کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2154627 | 1090244 | 2008 | 6 صفحه PDF | دانلود رایگان |
[18F]FDDNP is a positron emission tomography (PET) tracer for determining amyloid plaques and neurofibrillary tangles in the brain in vivo. In order to quantify binding of this tracer properly, a metabolite-corrected plasma input function is required. The purpose of the present study was to develop a sensitive method for measuring [18F]FDDNP and its radiolabelled metabolites in plasma. The second aim was to assess whether these radiolabelled metabolites enter the brain.In humans, there was extensive metabolism of [18F]FDDNP. After 10 min, more than 80% of plasma radioactivity was identified as polar 18F-labelled fragments, probably formed from N-dealkylation of [18F]FDDNP. These labelled metabolites were reproduced in vitro using human hepatocytes. PET studies in rats showed that these polar metabolites can penetrate the blood–brain barrier and result in uniform brain uptake.
Journal: Nuclear Medicine and Biology - Volume 35, Issue 8, November 2008, Pages 869–874