کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2156263 | 1090452 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The pattern of invasion of early carcinomas in Barrett's esophagus is dependent on the depth of infiltration The pattern of invasion of early carcinomas in Barrett's esophagus is dependent on the depth of infiltration](/preview/png/2156263.png)
The differential diagnosis “high-grade intraepithelial neoplasia” or “well-differentiated Barrett's adenocarcinoma limited to the mucosa” is controversial. We investigated 277 endoscopically resected specimens of early Barrett's carcinoma. Depth of infiltration was classified as follows: m 1=carcinoma limited to Barrett's mucosa; m 2=carcinoma infiltrating the neo-muscularis mucosae; m 3=infiltration of the original lamina propria of the esophageal mucosa; m 4=infiltration of the original muscularis mucosae; sm 1, sm 2, and sm 3=infiltration into the upper third, middle third, and lower third of the submucosa. The pattern of invasion was classified and graded as follows: tubular (D 0)=only neoplastic tubuli showing cytologic criteria of malignancy – no tumor cell dissociation; dissociation grade 1 (D 1)=few dissociated tumor cells; D 2=moderate amount of dissociated tumor cells; D 3=pronounced tumor cell dissociation. 74–96% of m 1–m 4 Barrett's carcinomas limited to the mucosa have a D 0-pattern. Tubular invasion decreases only when the submucosa has been infiltrated (sm 1: 70.4%, sm 2: 30.0%, sm 3: 24.0%). Our study shows that the pattern of invasion in early cancer in Barrett's esophagus statistically significantly depends on depth of infiltration.
Journal: Pathology - Research and Practice - Volume 206, Issue 5, 15 May 2010, Pages 300–304