کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2129947 1086512 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exchange of chemical signals between cardiac cells. Fundamental role on cell communication and metabolic cooperation
ترجمه فارسی عنوان
تبادل سیگنال های شیمیایی بین سلول های قلبی؛ نقش اساسی در ارتباطات سلولی و همکاری متابولیک
کلمات کلیدی
اتصالات شکاف؛ قلب؛ ارتباطات شیمیایی؛ همکاری متابولیک
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• Gap junctions and the intercellular flow of molecules.
• Factors involved on the regulation of chemical communication.
• The heart as metabolic syncytium.
• The role of the renin angiotensin aldosterone system.
• On the possible role of epigenetic factors.

The exchange of chemical signals between cardiac cells and its relevance for cell communication and metabolic cooperation was reviewed. The role of gap junctions on the transfer of chemical information was discussed as well as the different factors involved in its regulation including changes in cell volume, high glucose, activation of the renin angiotensin aldosterone system including the intracrine effect of renin and angiotensin II on chemical coupling and cardiac energetics. Finally, the possible role of epigenetic changes of the renin angiotensin aldosterone system (RAAS) on the expression of components of the RAAS was discussed. The evidence available leads to the conception of the heart as a metabolic syncytium in which glucose as well nucleotides and hormones can flow from cell-to-cell though gap junctions, providing a new vision of how alterations in metabolic cooperation can induce cardiac diseases. These findings represent a stimulus for future research in this important area of cardiac physiology and pathology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 346, Issue 1, 1 August 2016, Pages 130–136
نویسندگان
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