کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2157886 | 1090816 | 2012 | 6 صفحه PDF | دانلود رایگان |

PurposeTo compare three-dimensional conformal radiotherapy (3D-CRT) with intensity modulated radiation therapy (IMRT) in curative-intent irradiation of head-neck squamous cell carcinoma (HNSCC).MethodsPreviously untreated patients with biopsy-proven squamous carcinoma of oropharynx, larynx, or hypopharynx (T1-3, N0-2b) were randomly assigned using computer-generated permuted-block design to either 3D-CRT or IMRT, with incidence of physician-rated Radiation Therapy Oncology Group (RTOG) grade 2 or worse acute salivary gland toxicity as primary end-point.ResultsBetween 2005 and 2008, 60 patients randomly allocated to either 3D-CRT (n = 28 patients) or IMRT (n = 32) were included and analyzed on an intention-to-treat basis. The proportion [95% confidence intervals (CI)] of patients with RTOG grade 2 or worse acute salivary gland toxicity was significantly lesser in the IMRT arm [19 of 32 patients (59%, 95% CI: 42–75%)] as compared to 3D-CRT [25 of 28 patients (89%, 95% CI: 72–97%; p = 0.009)]. Late xerostomia and subcutaneous fibrosis were also significantly lesser with IMRT. There was significant recovery of salivary function over time in patients treated with IMRT (p-value for trend = 0.0036). At 3-years, there were no significant differences in loco-regional control or survival between the two arms.ConclusionIMRT significantly reduces the incidence and severity of xerostomia compared to 3D-CRT in curative-intent irradiation of HNSCC.
Journal: Radiotherapy and Oncology - Volume 104, Issue 3, September 2012, Pages 343–348