Keywords: CA1; Cornu Ammonis area 1; CA3; Cornu Ammonis area 3; CK2a; calmodulin kinase 2A; DG; dendate gyrus; DMEM; Dulbecco's modified Eagle's médium; DMSO; dimethylsulfoxide; DTNB; 5,5â²-dithio-bis-(2-nitrobenzoic acid); FBS; fetal bovine serum; GCL; glutamate
مقالات ISI (ترجمه نشده)
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Keywords: Mitochondria; Ubiquitin; Neurodegeneration; E3 ligase; Mitochondria-derived vesicles; PD; Parkinson's disease; MDV; mitochondria-derived vesicle; DA; dopaminergic; SN; substantia nigra; GWAS; genome-wide association study; OMM; outer mitochondrial membran
Keywords: DD; Danon disease; LAMP2; lysosome associated membrane protein 2; XCI; X-chromosome inactivation; iPSCs; induced pluripotent stem cells; iPSC-CMs; induced pluripotent stem cells derived cardiomyocytes like cells; PBMCs; peripheral blood mononuclear cells;
Keywords: ROS; reactive oxygen species; Prx; peroxiredoxin; PTP1B; protein tyrosine phosphatase 1B; PTEN; phosphatase and tensin homologue; MEFs; mouse embryonic fibroblasts; Nac; N-acetyl cysteine; GTT; glucose tolerance test; GLUT4; glucose transporter type 4; PT
Keywords: ASC; adult stem Cell; ASN; auditory sensory neurons; Atoh1; protein atonal homolog 1; bFGF; basic fibroblast growth factor; bHLH; basic helix-loop-helix; BDNF; brain-derived neurotrophic factor; BMP4; bone morphogenetic protein 4; CDK; cyclin-dependent ki
Keywords: BP; Bereitschaftspotential; CMC; Cortico-muscular coherence; ECD; equivalent current dipole; EEG; electroencephalography; EMG; electromyogram; EOG; electrooculogram; HPI; head position indicator; M1; primary motor cortex; MEFs; motor-evoked fields; MEG; m
Keywords: OASL; 2'-5'-oligoadenylate synthetase; PKR; double-stranded RNA-dependent protein kinase; GAS; gamma-activated site; HCMV; human cytomegalovirus; ISG; IFN-I-stimulated genes; IFNAR; interferon alpha receptor; IFNGR; interferon gamma receptor; IRF; interfe
Keywords: 8-OHG; 8-hydroxyguanosine; HNE; hydroxy-2-nonenal; IF; immunofluorescence; MEFs; mouse embryonic fibroblasts; PBS; phosphate-buffered saline; TPH2; tryptophan hydroxylase-2; ZS; Zellweger syndrome; Zellweger syndrome; PEX13 deficiency; mitochondria; oxida
Keywords: Nifedipine (PubChem CID: 4485); E4031 (PubChem CID: 3185); Dofetilide (PubChem CID: 71329); Lidocaine (PubChem CID: 3676); ZD7288 (PubChem CID: 123983); Verapamil (PubChem CID: 2520); Azimilide (PubChem CID: 9571004); Ranolazine (PubChem CID: 56959); Tert
Keywords: EMT; epithelial to mesenchymal transition; HS; heat shock; HSF1; heat shock transcription factor 1; HSPs; heat shock proteins; MEFs; mouse embryonic fibroblasts; Vinculin; Adhesion; Anchorage-independent growth; Metastasis; Thermotolerance;
Keywords: Atg; autophagy-related gene; Baf A1; bafilomycin A1; BHMT; betaine homocysteine methyltransferase; 14C; radiocarbon; Con A; concanamycin A; F; farad; GFP; green fluorescent protein; GST; gluthathione S-transferase; 3H; tritium; KO; knockout; LDH; lactate
Keywords: DIQ; 1,5-dihydroxyisoquinoline; 4-AN; 4-amino-1,8-naphthalimide; 6,4PPs; 6,4-photoproducts; 8-oxodG; 8-oxo-2â²-deoxyguanosine; OGG1; 8-oxoguanine glycosylase 1; APE1; AP-endonuclease; ATM; ataxia telangiectasia-mutated gene; BER; base excision repair; BR
Keywords: AceCS2; acetyl-CoA synthetase 2; ADP; adenosine diphosphate; CPS1; carbamoyl phosphate synthetase 1; CPT1; carnitine palmitoyltransferase I; CR; calorie restriction; FOXO3a; forkhead box 03a; GDH; glutamate dehydrogenase; HeLa; human cervical carcinoma ce
Keywords: BrdU; bromodeoxyuridine; bHLH; basic helix-loop-helix; CNS; central nervous system; CPPs; cell-penetrating peptides; DCX; doublecortin; EGF; epidermal growth factor; (E)GFP; (enhanced) green fluorescent protein; ESCs; embryonic stem cells; FGF; fibrob
Keywords: Stiffness; Topography; Stem cell; Stemness; Morphology; CM; conditioned medium; EBs; embryoid bodies; ECM; extracellular matrix; KSR; knockout serum replacement; LIF; leukemia inhibitory factor; MEFs; mouse embryonic fibroblasts; mESCs; mouse embryonic st
Keywords: Akt; protein kinase B (PKB); α-KG; α-ketoglutarate; AMPK; AMP-activated protein kinase; BPTES; bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide; ÎΨm; mitochondrial membrane potential; ÎΨp; plasma membrane potential; ÎpH; mitochondrial p
Keywords: ASK1; apoptosis signal-regulating kinase 1; ATF4; activating transcription factor 4; ATF6; activating transcription factor 6; Bcl-2; B-cell lymphoma 2; BiP; binding immunoglobulin protein; bZIP; basic leucine zipper; CDK; cyclin-dependent kinase; CDKI; CD
Keywords: BSA; Bovine Serum Albumin; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's Modified Eagle's Medium; ECM; extracellular matrix; PBS; phosphate-buffered saline; FAK; focal adhesion kinase; FCS; fetal calf serum; HMDS; hexamethyldisiloxane; LIM; lin-
Caspase-2 associates with FAN through direct interaction and overlapping functionality
Keywords: FAN; Caspase-2; Lysozyme; Ceramide specie; Cell migration; BEACH; Beige and Chediak-Higashi; ELISA; Enzyme-linked immunosorbent assay; FAN; Factor associated with neutral sphingomyelinase activation; HPLC-MS/MS; High performance liquid chromatography-tand
AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2
Keywords: AICAR; 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside; AMPK; adenosine monophosphate-activated protein kinase; CTGF; connective tissue growth factor (CCN2); CYR61; cysteine-rich angiogenic protein 61; HPRT; hypoxanthine-guanine phosphoribosyl transf
Both ganglioside GM2 and cholesterol in the cell membrane are essential for Bombyx mori cypovirus cell entry
Keywords: Bombyx mori; Cytoplasmic polyhedrosis virus; Ganglioside GM2; Membrane cholesterol; Infectivity; BmCPV; Bombyx mori cypovirus; S1S10; 10 dsRNAs segments; NSP; non-structural proteins; VAP; virus attachment proteins; JAM-A; junctional adhesion molecule A;
Functional failure of TLR3 and its signaling components contribute to herpes simplex encephalitis
Keywords: HSE; herpes simplex encephalitis; TLR3; Toll-like receptor 3; VSV; vesicular stomatitis virus; MCMV; murine cytomegalovirus; EE; early endosomes; LE; late endosomes; EL; endolysosomal compartment; BFA; Brefeldin A; TGN; trans-Golgi network; KSHV; Kaposi's
p63 Silencing induces reprogramming of cardiac fibroblasts into cardiomyocyte-like cells
Keywords: cellular reprogramming; transdifferentiation; heart failure; myocardial infarction; regenerative medicine; induced-cardiomyocytes (iCMs); Ad; adenovirus; Ad-Cre; Ad encoding Cre recombinase; Ad-GFP; Ad encoding GFP control vector; BCM; Baylor College of M
The ciliary protein Rpgrip1l in development and disease
Keywords: BB; Basal body; Bbs; Bardet-Biedl syndrome; C. elegans; Caenorhabditis elegans; CC; Coiled-Coil; Cep290; Centrosomal Protein 290; COACH; Cerebellar Vermis Aplasia Oligophrenia Congenital Ataxia Coloboma Hepatic Fibrosis; CRD; Cone Rod Dystrophy; Cux1; Cut
Combining mouse embryonic stem cells and zebrafish embryos to evaluate developmental toxicity of chemical exposure
Keywords: α/β-Cardiac Myosin; Heavy chain Alpha and Beta Cardiac Myosin; ABCG2; ATP-Binding Cassette sub-family G member 2; ANOVA; Analysis of Variance; DMEM; Dulbecco's Modified Eagle Medium; DMSO; Dimethyl Sulfoxide; DPBS; Dulbecco's Phosphate-Buffered Sali
Deubiquitylating enzymes as cancer stem cell therapeutics
Keywords: Protein-IPSC; protein-induced pluripotent stem cells; CSCs; cancer stem cells; DUBs; deubiquitylating enzymes; ESCs; embryonic stem cells; PTMs; post-translational modifications; AML; acute myelogenous leukemia; USP/UBP; ubiquitin-specific processing prot
A Trichostatin A (TSA)/Sp1-mediated mechanism for the regulation of SALL2 tumor suppressor in Jurkat T cells
Keywords: AP4; Activating Protein 4; BAX; Bcl-2-associated X protein; Brd4; Bromodomain-containing protein 4; Brg1; Brahma-related gene-1; C2H2; Cys2-His2 zinc finger; CBP; CREB-binding protein; CDKN2A; Cyclin-Dependent Kinase Inhibitor 2A gene; CDKN1A; Cyclin-Depe
Role of kinase-coupled TRP channels in mineral homeostasis
Keywords: AC; acylcarnitines; ALPase; alkaline phosphatase; ALS-G; amyotrophic lateral sclerosis; ARE; antioxidant response elements; CC domain; coiled-coil domain; CPT; carnitine palmitoyltransferases; CS; corpuscles of Stannius; GPCR; G protein-coupled receptor;
ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress
Keywords: MEFs; murine embryonic fibroblasts; Aphidicolin; ASCIZ; ATM; ATMIN; DYNLL1; 53BP1;
Redox regulation of proteasome function
Keywords: Abcd1; ATP binding cassette subfamily D member 1; AD; Alzheimer's disease; ALD; adrenoleukodystrophy; ALS; amyotrophic lateral sclerosis; AP-1; activator protein-1; APP; amyloid precursor protein; CNS; central nervous system; DDI; DNA-damage inducible 1;
Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition
Keywords: Smurf1; Securin; Ubiquitination; Metaphase-to-anaphase transition; MEFs;
Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development
Keywords: HU; hydroxyurea; APH; aphidicolin; MN; micronuclei; 53BP1-NBs; 53BP1-nuclear bodies; MEFs; mouse embryonic fibroblasts; B6; C57BL/6; C3H; C3HeB/; CNAs; copy number alterations; ICLs; inter-strand crosslinks; DDR; DNA damage repair/response; FA; Fanconi an
Molecular basis for the regulation of the circadian clock kinases CK1δ and CK1ε
Keywords: ATP; adenosine triphosphate; CK1; casein kinase 1; CK2; casein kinase 2; CTD; C-terminal domain; TTFL; transcriptional and translational feedback loop; GSK-3β; glycogen synthase kinase 3β; MEFs; mouse embryonic fibroblast cells; ConA; concanavalin A; LP
Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis
Keywords: SK; Sphingosine Kinase; Sph; Sphingosine; S1P; Sphingosine 1-phosphate; Cer; Ceramide; 17C-Sph; 17 carbon chain sphingosine; 17C-S1P; 17 carbon chain sphingosine 1-phosphate; DSS; dextran sodium sulfate; IBD; inflammatory bowel disease; MEFs; mouse embryo
Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative
Keywords: Nrf2; nuclear factor erythroid 2-related factor 2; SSc; systemic sclerosis; TGF-β; transforming growth factor beta; CDDO; 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid; TMC; 2-trifluoromethyl-2'-methoxychalcone; SFN; sulforaphane; α-SMA; alpha smooth m
The expanding horizon of MicroRNAs in cellular reprogramming
Keywords: OSK (3 factors); OCT4, SOX2, KLF4; OSKM (4 factors); OCT4, SOX2, KLF4, MYC; ESCs; Embryonic stem cells; MEFs; Mouse embryonic fibroblasts; iPSCs; Induced pluripotent stem cells; MBD2; methyl DNA binding domain protein 2; MECP1/2; methyl-CpG binding protei
GPR120 in adipocytes has differential roles in the production of pro-inflammatory adipocytokines
Keywords: Obesity; Extracellular matrix remodeling factor; Protein kinase C; Toll-like receptors; Ï-3 polyunsaturated fatty acids; Ï-3 PUFA; Ï-3 polyunsaturated fatty acid; DHA; docosahexaenoic acid; ECM; extracellular matrix; EPA; eicosapentaenoic acid; GPR120;
Functional relevance of miRNAs in premature ageing
Keywords: CRP; C-reactive protein; DDR; DNA damage response; DSB; double-strand breaks; HATs; histone acetyltransferases; HDACs; histone deacetylases; hMSCs; human mesenchymal stem cells; HRR; homologous recombination repair; MEFs; mouse embryonic fibroblast; ROS;
Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice
Keywords: Circadian clock; Peripheral tissue; Chronopharmacology; Period 2; Kidney; CT; circadian time; MEFs; mouse embryonic fibroblasts; PER2::LUC; PERIOD2::LUCIFERASE; ZT; zeitgeber time;
Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells
Keywords: AMPK; AMP-activated protein kinase; AO; acridine orange; AVOs; acidic vesicular organelles; FGF-2; fibroblast growth factor 2; Grb2; growth factor receptor binding protein 2; Rab13; Ras-related protein in brain 13; HA; hemagglutinin; HRP; Horseradish pero
Methylglyoxal-induced AMPK activation leads to autophagic degradation of thioredoxin 1 and glyoxalase 2 in HT22 nerve cells
Keywords: ACC; acetyl co-enzyme A carboxylase; AGE; advanced glycation end products; AMPK; 5â² AMP-activated protein kinase; ATG; autophagy related; BAF; bafilomycin; CQ; chloroquine; DMEM; high-glucose Dulbecco's modified Eagle medium; Glo; glyoxalase; GSH; gluta
Redox regulation of the tumor suppressor PTEN by the thioredoxin system and cumene hydroperoxide
Keywords: AP-1; activator protein-1; DMEM; Dulbecco's modified Eagle's medium; DTT; dithiothreitol; FBS; fetal bovine serum; Grx; glutaredoxin; GSH; glutathione; HPLC; high- performance liquid chromatography; HRP; horseradish peroxidase; MEFs; mouse embryonic fibro
IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells
Keywords: ATF6; activating transcription factor 6; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; HNF4α; hepatocyte nuclear factor 4α; GAP; GTPase-activating protein; HFD; high fat diet; IL-4; interleukin-4; IRE1α; inositol-requiring enzyme 1
The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress
Keywords: 3-AT; 3-amino-1,2,4-triazole; -T; SV40 large T antigen-transformed; dpt; days post-transfection; HuFs; human fibroblasts; MEFs; mouse embryonic fibroblasts; NAC; N-acetylcysteine; Nb; nanobody; NLS; nuclear localization signal; PEX; protein involved in pe
MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6
Keywords: MicroRNA-33; Cellular senescence; CDK6; Proliferation; MEFs; Mouse Embryonic Fibroblasts; SA-β-gal; Senescence-associated β-galactosidase staining; CDK6; cyclin-dependent protein kinase 6;
O-GlcNAc is required for the survival of primed pluripotent stem cells and their reversion to the naïve state
Keywords: Embryonic stem cells; ESC-derived epiblast stem cells; O-GlcNAc; O-GlcNAc transferase; O-GlcNAcase; ESCs; mouse embryonic stem cells; EpiSCs; mouse epiblast stem cells; ESD-EpiSCs; ESC-derived EpiSCs; rESCs; reverted ESCs; O-GlcNAc; O-linked β-N-acetylgl
The protein phosphatase 6 catalytic subunit (Ppp6c) is indispensable for proper post-implantation embryogenesis
Keywords: Protein phosphatase 6 catalytic subunit (Ppp6c); Growth failure; Inner cell mass (ICM); MEFs; Post-implantation; Embryogenesis;
Research ArticleOverexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts
Keywords: MEFs; Mouse embryonic fibroblasts; ChIP-seq; Chromatin Immunoprecipitation and DNA sequencing; Mouse embryonic fibroblasts; Histone demethylases; Fbxl10; Migration;
Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity
Keywords: ADM; adipogenic differentiation medium; AA; arachidonic acid; cPLA2α; cytosolic group IVA phospholipase A2α; MCE; mitotic clonal expansion; ASCs; adipose stem cell; MEFs; mouse embryonic fibroblast; HFD; high fat diet; MTT; 3-(4.5-dimethylthiazol-2-yl)-
ReviewEngineering cell fate: Spotlight on cell-activation and signaling-directed lineage conversion
Keywords: iPSCs; Induced Pluripotent Stem Cells; MEFs; Mouse Embryonic Fibroblasts; CASD; Cell-Activation and Signaling-Directed; GRNs; Gene Regulatory Networks; TRN; Transcriptional Regulatory Network; PDGF; Platelet-derived growth factor; FLT3LG or Flt-3L; Flt3 l