کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2154333 | 1090229 | 2011 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Site-specific 68Ga-labeled Annexin A5 as a PET imaging agent for apoptosis Site-specific 68Ga-labeled Annexin A5 as a PET imaging agent for apoptosis](/preview/png/2154333.png)
PurposeTwo variants of Annexin A5 (Cys2-AnxA5 and Cys165-AnxA5) were labelled with Gallium-68 in order to evaluate their biological properties.ProceduresBiodistribution and pharmacokinetics of the radiotracers were studied with μPET in healthy mice and in a mouse model of hepatic apoptosis. μPET imaging after IV injection of the tracers in combination with μMRI was performed in Daudi tumor bearing mice before and after treatment with a combination of chemotherapy and radiotherapy.ResultsThe biodistribution data indicated a fast urinary clearance with only minor hepatobilliary clearance, although a high retention in the kidneys was observed. Animals treated with anti-Fas showed a 3 to 8 times higher liver uptake as compared to healthy animals. Tumor uptake of 68Ga-Cys2-AnxA5 and 68Ga-Cys165-AnxA5 was low but significantly increased after therapy.ConclusionBoth 68Ga-Cys2-AnxA5 and 68Ga-Cys165-AnxA5 show a clear binding to apoptotic cells and are promising tracers for rapid evaluation of cancer therapy.
Journal: Nuclear Medicine and Biology - Volume 38, Issue 3, April 2011, Pages 381–392