کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5533244 | 1402110 | 2017 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care](/preview/png/5533244.png)
- Novel sequencing-based methods revealed that active genes are particularly prone to breakage.
- In G2, homologous recombination is favored at active genes.
- Other less characterized pathways may ensure robust sequence recovery at active genes particularly in G1.
- Transcription is subjected to a complex and dynamic regulation at damaged genes.
For decades, it has been speculated that specific loci on eukaryotic chromosomes are inherently susceptible to breakage. The advent of high-throughput genomic technologies has now paved the way to their identification. A wealth of data suggests that transcriptionally active loci are particularly fragile and that a specific DNA damage response is activated and dedicated to their repair. Here, we review current understanding of the crosstalk between transcription and double-strand break repair, from the reasons underlying the intrinsic fragility of genes to the mechanisms that restore the integrity of damaged transcription units.
Graphical Abstract159
Journal: Journal of Molecular Biology - Volume 429, Issue 9, 5 May 2017, Pages 1277-1288