Genome-wide Association Study Identifies Loci at ATF7IP and KLK2 Associated with Percentage of Circulating Free PSA

RESULTS: We identified two loci that were associated with %fPSA at a genome-wide significance level (P <5 ×10−8). The first associated SNP was rs3213764 (P = 6.45 × 10−10), a nonsynonymous variant (K530R) in the ATF7IP gene at 12p13. This variant was also nominally associated with tPSA (P = .015). The second locus was