دانلود مقالات ISI درباره 53Bp1 + ترجمه فارسی

ساختار بسته بندی هسته ای تغییر یافته و عملکرد پروتئازوم میکرونوکلئر

Altered nuclear envelope structure and proteasome function of micronuclei

Keywords: 53BP1; p53 binding protein 1; BRCA1; breast cancer protein 1; DDB1; DNA damage-binding protein 1; DSB; double-strand break; H3; histone 3; H3K9me; methylation of histone 3 lysine 9; HR; homologous recombination; INM; inner nuclear membrane; LBR; lamin B r

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

گلایکوزیدهای قلبی: از اهداف مولکولی تا مرگ سلولی ایمنولوژیک

Cardiac glycosides: From molecular targets to immunogenic cell death

Keywords: 53BP1; p53 binding protein 1; ACTH; adrenocorticotropic hormone; AIF; apoptosis-inducing factor; ATG5; autophagy-related 5; Bad; Bcl-2-associated death promoter; Bcl-2; B-cell lymphoma 2; Bcl-xL; B cell lymphoma extra-large; DSB; DNA double-strand break;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

تاثیر پیری سلولی در پیری پوست: مفهوم استراتژی های موزاییک و درمانی

The impact of cellular senescence in skin ageing: A notion of mosaic and therapeutic strategies

Keywords: 53BP1; 53-binding protein 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia mutated and Rad3-related; AURKA; aurora kinase A; CDK; cyclin-dependent kinase; Chk; checkpoint kinase; DDR; DNA damage response; DNA-SCARS; DNA segments with chro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

پاسخ کلیوی به استرس تکرار: پیامدهای زیست شناسی سرطان و درمان

ReviewCellular responses to replication stress: Implications in cancer biology and therapy

Keywords: 53BP1; tumor protein p53 binding protein 1; 9-1-1; RAD9-RAD1-HUS1; AND1; acidic nucleoplasmic DNA-binding protein 1; ATR; ataxia telangiectasia and Rad3 related; ATRIP; ATR interacting protein; BIR; break-induced replication; BLM (RECQL3); Bloom Syndrome;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

ارتباط بین واکنش های تابشی فیبروبلاست های کشت شده از بیماران فردی و خطر واکنش دیر پس از رادیوتراپی پستان

Correlation between the radiation responses of fibroblasts cultured from individual patients and the risk of late reaction after breast radiotherapy

Keywords: Breast cancer; Normal-tissue reaction; Individual radiosensitivity; Double-strand breaks; 53BP1; p53;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

پرتو یونیزاسیون آب مروارید: تحولات زیستی و مکانیکی اخیر و دیدگاه های پژوهشی آینده

Ionizing radiation induced cataracts: Recent biological and mechanistic developments and perspectives for future research

Keywords: A-bomb; atomic bomb; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; ATPase; adenosine triphosphatase; BER; base excision repair; Ca2+; calcium ions; CDKN1A; cyclin-dependent kinase inhibitor 1A; CHO; Chinese hamster ovary; COX-2; cycloox

دانلود رایگان متن کامل مقاله ISI 87 صفحه سال انتشار : 2016 سفارش ترجمه

تابش هدف ناشی از اثرات متقابل بین سلول های سرطانی مانند ساقه و غیر ساقه است

Target irradiation induced bystander effects between stem-like and non stem-like cancer cells

Keywords: Radiation-induced Bystander Effect (RIBE); Cancer stem-like cells (CSCs); 53BP1; c-PTIO; Proton microbeam;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA

Keywords: A-EJ; alternative end joing; APH; aphidicolin; BIR; break induced replication; BTRR; BLM helicase/topoisomerase IIIa (TOPOIIIa)/RMI1 and RMI2 cofactors; CFS; common fragile sites; Cis; cisplatin; DEB; diepoxybutane; DSBs; double strand breaks; DSEs; one e

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation

Keywords: 2-MeOE1/E2; 4-MeOE1/E2, methoxyestrogens; 2-OHE1/E2; 4-OHE1/E2, hydroxyestrogens; 53BP1; tumor protein p53 binding protein 1; DMBA; 7,12-dimethylbenz(a)anthracene; DSBs; DNA double-strand breaks; E1; estrone; E2; estradiol; E2-3G; E2-3-glucuronide; E2-17G

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Human sirtuin 3 (SIRT3) deacetylates histone H3 lysine 56 to promote nonhomologous end joining repair

Keywords: DNA repair; HDACs; 53BP1; BRCA1; Nuclear sirtuin; γH2AX;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

Integrating plant and animal biology for the search of novel DNA damage biomarkers

Keywords: ARP; actin related protein; ASK; Arabidopsis SPK1-like; At; Arabidopsis thaliana; ATAF; arabidopsis transcription activation factor; ATM; ataxia telangiectasia mutated; ATR; ATM and Rad3-related; ATRIP; ATR-interacting protein; BARD; BRCA1-associated RING

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

Biochemical and dynamic basis for combinatorial recognition of H3R2K9me2 by dual domains of UHRF1

Keywords: UHRF1; Tandem Tudor Domains; TTD-PHD; H3K9me2 recognition; 53BP1; Isothermal titration calorimetry; Molecular dynamics simulation; TTD; Tandom Tudor domain; PHD; Plant Homeodomain; TTD-PHD; Tandom Tudor domain- Plant Homeodomain; MD; Molecular dynamics; I

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

ReviewRegulation of repair pathway choice at two-ended DNA double-strand breaks

Keywords: DSB; NHEJ; HR; Two-ended DSB; BRCA1; 53BP1;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress

Keywords: MEFs; murine embryonic fibroblasts; Aphidicolin; ASCIZ; ATM; ATMIN; DYNLL1; 53BP1;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

PerspectiveDNA-Damage Response RNA-Binding Proteins (DDRBPs): Perspectives from a New Class of Proteins and Their RNA Targets

Keywords: 53BP1; tumor protein p53 binding protein 1; AGO2; Argonaute 2; ATM; ataxia telangiectasia mutated; BRCA1; breast cancer 1; DDR; DNA-damage response; DDRBP; DNA-damage response RNA-binding protein; DDSR1; DNA-damage-sensitive RNA 1; diRNA; double-strand-br

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome

Keywords: CPC; choroid plexus carcinoma; DSBs; double-strands breaks; LFS; Li-Fraumeni syndrome; mFISH; multicolour fluorescence in-situ hybridization; NHEJ; non-homologous end-joining; SEM; scanning electron microscopy; TEM; transmission electron microscopy; γH2A

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewTranscription and DNA Damage: Holding Hands or Crossing Swords?

Keywords: DSBs; DNA double-strand breaks; DDR; DNA damage response; MRN; MRE11-RAD50-NBS1; ATM; ataxia telangiectasia mutated; MDC1; mediator of DNA-damage checkpoint; 53BP1; p53-binding protein; NHEJ; non-homologous end joining; ncRNA; non-coding RNA; HR; homo

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

BRG1 and SMARCAL1 transcriptionally co-regulate DROSHA, DGCR8 and DICER in response to doxorubicin-induced DNA damage

Keywords: DNA repair; BRG1; SMARCAL1; miRNA biogenesis; Non-coding RNA; 53BP1; Double-strand break repair;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2017 سفارش ترجمه

Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice

Keywords: 53BP1; BRCA1; DSB-repair choice;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Original ArticleCompromized DNA repair as a basis for identification of cancer radiotherapy patients with extreme radiosensitivity

Keywords: Radiation therapy; Radiosensitivity; Predictive assays; DNA repair; γ-H2AX; Statistical criteria; RT; radiation therapy; RS; radiosensitivity; γ-H2AX; phosphorylated histone H2AX; 53BP1; p53 binding protein 1; DSB; double-strand break; PBL; peripheral b

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics

Keywords: 53BP1; tumor suppressor p53 binding protein 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related; Chk; checkpoint kinase; DSB; DNA double-strand break; DDR; DNA damage response; DNA-PKcs; DNA-dependent protein kinase, catalyt

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Cancer TARGETases: DSB repair as a pharmacological target

Keywords: DSB repair; Genome instability; Cancer; Kinases; Helicases; Nucleases; ALT; alternative telomere lengthening; AML; acute myeloid leukemia; A-T; ataxia-telangiectasia; ATM; ataxia-telangiectasia mutated; ATP; adenosine triphosphate; ATR; ataxia-tel

دانلود رایگان متن کامل مقاله ISI 110 صفحه سال انتشار : 2016 سفارش ترجمه

Emerging role of protein phosphatases changes the landscape of phospho-signaling in DNA damage response

Keywords: 53BP1; p53 binding protein 1; ATM; ataxia-telangiectasia mutated; ATR; ataxia telangiectasia and Rad3 related; BLM; blooms syndrome RecQ helicase-like, human homolog of SGS1; BRCA1; breast cancer 1, early onset; CDC; cell division cycle; CDK; cyclin depen

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Downregulation of PEA-15 reverses G1 arrest, and nuclear and chromatin changes of senescence phenotype via pErk1/2 translocation to nuclei

Keywords: HDF; human diploid fibroblasts; TPA; 12-O-tetradecanoylphorbol-13-acetate; SA-pErk1/2; senescence associated phospho-extracellular signal-regulated protein kinase 1/2; BrdU; 5-bromo-2′-deoxyuridine; PML; promyelocytic leukemia; 53BP1; p53-binding protei

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts

Keywords: 53BP1, p53-binding protein 1; AMPK, adenosine monophosphate-activated protein kinase; DSB, double-strand breaks; MEFs, mouse embryonic fibroblasts; NHEJ, nonhomologous end-joiningAMPKα; p21; 53BP1; DNA damage; Cell proliferation; Apoptosis

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

BLM protein mitigates formaldehyde-induced genomic instability

Keywords: 53BP1; p53 binding protein; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related; CGRP; calcitonin gene-related peptide; BLM; bloom protein; CHO; Chinese Hamster Ovary; DSB; double-strand break; DPC; DNA-protein crosslink; ATM;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Dental composite components induce DNA-damage and altered nuclear morphology in gingiva fibroblasts

Keywords: Dental composites; Monomers; Chromatin; Gingiva fibroblasts; DNA damage; Nuclear morphology; DNA double-strand breaks; γ-H2AX; 53BP1;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Common Genetic Variants in 53BP1 Associated with Nonsmall-cell Lung Cancer Risk in Han Chinese

Keywords: Lung cancer; Single nucleotide polymorphism; Disease susceptibility; 53BP1; TP53

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Novel roles of 1α,25(OH)2D3 on DNA repair provide new strategies for breast cancer treatment

Keywords: TNBC; triple negative breast cancers; BRCA1; breast cancer susceptibility gene 1; PARPi; poly(ADP-ribose) polymerase inhibitors; CTSL; cathepsin L; DSBs; double strand breaks; HR; homologous recombination; NHEJ; non homologous end joining; VDR; vitamin D

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Non-homologous end joining pathway is the major route of protection against 4β-hydroxywithanolide E-induced DNA damage in MCF-7 cells

Keywords: ATM; ataxia-telangiectasia mutated protein; ATR; ATM and Rad3-related; 53BP1; p53 binding protein 1; BRCA1; breast cancer susceptibility protein 1; CM-H2DCFDA; 5-(and-6)-chloromethyl-20,70-dichlorodihydrofluorescein diacetate; DAPI; 4′,6-diamidino-2-phe

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Protein kinase CK2 is required for the recruitment of 53BP1 to sites of DNA double-strand break induced by radiomimetic drugs

Keywords: DSBs; DNA double-strand breaks; NHEJ; non-homologous end-joining; HR; homologous recombination; NCS; neocarzinostatin; ATM; ataxia telangiectasia mutated; MDC1; mediator of DNA damage checkpoint; 53BP1; p53-binding protein 1; BRCA1; breast cancer type 1 s

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress

Keywords: Replication stress; 53BP1; ATM; ATMIN; MEFs; mouse embryonic fibroblasts; Aph; aphidicolin; IR; ionizing radiation; Gy; Gray; MMS; methyl methanesulfonate; HU; hydroxyurea; NCS; neocarzinostatin; DAPI; diamidino-2-phenylindole; HR; homologous recombinatio

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

53BP1: pro choice in DNA repair

Keywords: 53BP1; Rif1; PTIP; NHEJ; HDR; PARPi; telomere; CSR; V(D)J; BRCA1; resection

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Reprint of “Functional overlaps between XLF and the ATM-dependent DNA double strand break response”

Keywords: Cernunnos; ATM; DNA-PKcs; NHEJ; V(D)J recombination; 53BP1;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Functional overlaps between XLF and the ATM-dependent DNA double strand break response

Keywords: Cernunnos; ATM; DNA-PKcs; NHEJ; V(D)J recombination; 53BP1;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Radiation-dose response of glycophorin A somatic mutation in erythrocytes associated with gene polymorphisms of p53 binding protein 1

Keywords: GPA Mf; glycophorin A mutant fraction; HSC; hematopoietic stem cell; 53BP1; p53 binding protein 1; Gene polymorphism; Radiation; Somatic mutation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Role of TRPM2 and TRPV1 cation channels in cellular responses to radiation-induced DNA damage

Keywords: ADPR; adenine 5′-diphosphoribose; 2-APB; 2-aminoethoxydiphenyl borate; ATM; ataxia telangiectasia mutated; 53BP1; tumor suppressor p53-binding protein 1; CAP; capsaicin; CPZ; capsazepine; DPQ; 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

DNA double‐strand break response in stem cells: Mechanisms to maintain genomic integrity

Keywords: ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; BRCA1; breast cancer type 1 susceptibility protein; CtBP; C-terminal binding protein; CtIP; CTBP interacting protein; DDR; DNA damage response; DNA-PK; DNA-dependent

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Studying the cerebellar DNA damage response in the tissue culture dish

Keywords: 53BP1; p53 binding protein 1; AOA1/2; ataxia with oculomotor apraxia type 1; A-T; ataxia-telangiectasia; A-TLD; ataxia-telangiectasia-like disorder/disease; ATM; ataxia-telangiectasia, mutated; ATR; ATM- and Rad3-related protein kinase; CaBP; calbindin pr

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

53BP1 expression in sporadic and inherited ovarian carcinoma: Relationship to genetic status and clinical outcomes

Keywords: 53BP1; BRCA1; BRCA2; Ovarian carcinoma; Homologous recombination; Non-homologous endjoining

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Tudor: a versatile family of histone methylation ‘readers’

Keywords: histone methylation; epigenetic reader; Tudor domain; JMJD2A; 53BP1; SGF29; Spindlin1; UHRF1; PHF1; PHF19; SHH1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Double strand break repair functions of histone H2AX

Keywords: Mammalian DSB repair; H2AX; MDC1; 53BP1; BRCA1; Mre11/Rad50/Nbs1; Histone code; Homologous recombination; Non-homologous end joining; Single strand annealing

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Three-dimensional imaging reveals the spatial separation of γH2AX–MDC1–53BP1 and RNF8–RNF168–BRCA1-A complexes at ionizing radiation-induced foci

Keywords: DNA damage; Ionizing radiation; Nuclear foci; γH2AX; MDC1; RNF8; RNF168; 53BP1; Abraxas (CCDC98); BRCA1; BRCC36; Merit40 (NBA1); RAP80

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of sperm DNA damage on the levels of RAD51 and p53 proteins in zygotes and 2-cell embryos sired by golden hamsters without the major accessory sex glands

Keywords: ASG; male accessory sex gland; BN; blastomere nuclei; 53BP1; p53-binding protein 1; BSA; bovine serum albumin; CAT; catalase; dsDNA; double strand DNA; FN; female pronucleus; GPx; glutathione peroxidase; H2O2; hydrogen peroxide; HR; homologous recombinati

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

The in vivo dynamic interplay of MDC1 and 53BP1 at DNA damage-induced nuclear foci

Keywords: DNA damage; Ionizing radiation; Nuclear foci; Dynamics; MDC1; 53BP1;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography

Keywords: 53BP1; Tp53 binding protein 1; 9-1-1; RAD9-RAD1-HUS1 checkpoint clamp complex; a.a.; amino acid; ACF1; ATP-utilizing chromatin assembly and remodeling factor 1; ALC1; amplified in liver cancer 1; APLF/PALF; aprataxin and PNKP-like factor; Aprataxi

دانلود رایگان متن کامل مقاله ISI 89 صفحه سال انتشار : 2012 سفارش ترجمه

When cleavage is not attractive: Non-catalytic inhibition of ubiquitin chains at DNA double-strand breaks by OTUB1

Keywords: OTUB1; RNF168; DNA damage response; Ubiquitin; 53BP1

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Protein phosphatase 5 is necessary for ATR-mediated DNA repair

Keywords: DNA damage; 53BP1; Protein phosphatase 5; ATM; ATR; UV irradiation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Rescue effects in radiobiology: Unirradiated bystander cells assist irradiated cells through intercellular signal feedback

Keywords: Radiation; Bystander effect; Radioresistance; 53BP1; Signaling transduction

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

ATM-dependent phosphorylation of 53BP1 in response to genomic stress in oxic and hypoxic cells

Keywords: 53BP1; ATM; DNA repair foci; Ionizing radiation; Hypoxia; DNA double strand breaks;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه