کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2149469 1548644 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antioxidant and antimutagenic activity of mannan neoglycoconjugates: Mannan–human serum albumine and mannan–penicillin G acylase
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Antioxidant and antimutagenic activity of mannan neoglycoconjugates: Mannan–human serum albumine and mannan–penicillin G acylase
چکیده انگلیسی

The antioxidant and antimutagenic activity of the yeast cell-wall mannan and mannan conjugates – in particular the mannan of Saccharomyces cerevisiae (M-S.c.) and conjugates of mannan S. cerevisiae with human serum albumine (M-HSA1, M-HSA2) and the microbial enzyme penicillin G acylase (M-PGA) – were evaluated in vitro in the unicellular flagellate Euglena gracilis exposed to the genotoxic agents ofloxacin and acridine orange (AO). M-S.c., M-HSA1, M-HSA2 and M-PGA show a statistically significant, concentration-dependent protective antigenotoxic activity against both compounds. M-PGA was the most efficient inhibitor of ofloxacin- and AO-induced chloroplast DNA damage, whereas M-HSA2 and M-HSA1 were less effective and M-S.c. had the lowest antigenotoxic activity. It is suggested that different mechanisms may be involved in their protective effect—antioxidant activity in the case of ofloxacin-induced DNA damage and direct adsorption of AO on mannan conjugates as possible mechanisms of protection, based on spectrophotometric measurements. The important characteristics of yeast cell-wall mannans and mannan conjugates, such as their high water solubility, their broad spectrum of biological activity, low toxicity, stability and their antimutagenic effects via different modes of action, appear to be promising features for their practical application as antioxidants and antimutagenic agents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 606, Issues 1–2, 14 July 2006, Pages 72–79
نویسندگان
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