کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2159728 1090865 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GTV spatial conformity between different delineation methods by 18FDG PET/CT and pathology in esophageal cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
GTV spatial conformity between different delineation methods by 18FDG PET/CT and pathology in esophageal cancer
چکیده انگلیسی

PurposeTo find optimal threshold of length and GTV delineation for esophageal cancer using 18FDG PET/CT.Materials and methodsSixteen patients with esophageal carcinoma underwent surgery. For each patient, six GTVs were defined. GTVCT was based on CT data alone. GTV20%, GTV40%, GTV2.5 and GTV40%M were generated by PET/CT, using SUVbgd + 20%(SUVmax(slice) − SUVbgd), SUVbgd + 40%(SUVmax(slice) − SUVbgd), 2.5 and 40%SUVmax(total) as thresholds. GTVpath was derived from pathology. Lengths of GTVs were recorded as LCT, L20%, L40%, L2.5,L40%M and Lpath, respectively. The former five GTVs/lengths were compared with GTVpath/Lpath by means of a conformity index CI/CI′, which is the square of intersection of two GTVs/lengths divided by their product.ResultsMean LCT, L20%, L40%, L2.5, L40%M and Lpath were 6.30 ± 2.69, 5.55 ± 2.48, 6.80 ± 2.92, 6.65 ± 2.66, 4.88 ± 1.99 and 5.90 ± 2.38 cm. Mean CICT&path′, CI20%&path′, CI40%&path′, CI2.5&path′ and CI40%M&path′ were 0.68 ± 0.16, 0.84 ± 0.17, 0.76 ± 0.14, 0.78 ± 0.15 and 0.80 ± 0.11. CI20%&path′ and CI40%M&path′ was significantly superior to CICT&path′ (P < 0.05). Mean GTVCT, GTV20%, GTV40%, GTV2.5, GTV40%M and GTVpath were 29.16 ± 18.56, 18.75 ± 12.37, 12.52 ± 8.08, 22.69 ± 14.84, 9.18 ± 5.96 and 28.16 ± 17.02 cm3. Mean CIs increased significantly from CI40%&path(0.27 ± 0.09) and CI40%M&path(0.28 ± 0.08) < CI20%&path(0.52 ± 0.16) and CI2.5&path(0.52 ± 0.20) < CICT&path(0.77 ± 0.17).ConclusionsThe SUVbgd + 20%(SUVmax(slice) − SUVbgd) method optimally estimated gross tumor length, but only reached an unsatisfactory CI for GTV. Due to possible motion factor enveloped in PET images and lack of histopathologic transverse reference, the information from both PET and CT should be referred to complementarily when delineating GTV.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 93, Issue 3, December 2009, Pages 441–446
نویسندگان
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