Keywords: شکست دو ردیف; Homologous recombination; Double-strand break; Genomic integrity;
مقالات ISI شکست دو ردیف (ترجمه نشده)
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Keywords: شکست دو ردیف; 53BP1; p53 binding protein 1; BRCA1; breast cancer protein 1; DDB1; DNA damage-binding protein 1; DSB; double-strand break; H3; histone 3; H3K9me; methylation of histone 3 lysine 9; HR; homologous recombination; INM; inner nuclear membrane; LBR; lamin B r
Keywords: شکست دو ردیف; Primary immunodeficiency; malignancy; tumor predisposition; immune surveillance; pre-existing condition; ALL; Acute lymphoblastic leukemia; ALPS; Autoimmune lymphoproliferative syndrome; AT; Ataxia teleangiectasia; CHH; Cartilage-hair hypoplasia; CID; Com
Keywords: شکست دو ردیف; Breeding methods; Chrysanthemum morifolium; CRISPR/Cas9; Genome editing; Ornamental plants; Transgenic technologies; 4CL; 4-coumarate:coenzyme A ligase; C3H; coumarate 3-hydroxylase; C4H; cinnamate 4-hydroxylase; CCD4; carotenoid cleavage dioxygenase 4; C
Keywords: شکست دو ردیف; ALT; alternative lengthening of telomeres; CDK; cyclin-dependent kinase; DDR; DNA damage response; dNTP; deoxyriboNucleotide TriPhosphate; DPC; DNA-protein crosslink; DSB; double-strand break; FDA; Food and Drug Administration; HRR; homologous recombinati
Keywords: شکست دو ردیف; ac; acetylation; BET; bromodomain and extra terminal family proteins; BMP7; bone morphogenic protein 7; BRD4; bromodomain-containing protein 4; bp; base pairs; CKD; chronic kidney disease; CTGF; connective tissue growth factor; DDR; DNA damage response; D
Keywords: شکست دو ردیف; AZT; azidothymidine; DSB; double-strand break; dsDNA; double-strand DNA; gDNA; gapped DNA; HR; homologous recombination; HU; hydroxyurea; indel; insertion/deletion; IR; inverted repeats; QP; quasipalindrome; QPM; quasipalindrome-associated mutagenesis; SC
Keywords: شکست دو ردیف; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AT; ataxia telangiectasia; BER; base excision repair; BFB; breakage-fusion-bridge; BMDCs; bone marrow-derived cells; BS; Bloom syndrome; CIN; chromosome instability; CNS; central nervous syste
Keywords: شکست دو ردیف; MN; micronuclei; MNE; micronucleated erythrocytes; MNEF; micronucleated erythrocytes frequency; SSB; single-strand break; DSB; double-strand break; TE; total erythrocytes; BM; body mass; ML; maximum longevity; NHEJ; non-homologous end joining; HR; homolog
Keywords: شکست دو ردیف; DSB; double-strand break; HR; homologous recombination; HDR; homology-directed repair; BIR; break-induced replication; NHEJ; nonhomologous end-joining; Alt-NHEJ; alternative-NHEJ; MMEJ; microhomology-mediated end-joining; ssDNA; single-stranded DNA; Doubl
Keywords: شکست دو ردیف; Double-strand break; Nucleosome; Chromatin; Cell cycle; Chromatin dynamics;
Keywords: شکست دو ردیف; Severe combined immunodeficiency; radiation sensitivity; hematopoietic cell transplantation; nonhomologous end joining; DNA repair; ART-SCID; Artemis-deficient severe combined immunodeficiency; ATG; Antithymocyte globulin; DNA-PKcs; DNA-dependent protein
Keywords: شکست دو ردیف; DIQ; 1,5-dihydroxyisoquinoline; 4-AN; 4-amino-1,8-naphthalimide; 6,4PPs; 6,4-photoproducts; 8-oxodG; 8-oxo-2â²-deoxyguanosine; OGG1; 8-oxoguanine glycosylase 1; APE1; AP-endonuclease; ATM; ataxia telangiectasia-mutated gene; BER; base excision repair; BR
Keywords: شکست دو ردیف; Non-homologous end joining; Ku; Double-strand break; APLF; WRN;
Keywords: شکست دو ردیف; Alt-EJ; alternative end joining; APLF; aprataxin and polynucleotide kinase/phosphatase-like factor; ATM; ataxia-telangiectasia mutated; ATR; ATM-, Rad3-related; APTX; aprataxin; β-Casp; metallo-β-lactamase-associated CPSF Artemis SNM1 PSO2; BER; base ex
Keywords: شکست دو ردیف; 8-oxoG; 7,8-dihydro-8-oxoguanine; AECs; airway epithelial cells; AHR; airway hyperresponsiveness; APE1; AP-endonuclease 1; AP sites; apurinic/apyrimidinic site; BER; base excision repair; BALF; bronchoalveolar lavage fluid; CA; comet assay; DSB; double-st
The Implications of CRISPR-Cas9 Genome Editing for IR
Keywords: شکست دو ردیف; CRISPR; Clustered Regularly Interspaced Short Palindromic Repeats; DSB; double-strand break; HDR; homology-directed repair; HR; homologous recombination; NHEJ; nonhomologous end-joining; PAM; protospacer-adjacent motif; sgRNA; single guide RNA;
In vivo gene correction with targeted sequence substitution through microhomology-mediated end joining
Keywords: شکست دو ردیف; In vivo gene correction; Microhomology-mediated end-joining (MMEJ); Targeted sequence substitution (TSS); Hereditary tyrosinemia; Homology-directed repair (HDR); HDR; Homology-directed repair; NHEJ; Non-homologous end-joining; MMEJ; Microhomology-mediate
Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors
Keywords: شکست دو ردیف; 5-FU; 5-fluouracil; CRC; colorectal cancer; DSB; double-strand break; FBS; fetal bovine serum; ICL; interstrand-crosslinking; MMC; mitomycin C; MSI; microsatellite instability; NTC; non-transfected cells; PBS; phosphate buffered saline; pol; polymerase; R
Saccharomyces cerevisiae Mhr1 can bind Xho I-induced mitochondrial DNA double-strand breaks in vivo
Keywords: شکست دو ردیف; mtDNA; mitochondrial DNA; DSB; double-strand break; oxidative phosphorylation; OXPHOS; nuclear DNA; nDNA; reactive oxygen species; ROS; homologous recombination; HR; classical non-homologous end joining; C-NHEJ; yeast Ku80; Yku80; Mhr1; mitochondrial homo
The radiotherapy-sensitization effect of cantharidin: Mechanisms involving cell cycle regulation, enhanced DNA damage, and inhibited DNA damage repair
Keywords: شکست دو ردیف; Pancreatic cancer; Cantharidin; Cell cycle; DNA damage repair; Radiotherapy; PP2A; protein phosphatase 2A; MTT; methyl thiazolyl tetrazolium; DMSO; dimethyl sulfoxide; NER; nucleotide excision repair; BER; base excision repair; MMR; mismatch repair; DSB;
Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response
Keywords: شکست دو ردیف; APC/C; anaphase-promoting complex or cyclosome; ATM; ataxia-telangiectasia mutated protein; ATR; ataxia-telangiectasia- and rad3-related protein; CDC20; cell division cycle protein 20; CDK; cyclin-dependent kinase; CHK1; checkpoint kinase 1; CHK2; checkpo
SMARCAD1 Haploinsufficiency Underlies Huriez Syndrome and Associated Skin Cancer Susceptibility
Keywords: شکست دو ردیف; CSCC; cutaneous squamous cell carcinoma; DSB; double-strand break;
GIT2-A keystone in ageing and age-related disease
Keywords: شکست دو ردیف; AD; Alzheimer's disease; ArfGAP; ADP-ribosylation factor GTPase-activating proteins; AT; adipose tissue; ATM; Ataxia Telangiectasia Mutated; ATP; adenosine tri-phosphate; BRCA1; breast cancer type 1 susceptibility protein; CNS; central nervous system; D
DNA structural basis for fragility at peak III of BCL2 major breakpoint region associated with t(14;18) translocation
Keywords: شکست دو ردیف; Chromosomal translocation; Double-strand break; Non-B DNA structure; Cruciform DNA; Follicular lymphoma; Genomic instability;
Staphylococcus aureus Triggers Induction of miR-15B-5P to Diminish DNA Repair and Deregulate Inflammatory Response in Diabetic Foot Ulcers
Keywords: شکست دو ردیف; CFU; colony-forming unit; DFU; diabetic foot ulcer; DSB; double-strand break; FFPE; formalin-fixed paraffin-embedded; FS; foot skin; IPA; Ingenuity Pathway Analysis; miR; microRNA; MRSA; methicillin-resistant Staphylococcus aureus; qPCR; quantitative PCR;
R-loops cause genomic instability in T helper lymphocytes from patients with Wiskott-Aldrich syndrome
Keywords: شکست دو ردیف; Primary immunodeficiency; Wiskott-Aldrich syndrome; X-linked thrombocytopenia; TH1/TH2 differentiation; R-loops; DNA damage; genomic instability; ChIP; Chromatin immunoprecipitation; DDR; DNA damage response; DRB; 5,6-Dichlorobenzimidazole-1-β-D-ribofura
Zinc finger nuclease technology: A stable tool for high efficiency transformation in bloodstream form T. brucei
Keywords: شکست دو ردیف; HA; haemagglutinin; UTR; untranslated region; ZFN; zinc finger nuclease(s); Trypanosoma brucei; zinc finger nuclease; double-strand break; homologous recombination; transfection efficiency;
Genome-scale CRISPR pooled screens
Keywords: شکست دو ردیف; Genome engineering; Genetic screens; CRISPR; Cas9; Noncoding; Cancer; RNAi; RNA interference; CRISPR; clustered regularly interspaced short palindromic repeats; sgRNA; single-guide RNA; DSB; double-strand break; NHEJ; non-homologous end-joining; PCR; poly
In vivo imaging of DNA double-strand break induced telomere mobility during alternative lengthening of telomeres
Keywords: شکست دو ردیف; ALT; alternative lengthening of telomeres; HR; homologous recombination; DSB; double-strand break; MSD; mean square displacement; ER; modified estrogen receptor domain; DD; destabilization domain; 4-OHT; 4-hydroxytamoxifen; ALT; Live cell imaging; Confoca
Antioxidants Taken Orally prior to Diagnostic Radiation Exposure Can Prevent DNA Injury
Keywords: شکست دو ردیف; DSB; double-strand break; FCS; fetal calf serum; IQR; interquartile range; NAC; N-acetylcysteine; PBMC; peripheral blood mononuclear cell; PBS; phosphate-buffered saline; 99mTc MDP; technetium-99m methylene diphosphonate;
PerspectiveCanonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability
Keywords: شکست دو ردیف; HR; homologous recombination; DSB; double-strand break; NER; nucleotide excision repair; FA; Fanconi Anemia; ssDNA; single-stranded DNA; AQR; Aquarius; TC; transcription-coupled; ATM; ataxia-telangiectasia mutated; Genome Instability; R-loops; DNA repair;
A two-plasmid inducible CRISPR/Cas9 genome editing tool for Clostridium acetobutylicum
Keywords: شکست دو ردیف; aTc; anhydrotetracycline; CRISPR; Clustered regularly interspaced short palindromic repeats; Cas; CRISPR-associated proteins; Cas9n; Cas9 nickase; DSB; Double-strand break; gDNA; genomic DNA; gRNA; guide RNA; HR; Homologous recombination; NHEJ; Non-homolo
Genome instabilities arising from ribonucleotides in DNA
Keywords: شکست دو ردیف; AGS; Aicardi Goutieres Syndrome; DSB; double-strand break; HR; homologous recombination; Top1; topoisomerase 1; LOH; loss of heterozygosity; ncRNA; non-coding RNA; RER; ribonucleotide excision repair; dNTP; deoxynucleotide triphosphate; rNTP; ribonucleoti
Measurement of DNA damage in peripheral blood by the γ-H2AX assay as predictor of colorectal cancer risk
Keywords: شکست دو ردیف; DSBs; DNA double-strand breaks; PBLs; peripheral blood lymphocytes; CRC; colorectal cancer; IR; ionizing radiation; ORs; odds ratios; BMI; body mass index; HR; homologous recombination; NHEJ; non-homologous end joining; Gamma H2AX; Colorectal cancer risk;
Generation of chromosomal translocations that lead to conditional fusion protein expression using CRISPR-Cas9 and homology-directed repair
Keywords: شکست دو ردیف; Double-strand break; HDR; Chromosomal translocation; CRISPR-Cas9; EWSR1-WT1;
The Top1 paradox: Friend and foe of the eukaryotic genome
Keywords: شکست دو ردیف; Top1; topoisomerase I; DSB; double-strand break; RNAP; RNA polymerase; GCR; gross chromosomal rearrangement; CPT; camptothecin; G4; guanine quadruplex; TNR; trinucleotide repeat; CSR; class-switch recombination; AID; activation-induced cytosine deaminase;
CtIP/Ctp1/Sae2, molecular form fit for function
Keywords: شکست دو ردیف; MRN; Mre11-Rad50-Nbs1; HR; homologous recombination; THDD; tetrameric helical dimer of dimers; DSB; double-strand break; IR; ionizing radiation; NHEJ; non-homologous DNA end joining; MMEJ; microhomology-mediated end joining; IDR; intrinsically disordered
Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care
Keywords: شکست دو ردیف; G4; G-quadruplex; DSB; double-strand break; CFS; common fragile site; ERFS; early replicating fragile site; DRIP; DNA:RNA hybrid immunoprecipitation; SSB; single-strand break; NER; nucleotide excision repair; TC-NER; transcription-coupled nucleotide excis
Genetic variants of the DNA repair genes from Exome Aggregation Consortium (EXAC) database: significance in cancer
Keywords: شکست دو ردیف; AP; Apurinic/Apyrimidinic; BER; Base excision repair; dbSNP; Single Nucleotide Polymorphism database; DNA; Deoxyribonucleic acid; DSB; Double-strand break; ExAC; Exome Aggregation Consortium; FA; ;Fanconi Anemia; GGR; Global Genomic Repair; GWAS; Genome W
Exploring the potential of genome editing CRISPR-Cas9 technology
Keywords: شکست دو ردیف; Cas; CRISPR-associated proteins; cccDNA; covalently closed circular DNA; CCR5; C-C chemokine receptor type 5; CHO; Chinese hamster ovary; CRISPRs; clustered regularly interspaced short palindromic repeats; CRISPRa; CRISPR activation; CRISPRi; CRISPR inter
Original articleDecreased PLK1 expression denotes therapy resistance and unfavourable disease-free survival in rectal cancer patients receiving neoadjuvant chemoradiotherapy
Keywords: شکست دو ردیف; CRT; chemoradiotherapy; DSB; double-strand break; FFPE; formalin-fixed paraffin-embedded; MRI; magnetic resonance imaging; MTA; microtubule-targeting agent; Plk1; Polo-like kinase 1; TMA; tissue microarray; Chemoradiotherapy; Polo-like kinase 1; Predictiv
CRISPR/Cas9: A powerful tool for crop genome editing
Keywords: شکست دو ردیف; CRISPR/Cas9; Double-strand break; Genome editing; TALENs; ZFNs
Original ArticleCompromized DNA repair as a basis for identification of cancer radiotherapy patients with extreme radiosensitivity
Keywords: شکست دو ردیف; Radiation therapy; Radiosensitivity; Predictive assays; DNA repair; γ-H2AX; Statistical criteria; RT; radiation therapy; RS; radiosensitivity; γ-H2AX; phosphorylated histone H2AX; 53BP1; p53 binding protein 1; DSB; double-strand break; PBL; peripheral b
Yap1 and Skn7 genetically interact with Rad51 in response to oxidative stress and DNA double-strand break in Saccharomyces cerevisiae
Keywords: شکست دو ردیف; DSB; double-strand break; SSB; single-strand break; ROS; reactive oxygen species; HR; homologous recombination; NHEJ; non-homologous end joining; BER; base excision repair; NER; nucleotide excision repair; PQ; paraquat; PHL; phleomycin; HU; hydroxyurea; M
RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity
Keywords: شکست دو ردیف; HR; homologous recombination; CFA; colony forming assay; NT; N-terminus; ssDNA; single-stranded DNA; ICL; interstrand crosslink; DSB; double-strand break; MEF; mouse embryo fibroblasts; MMC; mitomycin C; MMS; methyl methanesulfonate; PTM; post-translation
Application of the microfluidic-assisted replication track analysis to measure DNA repair in human and mouse cells
Keywords: شکست دو ردیف; BER; base excision repair; BrdU; bromo-deoxyuridine; CldU; chloro-deoxyuridine; CPD; cyclopyrimidine dimer; DSB; double-strand break; EdU; ethynyl-deoxyuridine; IdU; iodo-deoxyuridine; maRTA; microfluidic-assisted replication track analysis; MMC; mitomyci
DNA repair by RNA: Templated, or not templated, that is the question
Keywords: شکست دو ردیف; DSB; double-strand break; HR; homologous recombination; NHEJ; non-homologous end joining; cDNA; complementary DNA; RT; reverse transcriptase; Ty; transposon-yeast; LINE-1; Long Intersperse Element-1; dsDNA; double-stranded DNA; AGS; Aicardi-Goutières syn
House dust mite-induced asthma causes oxidative damage and DNA double-strand breaks in the lungs
Keywords: شکست دو ردیف; House dust mite; asthma; oxidative stress; DNA double-strand breaks; BEAS-2B; cell death; DNA repair; NU7441; AHR; Airway hyperresponsiveness; ATM; Ataxia-telangiectasia mutated; BAL; Bronchoalveolar lavage; CC10; Club cell 10Â kDa protein; DCFH-DA; 2,7-D
Targeting the replisome with transduced monoclonal antibodies triggers lethal DNA replication stress in cancer cells
Keywords: شکست دو ردیف; DDR; DNA damage response; DSB; double-strand break; CRISPR; clustered regularly interspaced short palindromic repeats; CSK; cytoskeletal; DTT; dithiothreitol; EdU; 5-ethynyl-2â²-deoxyuridine; EM-CCD; electron multiplying-charge coupled device; γ-H2AX; p