کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2155415 1090397 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of cancer stem cell markers in basal and penta-negative breast carcinomas – A study of a series of triple-negative tumors
ترجمه فارسی عنوان
بیان مارکرهای بنیادی سرطان در کارسینومهای پستان و پنتا منفی پستان مطالعه یک سری تومورهای سه گانه منفی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

PurposeBreast cancer is a heterogeneous disease. Immunohistochemistry has given rise to triple-negative carcinoma (TNC). Concomitantly, biological origins of neoplasia and its heterogeneity has been strongly debated in cancer stem cells (CSC) theme. This study investigates the prevalence of basal (BCC) and penta-negative carcinomas (5NC) in TNC and establishes associations with CSC (CD44CD24).Materials and methods94 TNC were tested for CK5/6, HER1, CD44 and CD24, evaluated by a simple immunohistochemistry score and correlated with clinicopathological and survival data.ResultsBCC had higher tumor grades than 5NC (p = 0.004). CD44 negativity (p = 0.007) and CD44−CD24+ phenotype (p = 0.013) were associated with less vascular invasion amongst TNC. CD44 expression was associated with BCC (p = 0.007). CD44−CD24−/low phenotype was associated with 5NC. None of the variables were associated with clinical outcome.ConclusionBCC and 5NC are closely related tumor subtypes. CD44−CD24−/low phenotype was associated with 5NC and CD44−CD24+ phenotype was associated with vascular invasion. These results require histogenetic confirmation in larger studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 210, Issue 7, July 2014, Pages 432–439
نویسندگان
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