کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1980153 | 1539407 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AtMMS21 regulates DNA damage response and homologous recombination repair in Arabidopsis
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کلمات کلیدی
DSBSMCATRNHEJSDSAsynthesis-dependent strand annealingataxia-telangiectasia mutated - Ataxia-Telangiectasia جهش یافته استArabidopsis thaliana - آرابیدوپسیس تالیاناATM - خودپردازDAG - روزdays after germination - روز بعد از جوانه زدنdouble-strand break - شکست دو ردیفnon-homologous end-joining - عدم پیوستن به همولوگHomologous recombination - نوترکیبی همولوگstructural maintenance of chromosomes - نگهداری ساختاری کروموزوم هاDNA damage response - واکنش به آسیب DNA
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: AtMMS21 regulates DNA damage response and homologous recombination repair in Arabidopsis AtMMS21 regulates DNA damage response and homologous recombination repair in Arabidopsis](/preview/png/1980153.png)
چکیده انگلیسی
DNA damage is a significant problem in living organisms and DNA repair pathways have been evolved in different species to maintain genomic stability. Here we demonstrated the molecular function of AtMMS21, a component of SMC5/6 complex, in plant DNA damage response. Compared with wild type, the AtMMS21 mutant plants show hypersensitivity in the DNA damaging treatments by MMS, cisplatin and gamma radiation. However, mms21-1 is not sensitive to replication blocking agents hydroxyurea and aphidicolin. The expression of a DNA damage response gene PARP2 is upregulated in mms21-1 under normal condition, suggesting that this signaling pathway is constitutively activated in the mutant. Depletion of ATAXIA-TELANGIECTASIA MUTATED (ATM) in mms21-1 enhances its root growth defect phenotype, indicating that ATM and AtMMS21 may play additive roles in DNA damage pathway. The analysis of homologous recombination frequency showed that the number of recombination events is reduced in mms21-1 mutant. Conclusively, we provided evidence that AtMMS21 plays an important role in homologous recombination for DNA damage repair.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 21, September 2014, Pages 140-147
Journal: DNA Repair - Volume 21, September 2014, Pages 140-147
نویسندگان
Dongke Yuan, Jianbin Lai, Panglian Xu, Shengchun Zhang, Juanjuan Zhang, Chunxin Li, Yaqin Wang, Jinju Du, Yiyang Liu, Chengwei Yang,