کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2153678 1090200 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vivo comparison of DOTA based 68Ga-labelled bisphosphonates for bone imaging in non-tumour models
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
In vivo comparison of DOTA based 68Ga-labelled bisphosphonates for bone imaging in non-tumour models
چکیده انگلیسی

Bone metastases are a class of cancerous metastases that result from the invasion of a tumor into bone. The solid mass which forms inside the bone is often associated with a constant dull ache and severe spikes in pain, which greatly reduce the quality of life of the patient. Numerous 99mTc-labeled bisphosphonate functionalised complexes are well established tracers for bone metastases imaging. The objective of this research was to evaluate the pharmacokinetics and behaviour of three DOTA based bisphosphonate functionalised ligands (BPAMD, BPAPD and BPPED), using both 68Ga μ-PET in vivo imaging and ex vivo biodistribution studies in healthy Wistar rats. The compounds were labelled with 68Ga in high yields using an ammonium acetate buffer, and subsequently purified using a cation exchange resin. High bone uptake values were observed for all 68Ga-labelled bisphosphonates at 60 minutes p.i. The highest uptake was observed for [68Ga]BPPED (2.6 ± 0.3% ID/g) which compares favourably with that of [99mTc]MDP (2.7 ± 0.1 ID/g) and [18F]fluoride (2.4 ± 0.2% ID/g). The 68Ga-labelled DOTA-bisphosphonates showed rapid clearance from the blood and renal system, as well as low binding to soft tissue, resulting in a high bone to blood ratio (9.9 at 60 minutes p.i. for [68Ga]BPPED, for example). Although further studies are required to assess their performance in tumor models, the results obtained suggest that these ligands could be useful both in imaging (68Ga) and therapeutic treatment (177Lu) of bone metastases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 40, Issue 6, August 2013, Pages 823–830
نویسندگان
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