کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2159729 1090865 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Consequences of additional use of PET information for target volume delineation and radiotherapy dose distribution for esophageal cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Consequences of additional use of PET information for target volume delineation and radiotherapy dose distribution for esophageal cancer
چکیده انگلیسی

Background and purposeTo determine the consequences of target volume (TV) modifications, based on the additional use of PET information, on radiation planning, assuming PET/CT-imaging represents the true extent of the tumour.Materials and methodsFor 21 patients with esophageal cancer, two separate TV’s were retrospectively defined based on CT (CT-TV) and co-registered PET/CT images (PET/CT-TV). Two 3D-CRT plans (prescribed dose 50.4 Gy) were constructed to cover the corresponding TV’s. Subsequently, these plans were compared for target coverage, normal tissue dose–volume histograms and the corresponding normal tissue complication probability (NTCP) values.ResultsThe addition of PET led to the modification of CT-TV with at least 10% in 12 of 21 patients (57%) (reduction in 9, enlargement in 3). PET/CT-TV was inadequately covered by the CT-based treatment plan in 8 patients (36%). Treatment plan modifications resulted in significant changes (p < 0.05) in dose distributions to heart and lungs. Corresponding changes in NTCP values ranged from −3% to +2% for radiation pneumonitis and from −0.2% to +1.2% for cardiac mortality.ConclusionsThis study demonstrated that TV’s based on CT might exclude PET-avid disease. Consequences are under dosing and thereby possibly ineffective treatment. Moreover, the addition of PET in radiation planning might result in clinical important changes in NTCP.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 93, Issue 3, December 2009, Pages 447–453
نویسندگان
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