کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2147623 1548424 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Detection of deletions flanked by short direct repeats in mitochondrial DNA of aging Drosophila
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Detection of deletions flanked by short direct repeats in mitochondrial DNA of aging Drosophila
چکیده انگلیسی

Cumulative damage due to reactive oxygen species (ROS) in mitochondria, especially in mitochondrial DNA (mtDNA), would result in a decrease in mitochondrial respiratory function and contributes to the age-related decline in the physiological functioning of organisms. Previously, we reported the tissue-specific accumulation of deleted mtDNA with age in Drosophila melanogaster. In the present study, to understand the mechanism by which mtDNA deletion is generated with age, nucleotide sequences of deleted mtDNA were determined. Consequently, 33 different sequences each containing a deletion were obtained from flies that were more than 55-day-old. Most of the deletions were found to be flanked by short direct repeats. The present results, together with those from other animals, suggest that there is a common mechanism generating mtDNA deletions through direct repeats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 594, Issues 1–2, 22 February 2006, Pages 155–161
نویسندگان
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