کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10157672 | 1666473 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Altered nuclear envelope structure and proteasome function of micronuclei
ترجمه فارسی عنوان
ساختار بسته بندی هسته ای تغییر یافته و عملکرد پروتئازوم میکرونوکلئر
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کلمات کلیدی
DSBH3K9meNaClDDB1LBRNPCINMp53 binding protein 153BP1NETs - NET هاGenome instability - بی ثباتی ژنومmicronuclei - ریزهستک یا میکرونوکلئوس Sodium chloride - سدیم کلریدUbiquitin proteasome system - سیستم پروتئازوم Ubiquitindouble-strand break - شکست دو ردیفInner nuclear membrane - غشای هسته داخلیNup - قدم زدنnuclear pore complex - مجتمع مخرب هسته ایHomologous recombination - نوترکیبی همولوگNucleoporin - نولولپورینHistone 3 - هیستون 3nuclear envelope - پاکت هسته ایBRCA1 - ژن BRCA1chromothripsis - کروماتریپسLamin B receptor - گیرنده Lamin BUPS - یو پی اس
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
Micronuclei are extra-nuclear bodies containing whole chromosomes that were not incorporated into the nucleus after cell division or damaged chromosome fragments. Even though the link between micronuclei and DNA damage is described for a long time, little is known about the functional organization of micronuclei and their contribution to tumorigenesis. We showed fusions between micronuclear membranes and lysosomes by electron microscopy and linked lysosome function to DNA damage levels in micronuclei. In addition, micronuclei drastically differ from primary nuclei in nuclear envelope composition, with a significant increase in the relative amount of nuclear envelope proteins LBR and emerin and a decrease in nuclear pore proteins. Strikingly, micronuclei lack active proteasomes, as the processing subunits and other factors of the ubiquitin proteasome system. Moreover, micronuclear chromatin shows a higher degree of compaction as compared to primary nuclei. The specific aberrations identified in micronuclei and the potential functional consequences of these defects may contribute to the role of micronuclei in catastrophic genomic rearrangements.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 371, Issue 2, 15 October 2018, Pages 353-363
Journal: Experimental Cell Research - Volume 371, Issue 2, 15 October 2018, Pages 353-363
نویسندگان
Kendra K. Maass, Fabian Rosing, Paolo Ronchi, Karolin V. Willmund, Frauke Devens, Michaela Hergt, Harald Herrmann, Peter Lichter, Aurélie Ernst,