کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2159280 | 1090854 | 2009 | 6 صفحه PDF | دانلود رایگان |

Background and purposeThe aim of this study was to compare the need for re-irradiation, rates of pathological fractures, and spinal cord compressions in patients randomised to single-fraction radiotherapy (8 Gy × 1) or multiple-fraction therapy (3 Gy × 10) and with a long-term follow-up. The underlying hypothesis was that single-fraction and multiple-fraction regimens are equally effective.Material and methodsThe present study reports on the Norwegian sub sample of an international large prospective-randomised multicentre study. One hundred and eighty patients with painful skeletal metastases in four Norwegian hospitals were randomised to receive single-fraction (8 Gy × 1) or multiple-fraction (3 Gy × 10) radiotherapy.ResultsPatients in the single-fraction arm received significantly more re-irradiations as compared to the multiple-fraction arm (27% versus 9%, p = 0.002). There were no significant differences in the rate of pathological fractures (5% versus 5%, p = 1.00) or spinal cord compressions (1% versus 4%, p = 0.37) between the two treatment groups.ConclusionThe present study indicates no difference between radiotherapy with 8 Gy × 1 and 3 Gy × 10 for the majority of patients with painful bone metastases, also in a long-term perspective. Importantly, the patients in this study were followed up until death, and the trial showed no disadvantage for 8 Gy × 1 compared to 3 Gy × 10. Despite the fact that single-fraction treatment will imply an approximately 2.5-fold greater need for re-irradiation, single-fraction treatment is considered more convenient for the patients and more cost-effective for the radiotherapy departments.
Journal: Radiotherapy and Oncology - Volume 91, Issue 2, May 2009, Pages 261–266