کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2157195 | 1090768 | 2016 | 5 صفحه PDF | دانلود رایگان |

Background and purposeWe hypothesize that the lesion-to-lesion variability in FDG-PET response after one cycle of chemotherapy for NSCLC in an individual patient may inform radiation dose redistribution. To test this hypothesis, we investigate if time to lesion-progression in patients with multiple lesions is dependent on lesion-specific response to chemotherapy.Materials and methodsWe analyzed 81 patients with 184 lesions referred to curative chemo-radiotherapy for NSCLC 2010–2012. 18F-FDG PET scans were performed at diagnosis and after one series of chemotherapy. Response of each lesion was assessed as the change in FDG peak standardized uptake value. Variance of lesion response was compared within and between patients. Time to progression for each lesion was analyzed using the Kaplan–Meier method and the Cox proportional hazards model.ResultsWithin-patient variability in lesion responses was of the same magnitude as the between-patient variability. Lesion-specific time to progression was longer in lesions with a better response (log-rank p = 0.038). Nodal lesions had a much lower risk of progression than T-site lesions (HR = 0.09, p < 0.0001).ConclusionsRecording an overall patient response involves a loss of biological information on heterogeneity between lesions. Poor lesion-specific response after one cycle chemotherapy may identify lesions that would benefit from an individualized radiotherapy strategy.
Journal: Radiotherapy and Oncology - Volume 118, Issue 3, March 2016, Pages 460–464