کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2820762 1160889 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility
چکیده انگلیسی

Genetic alterations like point mutations, insertions, deletions, inversions and translocations are frequently found in cancers. Chromosomal translocations are one of the most common genomic aberrations associated with nearly all types of cancers especially leukemia and lymphoma. Recent studies have shown the role of non-B DNA structures in generation of translocations. In the present study, using various bioinformatic tools, we show the propensity of formation of different types of altered DNA structures near translocation breakpoint regions. In particular, we find close association between occurrence of G-quadruplex forming motifs and fragile regions in almost 70% of genes involved in rearrangements in lymphoid cancers. However, such an analysis did not provide any evidence for the occurrence of G-quadruplexes at the close vicinity of translocation breakpoint regions in nonlymphoid cancers. Overall, this study will help in the identification of novel non-B DNA targets that may be responsible for generation of chromosomal translocations in cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 100, Issue 2, August 2012, Pages 72–80
نویسندگان
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