premature ageing
Keywords: تعمیر مجدد هومولوگ; CRP; C-reactive protein; DDR; DNA damage response; DSB; double-strand breaks; HATs; histone acetyltransferases; HDACs; histone deacetylases; hMSCs; human mesenchymal stem cells; HRR; homologous recombination repair; MEFs; mouse embryonic fibroblast; ROS;
MiroRNA-127-3p targets XRCC3 to enhance the chemosensitivity of esophageal cancer cells to a novel phenanthroline-dione derivative
Keywords: تعمیر مجدد هومولوگ; microRNA-127-3p; XRCC3; Homologous recombination repair; Chemosensitivity; Phenanthroline-dione derivative;
Cells redox environment modulates BRCA1 expression and DNA homologous recombination repair
Keywords: تعمیر مجدد هومولوگ; bp; base pairs; BRCA1; breast cancer type 1 susceptibility protein; CO3â¢â; carbonate; DETA; DETA NONOate; DSB; double strand break; EtBr; ethidium bromide; ETC; electron transport chain; FAD; flavin adenine dinucleotide; FADH; reduced flavin adenine d
Hydroxymethylation and its potential implication in DNA repair system: A review and future perspectives
Keywords: تعمیر مجدد هومولوگ; C; Cytosine; DNMT; DNA methyl transferase; BER; Base Excision Repair; NER; Nucleotide Excision Repair; TET; Ten Eleven Translocation protein; 5mC; 5methylcytosine; 5hmC; 5-hydroxymethylcytosine; 5fC; 5-formylcytosine; 5caC; 5-carboxylcytosine; ESC; Embryo
Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair
Keywords: تعمیر مجدد هومولوگ; Mre11-Rad50-Nbs1; CtIP; Allostery; Double strand break repair; Dynamics; Conformational change; AFM; atomic force microscopy; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; BRCT; BRCA1 C-terminus domain; DSB; DNA
DR-GAS: A database of functional genetic variants and their phosphorylation states in human DNA repair systems
Keywords: تعمیر مجدد هومولوگ; GAS; Haplotype; nsSNP; LD; Phosphorylation; BER; base excision repair; NER; nucleotide excision repair; MMR; mismatch repair; HRR; homologous recombination repair; NHEJ; non-homologous end joining; TLS; trans lesion synthesis; DDS; DNA damage signaling; H
Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells
Keywords: تعمیر مجدد هومولوگ; Linifanib (ABT-869); Veliparib (ABT-888); PARP inhibitor; DNA damage; Homologous recombination repair; Apoptosis; Head and Neck Squamous Cell Carcinoma;
Association between the XRCC3 T241M polymorphism and risk of cancer: Evidence from 157 case-control studies
Keywords: تعمیر مجدد هومولوگ; XRCC3; the X-ray repair cross-complementing group 3; OR; odds ratios; CIs; confidence intervals; BER; base excision repair; NER; nucleotide excision repair; DSBR; double-strand break repair; MMR; mismatch repair; HWE; Hardy-Weinberg equilibrium; HRR; ho
Ionizing radiation-induced gene expression changes in TP53 proficient and deficient glioblastoma cell lines
Keywords: تعمیر مجدد هومولوگ; GBM; glioblastoma; MT; mutated; WT; wild type; SAM; significance analysis of microarray; FDR; false discovery rate; qPCR; quantitative real-time PCR; SSBs; single-strand breaks; DSBs; double-strand breaks; HRR; homologous recombination repair; NHEJ; non-h
Cylindrospermopsin induced transcriptional responses in human hepatoma HepG2 cells
Keywords: تعمیر مجدد هومولوگ; AP-1; activator protein; BER; base excision repair; CDK; cyclin-dependant kinase; CDKI; cyclin-dependant kinase inhibitor; CYN; cylindrospermopsin; CYP450; cytochrome P450; DSB; DNA double-strand break; ER; endoplasmic reticulum; GST; glutathione S-transf
The type of mutations induced by carbon-ion-beam irradiation of the filamentous fungus Neurospora crassa
Keywords: تعمیر مجدد هومولوگ; Carbon-ion beam; Double-strand break; Heavy-ion beam; Homologous recombination repair; Neurospora crassa; Nonhomologous end-joining
The role of Deinococcus radiodurans RecFOR proteins in homologous recombination
Keywords: تعمیر مجدد هومولوگ; Deinococcus radiodurans; DNA repair; Homologous intermolecular recombination; Homologous recombination repair; RecFOR;
Homologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: Comparison with other hypoxia-activated prodrugs
Keywords: تعمیر مجدد هومولوگ; Hypoxia-activated prodrug; Homologous recombination repair; Redox cycling; CEN-209; Tirapazamine; TH-302
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography
Keywords: تعمیر مجدد هومولوگ; 53BP1; Tp53 binding protein 1; 9-1-1; RAD9-RAD1-HUS1 checkpoint clamp complex; a.a.; amino acid; ACF1; ATP-utilizing chromatin assembly and remodeling factor 1; ALC1; amplified in liver cancer 1; APLF/PALF; aprataxin and PNKP-like factor; Aprataxi
c-ABL tyrosine kinase stabilizes RAD51 chromatin association
Keywords: تعمیر مجدد هومولوگ; Homologous recombination repair; RAD51; BRCA2; ATM; c-ABL; Tyrosine phosphorylation;
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: Mechanistic insights
Keywords: تعمیر مجدد هومولوگ; DNA crosslinking; Mutagenesis; Crosslink repair; DNA replication forks; Chromosomal instability; Translesion synthesis; Homologous recombination repair
TopBP1 associates with NBS1 and is involved in homologous recombination repair
Keywords: تعمیر مجدد هومولوگ; TopBP1; NBS1; ATR; Homologous recombination repair
Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair
Keywords: تعمیر مجدد هومولوگ; amyotrophic lateral sclerosis; ataxia-telangiectasia-like disorder; Werner syndrome; xeroderma pigmentosum; nitric oxide synthase; superoxide dismutase; AfXPB; Archaeoglobus fulgidus XPB; AH; autoinhibitory helix; ALS; amyotrophic lateral sclerosis; ATL
Single-stranded oligonucleotide-mediated gene repair in mammalian cells has a mechanism distinct from homologous recombination repair
Keywords: تعمیر مجدد هومولوگ; Gene repair; Oligonucleotide; Double-stranded break; Homologous recombination repair
Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair
Keywords: تعمیر مجدد هومولوگ; Ubr2 ubiquitin ligase; N-end rule proteolytic pathway; Genome instability; Fragile sites; Homologous recombination repair; Mitomycin C sensitivity
Micronuclei in humans induced by exposure to low level of ionizing radiation: influence of polymorphisms in DNA repair genes
Keywords: تعمیر مجدد هومولوگ; CA; chromosomal aberrations; MN; micronuclei; BER; base excision repair; HRR; homologous recombination repair; SNPs; single nucleotide polymorphisms; NER; nucleotide excision repair; EPIC; European prospective investigation into cancer and nutrition; FFQ;
Ionizing radiation and genetic risks
Keywords: تعمیر مجدد هومولوگ; AS; Angelman syndrome; BEIR Committee; Biological Effects of Ionizing Radiation committee of the U.S. National Academy of Sciences; BFB; Breakage fusion bridge cycle; CMT1A; Charcot-Marie-Tooth disease type 1A; DGS/VCFS; Di George/Velocardiofacial syndrom