کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2154928 | 1090264 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro evaluation of no carrier added, carrier added and cross-complexed [90Y]-EDTMP provides evidence for a novel “foreign carrier theory”
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vitro evaluation of no carrier added, carrier added and cross-complexed [90Y]-EDTMP provides evidence for a novel “foreign carrier theory” In vitro evaluation of no carrier added, carrier added and cross-complexed [90Y]-EDTMP provides evidence for a novel “foreign carrier theory”](/preview/png/2154928.png)
چکیده انگلیسی
The present study focused on the preparation of novel bone tracers containing yttrium as radionuclide or carrier. Moreover, these preparations were comparatively evaluated in vitro on the basis of a recently presented pre vivo model comprising binding studies on synthetic and human bone powder. It was shown that among the therapeutic radionuclides, no carrier added [90Y]-EDTMP exceeded [188Re]-EDTMP while yielding lower binding values than [153Sm]-EDTMP. Furthermore, the authors investigated the influence of “foreign” carriers added to [90Y]-EDTMP, [99mTc]-EDTMP and [111In]-EDTMP by the method of cross-complexation. The findings reveal a new paradigm: a carrier more foreign to the complexed radionuclide causes a higher binding increase on human bone matrices in vitro than a more “related” carrier.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 33, Issue 1, January 2006, Pages 95-99
Journal: Nuclear Medicine and Biology - Volume 33, Issue 1, January 2006, Pages 95-99
نویسندگان
Stefan Toegel, Leonhard-Key Mien, Wolfgang Wadsak, Harald Eidherr, Helmut Viernstein, Rainer Kluger, Dagmar Ettlinger, Kurt Kletter, Robert Dudczak, Markus Mitterhauser,