کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2155854 | 1090426 | 2012 | 5 صفحه PDF | دانلود رایگان |

It is unclear if the extent of coronary atherosclerosis is associated with increase in heart muscle mass. We retrospectively reviewed autopsy reports of sudden coronary deaths occurring in a statewide medical examiner system over a one-year period. Cardiomegaly was assessed by height, and given a score of 0–4 based on amount above the upper limit of normal range. Coronary disease was quantitated as number of epicardial arteries with ≥75% cross sectional luminal narrowing. There were 100 hearts with one-vessel disease, 77 with two-vessel disease, and 59 with three- or four-vessel diseases. The extent of disease was less in women than men (P = 0.002). Healed infarcts were present in 21% of women and 36% of men. Cardiomegaly was present in 50% of women and 69% of men. By univariate analysis, in patients without hypertension, cardiomegaly score in the three- or four-vessel disease group was significantly greater than in the one-vessel disease group (P = 0.005), as well as the frequency of cardiomegaly (P = 0.001). Hearts with myocardial scar had a more frequent cardiomegaly (P = 0.0004) and higher cardiomegaly score (P = 0.004) than without myocardial scar. Moreover, by multivariate analysis, body mass index (P < 0.0001), extent of coronary disease (P = 0.02) and healed infarct (P = 0.04) were positively associated with cardiomegaly. We conclude that there is a significant correlation between the extent of coronary atherosclerosis and cardiac hypertrophy independent of age and body mass index in sudden coronary deaths as well as healed infarct. These data support a causative association between chronic ischemia and cardiomegaly
Journal: Pathology - Research and Practice - Volume 208, Issue 10, 15 October 2012, Pages 610–614