کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8456004 | 1548363 | 2011 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation
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کلمات کلیدی
DSBeGFPNHEJWRNHZE particlesLET - اجازه دهیدLinear Energy Transfer - انتقال انرژی خطیHigh-LET - بالا LETionizing radiation - تابش یوننده یا پرتوهای یونیزانClustered DNA damage - خسارت DNA خوشه ایdouble-strand break - شکست دو ردیفnon-homologous end-joining - عدم پیوستن به همولوگHomologous recombination - نوترکیبی همولوگWerner syndrome protein - پروتئین سندرم ورنرenhanced green fluorescent protein - پروتئین فلورسنت سبز افزایش یافته است
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Low-linear energy transfer (LET) radiation (i.e., γ- and X-rays) induces DNA double-strand breaks (DSBs) that are rapidly repaired (rejoined). In contrast, DNA damage induced by the dense ionizing track of high-atomic number and energy (HZE) particles is slowly repaired or is irreparable. These unrepaired and/or misrepaired DNA lesions may contribute to the observed higher relative biological effectiveness for cell killing, chromosomal aberrations, mutagenesis, and carcinogenesis in HZE particle irradiated cells compared to those treated with low-LET radiation. The types of DNA lesions induced by HZE particles have been characterized in vitro and usually consist of two or more closely spaced strand breaks, abasic sites, or oxidized bases on opposing strands. It is unclear why these lesions are difficult to repair. In this review, we highlight the potential of a new technology allowing direct visualization of different types of DNA lesions in human cells and document the emerging significance of live-cell imaging for elucidation of the spatio-temporal characterization of complex DNA damage. We focus on the recent insights into the molecular pathways that participate in the repair of HZE particle-induced DSBs. We also discuss recent advances in our understanding of how different end-processing nucleases aid in repair of DSBs with complicated ends generated by HZE particles. Understanding the mechanism underlying the repair of DNA damage induced by HZE particles will have important implications for estimating the risks to human health associated with HZE particle exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 711, Issues 1â2, 3 June 2011, Pages 87-99
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 711, Issues 1â2, 3 June 2011, Pages 87-99
نویسندگان
Aroumougame Asaithamby, David J. Chen,