کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8536792 | 1560917 | 2018 | 58 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Targeting the replication stress response in cancer
ترجمه فارسی عنوان
هدف قرار دادن پاسخ تنش تکثیر در سرطان
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
ALTFDADNA-protein crosslinkDPCdNTPDDRHRRDSBCDKdeoxyribonucleotide triphosphate - تری فسفات دز اکسید ریبونوکلئوتیدHomologous recombination repair - تعمیر مجدد هومولوگFood and Drug Administration - سازمان غذا و داروdouble-strand break - شکست دو ردیفAlternative lengthening of telomeres - طولانی شدن جایگزین تلومرهاHydroxyurea - هیدروکسی اورهDNA damage response - واکنش به آسیب DNA cyclin-dependent kinase - کییناز وابسته به سیکلین
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
چکیده انگلیسی
Many conventional chemotherapies used in cancer treatment exert their effect by inflicting DNA damage. Highly proliferative tissues, as well as tumour cells, are particularly vulnerable to this damage resulting in unwanted toxicities. In contrast, a targeted therapeutic approach has the aim of specifically eliminating cancer cells but with a reduced effect on healthy tissue. New therapies have been developed that target the replication stress response (RSR), a branch of the broader DNA damage response that specifically deals with interferences of the normal DNA replication program. Different pharmaceutical companies have developed inhibitors of the RSR kinases ATR, CHK1 and WEE1, which are currently at different phases of clinical development. Here, we review how the RSR works at the molecular level, what is the rationale for its targeting, and how we envisage its best use in the clinic, based on patient selection and combination therapies supported by in vitro and in vivo preclinical studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 188, August 2018, Pages 155-167
Journal: Pharmacology & Therapeutics - Volume 188, August 2018, Pages 155-167
نویسندگان
Josep V. Forment, Mark J. O'Connor,