IMRT-based optimization approaches for volumetric modulated single arc radiotherapy planning

This paper reports on an evaluation of 5 RapidArc® optimization approaches vs IMRT. This study includes 11 patients with adenocarcinoma of the prostate. Rectal Normal Tissue Complication Probability is used as a constraint in a dose escalation. RapidArc® rectal NTCP’s are lower than those of IMRT (p = 0.007). This allows a mean dose escalation of 2.1 Gy([0.7 Gy,3.5 Gy]).