کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2156378 1090459 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A distinct microvascular pattern accompanied by aggressive clinical course in breast carcinomas: A fact or a coincidence?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
A distinct microvascular pattern accompanied by aggressive clinical course in breast carcinomas: A fact or a coincidence?
چکیده انگلیسی

The aim of this study was to evaluate the potential relationship of microvascular growth patterns with survival in invasive breast carcinomas.Thirty-one invasive ductal carcinoma cases, followed up at least for 38 months, constituted our series. All cases had been studied for ER/PR and HER2/neu expression. Clinicopathological and survival data were obtained from the archives. Tissue sections from all cases were stained with CD34 antibody to highlight the microvascular network and to measure microvessel density (MVD). The cases were then classified according to the dominance of one of the five recognizable microvascular patterns. Cox proportional hazard regression model, Fisher's exact test, and multivariate general linear model (GLM) were used to uncover the effects of the variables, such as nodal status, distant metastasis, angiogenic patterns, and MVD, on survival.There was an association between only one of the microvascular patterns and aggressive clinical course. Increased blood-filled capillaries with some clustering in the tumor might be a predictor of aggressive biological behavior in invasive breast carcinomas. Similar studies investigating larger series are needed before a generalized conclusion can be made.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 206, Issue 2, 15 February 2010, Pages 93–97
نویسندگان
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