کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2158597 1090836 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Locoregional and distant failure following image-guided stereotactic body radiation for early-stage primary lung cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Locoregional and distant failure following image-guided stereotactic body radiation for early-stage primary lung cancer
چکیده انگلیسی

PurposeTo report our institutional experience using image-guided stereotactic body radiation therapy (SBRT) for early stage lung cancer, including an analysis into factors associated with nodal and distant failures (NF, DF).MethodsForty-eight patients with early-stage primary lung cancer were treated with image-guided SBRT between 2007 and 2009. Median prescription dose was 48 Gy in 4 fractions. Toxicity was graded according to the NCI CTCAE v3.0 scale.ResultsLocal failure was detected in two lesions and actuarial 24-month local control was 95%. At 24 months, the cumulative incidence of NF was 6%, and DF was 29%. Larger lesions (>3 cm) and younger age (<70 years) were the only factors found to be significantly correlated with increased DF (p = 0.005 and p = 0.015, respectively). A single grade ⩾3 toxicity was observed. After adjusting for age and lesion size, distant failure was significantly associated with a poorer OS (Cox regression, p = 0.0059).ConclusionImage-guided SBRT can produce excellent LC rates with minimal toxicity. Distant failure was a major determinant of OS and the most common pattern of failure, indicating a potential role for systemic therapy in younger patients with large lesions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 99, Issue 1, April 2011, Pages 12–17
نویسندگان
, , , , , , , , , ,