Becoming a crossover-competent DSB
Keywords: شکست دو ردیف; Meiosis; Double-strand break; Crossover; Sumoylation; Ubiquitination;
مقالات ISI شکست دو ردیف (ترجمه نشده)
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DNA polymerase θ (POLQ), double-strand break repair, and cancer
Keywords: شکست دو ردیف; DSB; double-strand break; IR; ionizing radiation; altEJ; alternative end-joining; NHEJ; non-homologous end-joining; MN; micronuclei; pol θ; DNA polymerase theta; DNA polymerase; Alternative end-joining; MMEJ; DNA double strand breaks; DNA synthesis; Synt
Detection of DNA double-strand breaks in boron neutron capture reaction
Keywords: شکست دو ردیف; Neutron capture therapy; Double-strand break; DNA damage;
Biophysical characterization of the interaction between FAAP20-UBZ4 domain and Rev1-BRCT domain
Keywords: شکست دو ردیف; FA; Fanconi anemia; ICL; interstrand cross-link; DSB; double-strand break; HR; homologous recombination; MMC; mitomycin C; DEB; diepoxybutane; TLS; translesion synthesis; NER; nucleotide excision repair; FAAP20; Fanconi anemia-associated protein 20; UBZ4;
Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina
Keywords: شکست دو ردیف; mtDNA; mitochondrial DNA; NUMT; nuclear mitochondrial sequences; tRNA; transfer ribonucleic acid; rRNA; ribosomal ribonucleic acid; mya; million years ago; DSB; double-strand break; SAP; shrimp alkaline phosphatase; HIV-1; human immunodeficiency virus typ
Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV
Keywords: شکست دو ردیف; DNA double-strand break repair; Non-homologous end-joining; XRCC4; DNA ligase IV; Nuclear localization; DAPI; 4,6-diamidino-2-phenylindole dihydrochloride; DNA-PKcs; DNA-dependent protein kinase catalytic subunit; D-PBS(â); Ca2+- and Mg2+-free Dulbecco'
BLM protein mitigates formaldehyde-induced genomic instability
Keywords: شکست دو ردیف; 53BP1; p53 binding protein; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related; CGRP; calcitonin gene-related peptide; BLM; bloom protein; CHO; Chinese Hamster Ovary; DSB; double-strand break; DPC; DNA-protein crosslink; ATM;
Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos
Keywords: شکست دو ردیف; DSB; double-strand break; ES; embryonic stem (cell); HR; homologous recombination; NHEJ; non-homologous end joining; sg; single guide; TAL; transcription activator-like; TALEN; TAL effector nucleases; ZFN; zinc-finger nucleases; TALENs; Disease model; One
RNF8 deficiency results in neurodegeneration in mice
Keywords: شکست دو ردیف; Ubiquitin ligase; RNF8; DNA damage repair; Double-strand break; Neurodegeneration;
Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9
Keywords: شکست دو ردیف; 3-BrPA; 3 bromopyruvate; AOP; adverse outcome pathway; ARF4; ADP-ribosylation factor 4; BFA; brefeldin A; BT; 1,2,4-benzenetriol; CML; chronic myeloid leukemia; COSMID; CRISPR off-target sites with mismatches, insertions, and deletions; CRISPR-Cas9; clust
Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells
Keywords: شکست دو ردیف; HU; hydroxyurea; Y2H; yeast-2-hybrid; DSB; double-strand break; HR; homologous recombination; STUbL; SUMO-targeted ubiquitin ligase; SUMO; small ubiquitin-like modifier; YFP; yellow fluorescent protein; CFP; cyan fluorescent protein; RFP; red fluorescent
Systematic analysis of CRISPR-Cas9 mismatch tolerance reveals low levels of off-target activity
Keywords: شکست دو ردیف; CRISPR; clustered regularly interspaced palindromic repeats; Cas9; CRISPR associated protein 9; crRNA; CRISPR RNA; tracrRNA; trans-activating CRISPR RNA; PAM; protospacer adjacent motif; sgRNA; single guide RNA; NGS; next generation sequencing; PSC; pluri
Original ResearchFull Report: Basic and Translational-Alimentary TractGenetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes From a Subset of Patients With Familial Colorectal Carcinomas
Keywords: شکست دو ردیف; Colon Cancer; Hereditary Cancer; Genomic Instability; Tumorigenesis; BMP; bone morphogenetic protein; DSB; double-strand break; EVS; Exome Variant Server; ExAC; Exome Aggregation Consortium; FA; Fanconi's anemia; FCRC; familial colorectal cancer; HQV; h
AtMMS21 regulates DNA damage response and homologous recombination repair in Arabidopsis
Keywords: شکست دو ردیف; DSB; double-strand break; NHEJ; non-homologous end-joining; HR; homologous recombination; ATM; ATAXIA-TELANGIECTASIA MUTATED; ATR; ATM/RAD3-RELATED; SMC; structural maintenance of chromosomes; DAG; days after germination; SDSA; synthesis-dependent strand
Yeast DNA ligase IV mutations reveal a nonhomologous end joining function of BRCT1 distinct from XRCC4/Lif1 binding
Keywords: شکست دو ردیف; BRCT; BRCA1 C-terminal domain; ChIP; chromatin immunoprecipitation; DSB; double-strand break; GAL1-cs; GAL1 promoter cut-site; MRX; Mre11-Rad50-Xrs2 complex; NHEJ; nonhomologous end-joining; PCR; polymerase chain reaction; Double-strand break; Nonhomo
Atmospheric-pressure plasma jet induces DNA double-strand breaks that require a Rad51-mediated homologous recombination for repair in Saccharomyces cerevisiae
Keywords: شکست دو ردیف; Plasma jet; Rad51; Double-strand break; Homologous recombination; Reactive oxygen species
Tracing the fates of site-specifically introduced DNA adducts in the human genome
Keywords: شکست دو ردیف; TATAM; tracing DNA adducts in targeted mutagenesis; 8-oxoG; 8-oxo-7,8-dihydroguanine; TK; thymidine kinase gene; HR; homologous recombination; DSB; double-strand break; MYH; human MutY homolog; DNA adducts; Mutagenesis; Gene targeting; 8-Oxoguanine (8-oxo
DNA double-strand breaks activate ATM independent of mitochondrial dysfunction in A549 cells
Keywords: شکست دو ردیف; ATM; ataxia telangiectasia mutant; DSB; double-strand break; HA; hemagglutinin antigen epitope tag; KAP1; KRAB-associated protein-1; MTS; mitochondrial targeting sequence; NLS; nuclear localization sequence; ROS; reactive oxygen species; SMC1; structural
Sgs1 and Exo1 suppress targeted chromosome duplication during ends-in and ends-out gene targeting
Keywords: شکست دو ردیف; HR; homologous recombination; EOGT; ends-out gene targeting; EIGT; ends-in gene targeting; DSB; double-strand break; TCD; targeted chromosome duplication; BIR; break-induced replication; bp; base pair; kb; kilobase; nt; nucleotide; PFGE; pulsed-field gel
Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1
Keywords: شکست دو ردیف; HR; homologous recombination; DSB; double-strand break; NTD; N-terminal domain; Dmc1 recombinase; Homologous recombination; Meiosis;
C-terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin
Keywords: شکست دو ردیف; IR; ionizing radiation; DSB; double-strand break; NHEJ; non-homologous end-joining; PNKP; polynucleotide kinase/phosphatase; LIG4; DNA ligase IV; APLF; aprataxin- and PNK-like factor; BRCT; breast cancer associated 1 C-terminal; FBS; fetal bovine serum; L
Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up
Keywords: شکست دو ردیف; bp; base-pair; DDR; DNA damage response; DNA-PKcs; catalytic subunit of the DNA-dependent protein kinase; DSB; DNA Double-Strand Break; HR; homologous recombination; IR; ionizing radiation; IRIF; ionizing radiation induced foci; LET; Linear Energy Transfe
Sodium tungstate modulates ATM function upon DNA damage
Keywords: شکست دو ردیف; DNA damage; Antitumoral; Double-strand break; Phosphatase inhibition;
Intrachromosomal homologous recombination between inverted amplicons on opposing Y-chromosome arms
Keywords: شکست دو ردیف; MSY; male-specific region of the Y chromosome; NAHR; non-allelic homologous recombination; AZFc; azoospermia factor c; IR; inverted repeat; DSB; double-strand break; STS; sequence-tagged site; FISH; fluorescence in situ hybridization; PAR; pseudoautosomal
DNA-protein crosslinks processed by nucleotide excision repair and homologous recombination with base and strand preference in E. coli model system
Keywords: شکست دو ردیف; DNA-protein crosslinks; Nucleotide excision repair; MGMT; Dibromoethane; Epibromohydrin; AGT (MGMT); O6-alkylguanine-DNA alkyltransferase; hAGT; human wild type AGT; NER; nucleotide excision repair; TC-NER; transcription-coupled NER; GC-NER; global geno
Modification of DNA damage mechanisms by nitric oxide during ionizing radiation
Keywords: شکست دو ردیف; dGMP; 2â²-deoxyguanosine monophosphate; dG; 2â²-deoxyguanosine; dXMP; 2â²-deoxyxanthosine monophosphate; 8azadGMP; 2â²-deoxy-8-azaguanosine monophosphate; 8oxodGMP; 8-oxo-2â²-deoxyguanosine monophosphate; FaPydGMP; (2â²-deoxypentopyranosyl)-2,6-diam
Cohesin: Functions beyond sister chromatid cohesion
Keywords: شکست دو ردیف; DSB; double-strand break; SPB; spindle pole body; SCC; sister chromatid cohesion; SC; synaptonemal complex; AE; axial element; LE; lateral element; CE; central element; CdLS; Cornelia de Lange syndrome; RBS; Roberts syndrome; CTCF; CCCTC binding factor; M
ITPA (inosine triphosphate pyrophosphatase): From surveillance of nucleotide pools to human disease and pharmacogenetics
Keywords: شکست دو ردیف; Nucleotide pool; ITPA gene polymorphism; Pharmacogenetics; Base analogs; Mercaptopurines; Protein stability; Dominant negative; ITPA; inosine triphosphate pyrophosphatase; ITP; inosine triphosphate; XTP; xanthosine triphosphate; HAM1; Saccharomyces cerevi
Repair of chromosomal double-strand breaks by precise ligation in human cells
Keywords: شکست دو ردیف; Double-strand break; Precise ligation; NHEJ
Touching base with PARPs: moonlighting in the repair of UV lesions and double-strand breaks
Keywords: شکست دو ردیف; DNA repair; poly(ADP-ribose) polymerase (PARP); double-strand break; UV-induced DNA damage; nucleotide excision repair; homologous recombination; non-homologous end-joining
ETV6/RUNX1 Induces Reactive Oxygen Species and Drives the Accumulation of DNA Damage in B Cells
Keywords: شکست دو ردیف; BCP-ALL; B cell precursor-acute lymphoblastic leukemia; ROS; reactive oxygen species; DSB; double-strand break; DHE; dihydroethidium; E/Rtg; ETV6/RUNX1 transgene;
The type of mutations induced by carbon-ion-beam irradiation of the filamentous fungus Neurospora crassa
Keywords: شکست دو ردیف; Carbon-ion beam; Double-strand break; Heavy-ion beam; Homologous recombination repair; Neurospora crassa; Nonhomologous end-joining
Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity
Keywords: شکست دو ردیف; Ataxia telangiectasia; class switch recombination; somatic hypermutation; κ-deleting recombination excision circle; hypogammaglobulinemia; B-cell subsets; T-cell subsets; AT; Ataxia telangiectasia; ATM; Ataxia telangiectasia mutated; DSB; Double-strand b
Ewing's sarcoma: Analysis of single nucleotide polymorphism in the EWS gene
Keywords: شکست دو ردیف; °C; Degrees Celsius; dbSNP; SNP DataBase; DSB; Double-strand break; DNA; Deoxyribonucleic acid; ERG; Ets Related Gene; ETS; E-twenty six; EWS; Ewing sarcoma breakpoint region 1; FLI1; Friend leukemia virus integration 1; HCPA; UFRGS university hospital;
Radiosensibilité individuelle et risque aux faibles doses médicales
Keywords: شکست دو ردیف; Radiosensibilité; Faibles doses; Susceptibilité au cancer; Mammographie; ADN; Cassure double-brinRadiosensitivity; Low-doses; Cancer susceptibility; Mammography; DNA; Double-strand break
Regulation of DNA repair by S-nitrosylation
Keywords: شکست دو ردیف; 8-oxoG; 8-oxoguanine; AGT; O6-alkylguanine-DNA-alkyltransferase; AP; apurinic-apyrimidinic; APE1; AP endonuclease 1; BER; base excision repair; DEN; diethylnitrosamine; DNA-PKcs; DNA-dependent protein kinase catalytic subunit; DSB; double-strand break; DT
Bmi-1 confers adaptive radioresistance to KYSE-150R esophageal carcinoma cells
Keywords: شکست دو ردیف; ESCC; esophageal squamous cell carcinoma; RT; radiation therapy; FIR; fractionated irradiation; ROS; reactive oxygen species; SA β-Gal; senescence-associated β-galactosidase; IR; ionizing radiation; DSB; double-strand break; Lpo; lactoperoxidase; Adapti
Telomere dysfunction and chromosome instability
Keywords: شکست دو ردیف; A-NHEJ; alternative nonhomologous end joining; B/F/B; breakage/fusion/bridge; C-NHEJ; classical nonhomologous end joining; DSBs; double-strand breaks; GCRs; gross chromosome rearrangements; HSV-tk; herpes simplex thymidine kinase; NHEJ; nonhomologous end
Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility
Keywords: شکست دو ردیف; Genomic instability; Double-strand break; Altered DNA structures; DNA damage; Nonhomologous DNA end joining; Chromosomal translocation
Regulation and protection of mitochondrial physiology by sirtuins
Keywords: شکست دو ردیف; Acetyl-CoA; acetyl-coenzyme A; AceCS2; acetyl-coenzyme A synthethase 2; ACC; Acetyl-CoA carboxylase; ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPK; 5â² adenosine monophosphate-activated protein kinase; ANT; adenine nucleotide transloca
Molecular nature of mutations induced by high-LET irradiation with argon and carbon ions in Arabidopsis thaliana
Keywords: شکست دو ردیف; Arabidopsis thaliana; Double-strand break; Heavy-ion irradiation; Large deletions; Linear energy transfer; Mutation
Heterogeneous telomere defects in patients with severe forms of dyskeratosis congenita
Keywords: شکست دو ردیف; Telomere; dyskeratosis congenita; Hoyeraal-Hreidarsson syndrome; senescence; immune deficiencies; bone marrow failure; CO-FISH; Chromosome orientation-fluorescence in situ hybridization; DC; Dyskeratosis congenita; DSB; Double-strand break; HH; Hoyeraal
NF-κB Essential Modifier Is Required for Hepatocyte Proliferation and the Oval Cell Reaction After Partial Hepatectomy in Mice
Keywords: شکست دو ردیف; PEITC; Liver Disease; Mouse Model; Tissue Regeneration; BHA; butylated hydroxyanisole; BrdU; 5-bromo-2â²-deoxyuridine; DAPI; 4â²,6-diamidino-2-phenylindole; DDC; 3,5-diethoxycarbonyl-1,4-dihydro-collidin; DSB; double-strand break; FHC; ferritin heavy ch
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography
Keywords: شکست دو ردیف; 53BP1; Tp53 binding protein 1; 9-1-1; RAD9-RAD1-HUS1 checkpoint clamp complex; a.a.; amino acid; ACF1; ATP-utilizing chromatin assembly and remodeling factor 1; ALC1; amplified in liver cancer 1; APLF/PALF; aprataxin and PNKP-like factor; Aprataxi
Anaphase DNA bridges induced by lack of RecQ5 in Drosophila syncytial embryos
Keywords: شکست دو ردیف; DSBs; double-strand breaks; Mnk; maternal nuclear kinase; PH3; phosphorylated histone H3; His2Av-mRFP1; monomeric red fluorescent protein 1-tagged histone 2AvD; DAPI; 4â²,6-diamidino-2-phenylindole; PI; propidium iodide; RecQ; DNA repair; Double-strand b
Occult hepatitis C virus elicits mitochondrial oxidative stress in lymphocytes and triggers PI3-kinase-mediated DNA damage response
Keywords: شکست دو ردیف; 8-oxo-dG; 8-oxo-2â²-deoxyguanosine; ALT; alanine transferase; ARP; aldehyde-reactive probe; CM-H2DCFDA; 5-(and-6)-chloromethyl-2â²,7â²-dichlorodihydrofluorescein diacetate acetyl ester; DCF; 2â²,7â²-dichlorofluorescin; DSB; double-strand break; EDTA;
Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair
Keywords: شکست دو ردیف; Chromosome instability; Double-strand break; Nonhomologous end joining; Telomere
Separable roles for Exonuclease I in meiotic DNA double-strand break repair
Keywords: شکست دو ردیف; EXO1; Meiosis; Recombination; Resection; Double-strand break
Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation
Keywords: شکست دو ردیف; IR; ionizing radiation; DSB; double-strand break; LET; linear energy transfer; EGFP; enhanced green fluorescent protein; NHEJ; non-homologous end-joining; HR; homologous recombination; WRN; Werner syndrome protein; Clustered DNA damage; Ionizing radiation
Rejoining of gamma-ray-induced DNA damage in Cryptosporidium parvum measured by the comet assay
Keywords: شکست دو ردیف; Cryptosporidium parvum; Radiation; DNA damage; Double-strand break;