کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9909195 | 1548439 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Micronuclei in humans induced by exposure to low level of ionizing radiation: influence of polymorphisms in DNA repair genes
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کلمات کلیدی
HWBbinucleatedHRRSNPsNDIEPICBERFFQSSCPNER - DOWNS.D. - SD.Chromosomal aberrations - اختلالات کروموزومیstandard deviation - انحراف معیارionizing radiation - تابش یوننده یا پرتوهای یونیزانEuropean Prospective Investigation into Cancer and Nutrition - تحقیقات آینده اروپا در مورد سرطان و تغذیهnucleotide excision repair - تعمیر مجدد نوکلئوتیدیHomologous recombination repair - تعمیر مجدد هومولوگbase excision repair - تعمیر پایه پایهPCR-RFLP - روش PCR-RFLPmicronuclei - ریزهستک یا میکرونوکلئوس nuclear division index - شاخص تقسیم هسته ایfluorescence in situ hybridization - فلورسانس در هیبریداسیون در محلOccupational exposure - قرار گرفتن در معرض شغلیFish - ماهیfood frequency questionnaire - پرسشنامه فرکانس غذاSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیpolymerase chain reaction-restriction fragment length polymorphism - پلیمورفیسم طول قطعه واکنش زنجیره پلیمرازGenetic polymorphisms - پلیمورفیسم ژنتیکیSingle strand conformation polymorphism - پلیمورفیسم یکپارچگی رشتهDNA repair genes - ژن های ترمیم DNA
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Understanding the risks deriving from protracted exposure to low doses of ionizing radiation has remarkable societal importance in view of the large number of work settings in which sources of IR are encountered. To address this question, we studied the frequency of micronuclei (MN), which is an indicator of DNA damage, in a population exposed to low levels of ionizing radiation and in matched controls. In both exposed population and controls, the possible influence of single nucleotide polymorphisms in XRCC1, XRCC3 and XPD genes on the frequency of micronuclei was also evaluated. We also considered the effects of confounding factors, like smoking status, age and gender. The results indicated that MN frequency was significantly higher in the exposed workers than in the controls [8.62 ± 2.80 versus 6.86 ± 2.65; P = 0.019]. Radiological workers with variant alleles for XRCC1 or XRCC3 polymorphisms or wild-type alleles for XPD exon 23 or 10 polymorphisms showed a significantly higher MN frequency than controls with the same genotypes. Smoking status did not affect micronuclei frequency either in exposed workers or controls, while age was associated with increased MN frequency in the exposed only. In the combined population, gender but not age exerted an influence on the yield of MN, being higher in females than in males. Even though there is a limitation in this study due to the small number of subjects, these results suggest that even exposures to low level of ionizing radiation could have genotoxic effects and that XRCC3, XRCC1 and XPD polymorphisms might contribute to the increased genetic damage in susceptible individuals occupationally exposed to chronic low levels of ionizing radiation. For a clear conclusion on the induction of DNA damage caused by protracted exposure to low doses of ionizing radiation and the possible influence of genetic polymorphism in DNA repair genes larger studies are needed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 570, Issue 1, 15 February 2005, Pages 105-117
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 570, Issue 1, 15 February 2005, Pages 105-117
نویسندگان
Sabrina Angelini, Rajiv Kumar, Fabio Carbone, Francesca Maffei, Giorgio Cantelli Forti, Francesco Saverio Violante, Vittorio Lodi, Stefania Curti, Kari Hemminki, Patrizia Hrelia,