کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2155387 1090394 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Colon cancer bears overexpression of OTUB1
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Colon cancer bears overexpression of OTUB1
چکیده انگلیسی

ObjectiveOTUB1 is a member of deubiquitinating enzymes; however, its expression and function in colon cancer are still unclear. The present study aimed at investigating the expression of OTUB1 in colon cancer and the relationship between the expression and some clinicopathologic parameters.MethodsImmunohistochemistry and quantitative real-time PCR were carried out in selected colon cancer and normal mucosa tissues.ResultsThe expression of OTUB1 protein in the colon cancer was significantly higher than normal mucosa, and the OTUB1 mRNA in colon cancer was also 3.15-fold higher than the normal mucosa. The higher expression of OTUB1 in colon cancer was related with tumor size, differentiation and lymph node metastasis.ConclusionsOTUB1 may play an important role in colon cancer development and metastasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 210, Issue 11, November 2014, Pages 770–773
نویسندگان
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