کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2156441 1090463 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fibrillary glomerulonephritis mimicking membranous nephropathy – A diagnostic pitfall
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Fibrillary glomerulonephritis mimicking membranous nephropathy – A diagnostic pitfall
چکیده انگلیسی

Kidney biopsies in 2 females with nephrotic syndrome were suggestive of membranous nephropathy at routine light microscopy and immunohistochemistry. Electron microscopy on re-embedded paraffin tissue, however, revealed that the light microscopic pattern was due to a fibrillary glomerulonephritis with a dominant membranous manifestation.These findings suggest that (a) fibrillary glomerulonephritis may be mis-/under-diagnosed at light microscopy; and (b) in reality, a subset of therapy refractory membranous nephropathies might represent fibrillary glomerulopathies.Therefore, electron microscopy is mandatory in any case of membranous nephropathy with therapy refractory nephrotic syndrome or an unusual immunohistological staining pattern, e.g. with mesangial immunoreactivity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 205, Issue 4, 15 April 2009, Pages 265–271
نویسندگان
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