کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5533095 | 1550355 | 2017 | 7 صفحه PDF | دانلود رایگان |
- R-loops are an important source of DNA damage and genome instability.
- DNA repair proteins implicated in tumor suppression limit R-loop-induced DNA damage.
- DNA replication fork protection may exert an anti-R-loop effect.
DNA repair defects create cancer predisposition in humans by fostering a higher rate of mutations. While DNA repair is quite well characterized, recent studies have identified previously unrecognized relationships between DNA repair and R-loop-mediated genome instability. R-loops are three-stranded nucleic acid structures in which RNA binds to genomic DNA to displace a loop of single-stranded DNA. Mutations in homologous recombination, nucleotide excision repair, crosslink repair, and DNA damage checkpoints have all now been linked to formation and function of transcription-coupled R-loops. This perspective will summarize recent literature linking DNA repair to R-loop-mediated genomic instability and discuss how R-loops may contribute to mutagenesis in DNA-repair-deficient cancers.
Graphical Abstract226
Journal: Journal of Molecular Biology - Volume 429, Issue 21, 27 October 2017, Pages 3132-3138